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D-Index & Metrics

Biology and Biochemistry

D-Index
100
Citations
33557
World Ranking
1535
National Ranking
864

Research.com Recognitions

  • 1992 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

David R. Eyre is affiliated with the University of Washington in the United States. Their research spans multiple fields within biochemistry, genetics, molecular biology, and medicine. A significant focus of their work lies in connective tissue disorders, bone and dental protein studies, and protease and inhibitor mechanisms, alongside specific interests in TGF-β signaling, macrophage migration inhibitory factor, tendon structure and treatment, and vitamin K research.

Their prominent research output includes publications primarily in journals such as Matrix Biology, bioRxiv (Cold Spring Harbor Laboratory), JBMR Plus, Matrix Biology Plus, and The Journal of the American Dental Association. These venues have featured several of their papers, reflecting an emphasis on molecular and structural aspects of connective tissue and bone biology.

Recent key papers authored or co-authored by Eyre include:

  • "Crtap and p3h1 knock out zebrafish support defective collagen chaperoning as the cause of their osteogenesis imperfecta phenotype" (2020, Matrix Biology)
  • "Abnormal Bone Collagen Cross-Linking in Osteogenesis Imperfecta/Bruck Syndrome Caused by Compound Heterozygous PLOD2 Mutations" (2020, JBMR Plus)
  • "Age-related type I collagen modifications reveal tissue-defining differences between ligament and tendon" (2021, Matrix Biology Plus)
  • "Malocclusion traits and oral health-related quality of life in children with osteogenesis imperfecta" (2020, The Journal of the American Dental Association)
  • "Substitution of murine type I collagen A1 3-hydroxylation site alters matrix structure but does not recapitulate osteogenesis imperfecta bone dysplasia" (2020, Matrix Biology)

Frequent collaborators include Brendan Lee, MaryAnn Weis, V. Reid Sutton, Deborah Krakow, and Jyoti Rai. These collaborators have contributed to multiple projects and publications alongside Eyre, indicating a strong network within the field of connective tissue biology and related medical research.

Eyre's main fields of study are:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Their research also intersects several subfields, such as:

  • Genetics
  • Molecular Biology
  • Rheumatology
  • Cancer Research
  • Orthopedics and Sports Medicine

Core research topics include:

  • Connective tissue disorders research
  • Bone and Dental Protein Studies
  • Protease and Inhibitor Mechanisms
  • TGF-β signaling in diseases
  • Macrophage Migration Inhibitory Factor
  • Tendon Structure and Treatment
  • Vitamin K Research Studies

David R. Eyre was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 1992, a distinction reflecting their standing within the scientific community.

Best Publications

  • CROSS-LINKING IN COLLAGEN AND ELASTIN

    David R. Eyre;Mercedes A. Paz;Paul M. Gallop

  • Quantitation of hydroxypyridinium crosslinks in collagen by high-performance liquid chromatography.

    David R. Eyre;Thomas J. Koob;Kirk P. Van Ness

  • A specific immunoassay for monitoring human bone resorption: quantitation of type I collagen cross-linked N-telopeptides in urine

    Dennis A. Hanson;Mary Ann E Weis;Anne Marie Bollen;Shoshana L. Maslan

  • Articular cartilage and changes in Arthritis: Collagen of articular cartilage

    David Eyre

  • Biochemical studies on repair cartilage resurfacing experimental defects in the rabbit knee.

    T Furukawa;D R Eyre;S Koide;M J Glimcher

  • Collagen: molecular diversity in the body's protein scaffold.

    David R. Eyre

  • Collagen cross-linking in human bone and articular cartilage. Age-related changes in the content of mature hydroxypyridinium residues.

    D R Eyre;I R Dickson;K Van Ness

  • CRTAP is required for prolyl 3- hydroxylation and mutations cause recessive osteogenesis imperfecta.

    Roy Morello;Terry K. Bertin;Yuqing Chen;Yuqing Chen;John Hicks

  • Prolyl 3-hydroxylase 1 deficiency causes a recessive metabolic bone disorder resembling lethal/severe osteogenesis imperfecta

    Wayne A Cabral;Weizhong Chang;Aileen M Barnes;MaryAnn Weis

  • Viscoelastic shear properties of articular cartilage and the effects of glycosidase treatments.

    Wenbo Zhu;Van C. Mow;Thomas J. Koob;David R. Eyre

  • Effects of proteoglycan extraction on the tensile behavior of articular cartilage

    Mary Beth Schmidt;Van C. Mow;Lawrence E. Chun;David R. Eyre

  • Deficiency of Cartilage-Associated Protein in Recessive Lethal Osteogenesis Imperfecta

    Aileen M. Barnes;Weizhong Chang;Roy Morello;Wayne A. Cabral

  • Quantitative analysis of types I and II collagens in human intervertebral discs at various ages

    David R. Eyre;Helen Muir

  • Collagen type IX: evidence for covalent linkages to type II collagen in cartilage.

    David R. Eyre;Stephen Apon;Jiann Jiu Wu;Lowell H. Ericsson

  • Homozygosity for a Missense Mutation in SERPINH1, which Encodes the Collagen Chaperone Protein HSP47, Results in Severe Recessive Osteogenesis Imperfecta

    Helena E. Christiansen;Ulrike Schwarze;Shawna M. Pyott;Abdulrahman AlSwaid

  • Soft-tissue aging and musculoskeletal function.

    J. A. Buckwalter;S. L Y Woo;V. M. Goldberg;E. C. Hadley

  • Sublingual testosterone replacement improves muscle mass and strength, decreases bone resorption, and increases bone formation markers in hypogonadal men - A clinical research center study

    C Wang;D R Eyre;R Clark;D Kleinberg

  • Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage.

    Jiann-Jiu Wu;M. W. Lark;L. E. Chun;D. R. Eyre

  • Mutations in the Gene Encoding the RER Protein FKBP65 Cause Autosomal-Recessive Osteogenesis Imperfecta

    Yasemin Alanay;Hrispima Avaygan;Natalia Camacho;G. Eda Utine

  • Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis

    V. B. Kraus;B. Burnett;J. Coindreau;S. Cottrell

Frequent Co-Authors

MaryAnn Weis
MaryAnn Weis University of Washington
Daniel H. Cohn
Daniel H. Cohn University of California, Los Angeles
Joan C. Marini
Joan C. Marini National Institutes of Health
Brendan Lee
Brendan Lee Baylor College of Medicine
Sergey Leikin
Sergey Leikin National Institutes of Health
David L. Rimoin
David L. Rimoin Cedars-Sinai Medical Center
Deborah Krakow
Deborah Krakow University of California, Los Angeles
Peter H. Byers
Peter H. Byers University of Washington
Melvin J. Glimcher
Melvin J. Glimcher Harvard University
William R. Wilcox
William R. Wilcox Emory University

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