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Fred R. Hirsch

Fred R. Hirsch

D-Index & Metrics

Medicine

D-Index
124
Citations
72393
World Ranking
3171
National Ranking
132

Overview

Fred R. Hirsch is affiliated with Mount Sinai Hospital in Canada and has conducted extensive research in medicine, with a primary focus on oncology and pulmonary and respiratory medicine. Their work also spans molecular biology, infectious diseases, and epidemiology, reflecting a broad interdisciplinary approach within medical science.

Their research topics prominently include lung cancer research studies, lung cancer treatments and mutations, peptidase inhibition and analysis, neuroendocrine tumor research advances, ferroptosis and cancer prognosis, thyroid cancer diagnosis and treatment, and cancer immunotherapy and biomarkers.

Notable recent publications by Fred R. Hirsch include:

  • Comprehensive Immune Profiling of Medullary Thyroid Cancer, 2020, Thyroid
  • Small cells - big issues: biological implications and preclinical advancements in small cell lung cancer, 2024, Molecular Cancer
  • RAC1 inhibition ameliorates IBSP-induced bone metastasis in lung adenocarcinoma, 2024, Cell Reports
  • Reply to Waller et al. Standardizing Surgical Treatment for Mesothelioma, 2020, Journal of Thoracic Oncology
  • Analysis of Orthologous Gene Expression between Human Pulmonary Adenocarcinoma and a Carcinogen-Induced Murine Model, 2020, UNC Libraries

Fred R. Hirsch has collaborated frequently with a number of coauthors, including Christopher J. Rivard, Zoltán Lohinai, Anna Solta, Büsra Ernhofer, and Kristiina Boettiger. The collaborative efforts with these researchers highlight a network engaged in advancing studies primarily related to oncology and respiratory medicine.

Their work has been published across several prominent venues, with repeated contributions to the Journal of Thoracic Oncology. Other publication sites include Molecular Cancer, Thyroid, Cell Reports, and UNC Libraries, indicating a presence in both specialized cancer journals and broader academic repositories.

Best Publications

  • International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma

    William D Travis;Elisabeth Brambilla;Masayuki Noguchi;Andrew G Nicholson

  • The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification

    William D. Travis;Elisabeth Brambilla;Andrew G. Nicholson;Yasushi Yatabe

  • Lung cancer: current therapies and new targeted treatments

    Fred R Hirsch;Giorgio V Scagliotti;James L Mulshine;Regina Kwon

  • Epidermal Growth Factor Receptor Gene and Protein and Gefitinib Sensitivity in Non–Small-Cell Lung Cancer

    Federico Cappuzzo;Fred R. Hirsch;Elisa Rossi;Stefania Bartolini

  • Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis.

    Fred R. Hirsch;Marileila Varella-Garcia;Paul A. Bunn;Michael V. Di Maria

  • Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors: Guideline From the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology

    Neal I. Lindeman;Philip T. Cagle;Dara L. Aisner;Maria E. Arcila

  • PD-L1 as a biomarker of response to immune-checkpoint inhibitors

    Deborah Blythe Doroshow;Sheena Bhalla;Mary Beth Beasley;Lynette M. Sholl

  • PD-L1 Immunohistochemistry Assays for Lung Cancer: Results from Phase 1 of the Blueprint PD-L1 IHC Assay Comparison Project

    Fred R. Hirsch;Abigail McElhinny;Dave Stanforth;James Ranger-Moore

  • Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer

    Fred R. Hirsch;Marileila Varella-Garcia;Paul A. Bunn;Wilbur A. Franklin

  • Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group Part 2 TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non–Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors

    Shona Hendry;Roberto Salgado;Thomas Gevaert;Prudence A. Russell;Prudence A. Russell

  • Increased Epidermal Growth Factor Receptor Gene Copy Number Detected by Fluorescence In Situ Hybridization Associates With Increased Sensitivity to Gefitinib in Patients With Bronchioloalveolar Carcinoma Subtypes: A Southwest Oncology Group Study

    Fred R. Hirsch;Marileila Varella-Garcia;Jason McCoy;Howard West

  • Tumor Mutational Burden and Efficacy of Nivolumab Monotherapy and in Combination with Ipilimumab in Small-Cell Lung Cancer.

    Matthew D. Hellmann;Margaret K. Callahan;Mark M. Awad;Emiliano Calvo

  • Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma in Situ, Metastatic Tumor Deposits and Areas for Further Research

    Shona Hendry;Roberto Salgado;Thomas Gevaert;Prudence A. Russell;Prudence A. Russell

  • Early Detection of Lung Cancer: Clinical Perspectives of Recent Advances in Biology and Radiology

    Fred R. Hirsch;Wilbur A. Franklin;Adi F. Gazdar;Paul A. Bunn

  • A prospective, multi-institutional, pathologist-based assessment of 4 immunohistochemistry assays for PD-L1 expression in non–small cell lung cancer

    David L. Rimm;Gang Han;Janis M. Taube;Eunhee S. Yi

  • Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas.

    Christine H. Chung;Kim Ely;Loris McGavran;Marileila Varella-Garcia

  • International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society: international multidisciplinary classification of lung adenocarcinoma: executive summary.

    William D. Travis;Elisabeth Brambilla;Masayuki Noguchi;Andrew G. Nicholson

  • PD-L1 Immunohistochemistry Comparability Study in Real-Life Clinical Samples: Results of Blueprint Phase 2 Project.

    Ming Sound Tsao;Keith M. Kerr;Mark Kockx;Mary Beth Beasley

  • Liquid Biopsy for Advanced Non-Small Cell Lung Cancer (NSCLC): A Statement Paper from the IASLC

    Christian Rolfo;Philip C. Mack;Giorgio V. Scagliotti;Paul Baas

  • Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines.

    Samir E. Witta;Robert M. Gemmill;Fred R. Hirsch;Christopher D. Coldren

Frequent Co-Authors

Paul A. Bunn
Paul A. Bunn University of Colorado Boulder
David R. Gandara
David R. Gandara University of California, Davis
Caicun Zhou
Caicun Zhou Tongji University
Wilbur A. Franklin
Wilbur A. Franklin University of Colorado Denver
Keith M. Kerr
Keith M. Kerr Aberdeen Royal Infirmary
Roy S. Herbst
Roy S. Herbst Yale University
Suresh S. Ramalingam
Suresh S. Ramalingam Emory University
Ming-Sound Tsao
Ming-Sound Tsao Princess Margaret Cancer Centre
Ignacio I. Wistuba
Ignacio I. Wistuba The University of Texas MD Anderson Cancer Center
Yasushi Yatabe
Yasushi Yatabe Nagoya University

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