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Michael O. Hottiger

Michael O. Hottiger

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Biology and Biochemistry
Switzerland
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
81
Citations
25459
World Ranking
3861
National Ranking
76

Michael O. Hottiger publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Michael O. Hottiger sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 214 publications — 55th percentile

55% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Michael O. Hottiger D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Michael O. Hottiger sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 81 D-Index — 81st percentile

81% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Switzerland Leader Award

Overview

Michael O. Hottiger is affiliated with the University of Zurich in Switzerland and conducts research primarily in the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their work includes significant contributions in several subfields such as Molecular Biology, Oncology, Physiology, Immunology, and Geriatrics and Gerontology.

The scientist's research focuses on key topics including PARP inhibition in cancer therapy, calcium signaling and nucleotide metabolism, toxin mechanisms and immunotoxins, DNA repair mechanisms, RNA and protein synthesis mechanisms, cell death mechanisms and regulation, and CRISPR and genetic engineering.

Among recent publications are:

  • ADP-ribosyltransferases, an update on function and nomenclature (2021, FEBS Journal)
  • Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins (2020, Nature Communications)
  • A Type I-F Anti-CRISPR Protein Inhibits the CRISPR-Cas Surveillance Complex by ADP-Ribosylation (2020, Molecular Cell)
  • Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation (2021, Molecular Cell)
  • Genetic evidence for partial redundancy between the arginine methyltransferases CARM1 and PRMT6 (2020, Journal of Biological Chemistry)

Michael O. Hottiger collaborates frequently with several researchers, including Deena M. Leslie Pedrioli, Ann-Katrin Hopp, Kathrin Nowak, Patrick Manetsch, and Lukas Muskalla. These coauthors have contributed to multiple joint publications, underscoring sustained collaborative research efforts.

Research outputs are often published in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Molecular Cell, Cells, and Methods in Molecular Biology. These journals reflect a consistent presence in both preprint and peer-reviewed scientific communication.

Best Publications

  • Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

    Raul Mostoslavsky;Katrin F. Chua;Katrin F. Chua;David B. Lombard;Wendy W. Pang

  • Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?

    Paul O. Hassa;Sandra S. Haenni;Michael Elser;Michael O. Hottiger

  • Toward a unified nomenclature for mammalian ADP-ribosyltransferases

    Michael O. Hottiger;Paul O. Hassa;Bernhard Lüscher;Herwig Schüler

  • p53 inhibition by the LANA protein of KSHV protects against cell death.

    Jacques Friborg;Wing-pui Kong;Michael O. Hottiger;Michael O. Hottiger;Gary J. Nabel

  • The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases.

    Paul O Hassa;Michael O Hottiger

  • Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation.

    Bin Ma;Michael O. Hottiger

  • A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation.

    Gyula Timinszky;Susanne Till;Paul O Hassa;Michael Hothorn

  • Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites

    Matthias Altmeyer;Simon Messner;Paul O. Hassa;Monika Fey

  • Poly(ADP-Ribose) Polymerase 1 Participates in the Phase Entrainment of Circadian Clocks to Feeding

    Gad Asher;Hans Reinke;Matthias Altmeyer;Maria Gutierrez-Arcelus

  • Proteome-wide Identification of Poly(ADP-Ribosyl)ation Targets in Different Genotoxic Stress Responses

    Stephanie Jungmichel;Florian Rosenthal;Matthias Altmeyer;Jiri Lukas

  • Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation.

    Henning Kleine;Elzbieta Poreba;Krzysztof Lesniewicz;Paul O. Hassa

  • SIRT2 regulates NF-κB-dependent gene expression through deacetylation of p65 Lys310

    Karin M. Rothgiesser;Süheda Erener;Susanne Waibel;Bernhard Lüscher

  • A role of poly (ADP-ribose) polymerase in NF-kappaB transcriptional activation.

    Paul O. Hassa;Michael O. Hottiger

  • The Enzymatic and DNA Binding Activity of PARP-1 Are Not Required for NF-κB Coactivator Function

    Paul O. Hassa;Marcela Covic;Sameez Hasan;Ralph Imhof

  • Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells.

    Isabella M. Toller;Kai J. Neelsen;Martin Steger;Mara L. Hartung

  • Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases.

    Florian Rosenthal;Karla L H Feijs;Emilie Frugier;Mario Bonalli

  • Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription

    Paul O. Hassa;Sandra S. Haenni;Christine Buerki;Nadja I. Meier

  • SIRT1 Promotes Cell Survival under Stress by Deacetylation-Dependent Deactivation of Poly(ADP-Ribose) Polymerase 1

    Senthilkumar B. Rajamohan;Vinodkumar B. Pillai;Madhu Gupta;Nagalingam R. Sundaresan

  • PARP1 ADP-ribosylates lysine residues of the core histone tails

    Simon Messner;Matthias Altmeyer;Hongtao Zhao;Andrea Pozivil

  • PARP-1 and gene regulation: Progress and puzzles

    W. Lee Kraus;Michael O. Hottiger

Frequent Co-Authors

Ulrich Hübscher
Ulrich Hübscher University of Zurich
Matthias Altmeyer
Matthias Altmeyer University of Zurich
Igor Stagljar
Igor Stagljar University of Toronto
Gary J. Nabel
Gary J. Nabel ModeX Therapeutics
Thomas F. Lüscher
Thomas F. Lüscher University of Zurich
Bernhard Lüscher
Bernhard Lüscher RWTH Aachen University
Johan Auwerx
Johan Auwerx École Polytechnique Fédérale de Lausanne
Burkhard Becher
Burkhard Becher University of Zurich
Alke Petri-Fink
Alke Petri-Fink University of Fribourg
Heinrich Hofmann
Heinrich Hofmann École Polytechnique Fédérale de Lausanne

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