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Michael O. Hottiger

Michael O. Hottiger

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Biology and Biochemistry
Switzerland
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
81
Citations
25459
World Ranking
3861
National Ranking
76

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Switzerland Leader Award

Overview

Michael O. Hottiger is affiliated with the University of Zurich in Switzerland and conducts research primarily in the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their work includes significant contributions in several subfields such as Molecular Biology, Oncology, Physiology, Immunology, and Geriatrics and Gerontology.

The scientist's research focuses on key topics including PARP inhibition in cancer therapy, calcium signaling and nucleotide metabolism, toxin mechanisms and immunotoxins, DNA repair mechanisms, RNA and protein synthesis mechanisms, cell death mechanisms and regulation, and CRISPR and genetic engineering.

Among recent publications are:

  • ADP-ribosyltransferases, an update on function and nomenclature (2021, FEBS Journal)
  • Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins (2020, Nature Communications)
  • A Type I-F Anti-CRISPR Protein Inhibits the CRISPR-Cas Surveillance Complex by ADP-Ribosylation (2020, Molecular Cell)
  • Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation (2021, Molecular Cell)
  • Genetic evidence for partial redundancy between the arginine methyltransferases CARM1 and PRMT6 (2020, Journal of Biological Chemistry)

Michael O. Hottiger collaborates frequently with several researchers, including Deena M. Leslie Pedrioli, Ann-Katrin Hopp, Kathrin Nowak, Patrick Manetsch, and Lukas Muskalla. These coauthors have contributed to multiple joint publications, underscoring sustained collaborative research efforts.

Research outputs are often published in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Molecular Cell, Cells, and Methods in Molecular Biology. These journals reflect a consistent presence in both preprint and peer-reviewed scientific communication.

Best Publications

  • Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

    Raul Mostoslavsky;Katrin F. Chua;Katrin F. Chua;David B. Lombard;Wendy W. Pang

  • Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?

    Paul O. Hassa;Sandra S. Haenni;Michael Elser;Michael O. Hottiger

  • Toward a unified nomenclature for mammalian ADP-ribosyltransferases

    Michael O. Hottiger;Paul O. Hassa;Bernhard Lüscher;Herwig Schüler

  • p53 inhibition by the LANA protein of KSHV protects against cell death.

    Jacques Friborg;Wing-pui Kong;Michael O. Hottiger;Michael O. Hottiger;Gary J. Nabel

  • The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases.

    Paul O Hassa;Michael O Hottiger

  • Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation.

    Bin Ma;Michael O. Hottiger

  • A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation.

    Gyula Timinszky;Susanne Till;Paul O Hassa;Michael Hothorn

  • Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites

    Matthias Altmeyer;Simon Messner;Paul O. Hassa;Monika Fey

  • Poly(ADP-Ribose) Polymerase 1 Participates in the Phase Entrainment of Circadian Clocks to Feeding

    Gad Asher;Hans Reinke;Matthias Altmeyer;Maria Gutierrez-Arcelus

  • Proteome-wide Identification of Poly(ADP-Ribosyl)ation Targets in Different Genotoxic Stress Responses

    Stephanie Jungmichel;Florian Rosenthal;Matthias Altmeyer;Jiri Lukas

  • Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation.

    Henning Kleine;Elzbieta Poreba;Krzysztof Lesniewicz;Paul O. Hassa

  • SIRT2 regulates NF-κB-dependent gene expression through deacetylation of p65 Lys310

    Karin M. Rothgiesser;Süheda Erener;Susanne Waibel;Bernhard Lüscher

  • A role of poly (ADP-ribose) polymerase in NF-kappaB transcriptional activation.

    Paul O. Hassa;Michael O. Hottiger

  • The Enzymatic and DNA Binding Activity of PARP-1 Are Not Required for NF-κB Coactivator Function

    Paul O. Hassa;Marcela Covic;Sameez Hasan;Ralph Imhof

  • Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells.

    Isabella M. Toller;Kai J. Neelsen;Martin Steger;Mara L. Hartung

  • Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases.

    Florian Rosenthal;Karla L H Feijs;Emilie Frugier;Mario Bonalli

  • Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription

    Paul O. Hassa;Sandra S. Haenni;Christine Buerki;Nadja I. Meier

  • SIRT1 Promotes Cell Survival under Stress by Deacetylation-Dependent Deactivation of Poly(ADP-Ribose) Polymerase 1

    Senthilkumar B. Rajamohan;Vinodkumar B. Pillai;Madhu Gupta;Nagalingam R. Sundaresan

  • PARP1 ADP-ribosylates lysine residues of the core histone tails

    Simon Messner;Matthias Altmeyer;Hongtao Zhao;Andrea Pozivil

  • PARP-1 and gene regulation: Progress and puzzles

    W. Lee Kraus;Michael O. Hottiger

Frequent Co-Authors

Ulrich Hübscher
Ulrich Hübscher University of Zurich
Matthias Altmeyer
Matthias Altmeyer University of Zurich
Igor Stagljar
Igor Stagljar University of Toronto
Gary J. Nabel
Gary J. Nabel ModeX Therapeutics
Thomas F. Lüscher
Thomas F. Lüscher University of Zurich
Bernhard Lüscher
Bernhard Lüscher RWTH Aachen University
Johan Auwerx
Johan Auwerx École Polytechnique Fédérale de Lausanne
Burkhard Becher
Burkhard Becher University of Zurich
Alke Petri-Fink
Alke Petri-Fink University of Fribourg
Heinrich Hofmann
Heinrich Hofmann École Polytechnique Fédérale de Lausanne

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