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Chemistry

D-Index
77
Citations
20660
World Ranking
4035
National Ranking
1279

Research.com Recognitions

  • 2013 - Fellow of the American Chemical Society
  • 2008 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Frank M. Raushel is affiliated with Texas A&M University in the United States. Their research work spans extensively across the fields of Biochemistry, Genetics, and Molecular Biology, with a substantial focus on Molecular Biology, Materials Chemistry, Organic Chemistry, Food Science, and Infectious Diseases.

The scientist's research topics include:

  • Enzyme Structure and Function
  • Carbohydrate Chemistry and Synthesis
  • Salmonella and Campylobacter Epidemiology
  • Bacteriophages and Microbial Interactions
  • Glycosylation and Glycoproteins Research
  • Probiotics and Fermented Foods
  • Biochemical and Molecular Research

Frank M. Raushel has contributed publications in several venues, with the most frequent being Biochemistry, followed by other journals such as bioRxiv (Cold Spring Harbor Laboratory), ACS Chemical Biology, Biosensors and Bioelectronics, and JACS Au.

Selected recent publications include:

  • A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells, 2021, ACS Chemical Biology
  • Textile-based wearable solid-contact flexible fluoride sensor: Toward biodetection of G-type nerve agents, 2021, Biosensors and Bioelectronics
  • A Chemoenzymatic Synthesis of the (RP)-Isomer of the Antiviral Prodrug Remdesivir, 2020, Biochemistry
  • Structural Analysis of Cj1427, an Essential NAD-Dependent Dehydrogenase for the Biosynthesis of the Heptose Residues in the Capsular Polysaccharides of Campylobacter jejuni, 2020, Biochemistry
  • Biosynthesis of d-glycero-l-gluco-Heptose in the Capsular Polysaccharides of Campylobacter jejuni, 2021, Biochemistry

Frequent collaborators in their research include Tamari Narindoshvili, Dao Feng Xiang, Manas K. Ghosh, Jamison P. Huddleston, and Hazel M. Holden.

Frank M. Raushel has been recognized as a Fellow of the American Chemical Society in 2013 and as a Fellow of the American Association for the Advancement of Science (AAAS) in 2008.

Best Publications

  • Purification and properties of the phosphotriesterase from Pseudomonas diminuta.

    D P Dumas;S R Caldwell;J R Wild;F M Raushel

  • Characterization of the zinc binding site of bacterial phosphotriesterase.

    G A Omburo;J M Kuo;L S Mullins;F M Raushel

  • Channeling of Substrates and Intermediates in Enzyme-Catalyzed Reactions

    Xinyi Huang;Hazel M. Holden;Frank M. Raushel

  • Structural and catalytic diversity within the amidohydrolase superfamily.

    Clara M. Seibert;Frank M. Raushel

  • Structure of carbamoyl phosphate synthetase : a journey of 96 A from substrate to product

    James B. Thoden;Hazel M. Holden;Gary Wesenberg;Frank M. Raushel

  • Mechanism for the hydrolysis of organophosphates by the bacterial phosphotriesterase.

    Sarah D. Aubert;Yingchun Li;Frank M. Raushel

  • Three-dimensional structure of the zinc-containing phosphotriesterase with the bound substrate analog diethyl 4-methylbenzylphosphonate.

    Janeen L. Vanhooke;Matthew M. Benning;Frank M. Raushel;Hazel M. Holden

  • Inactivation of organophosphorus nerve agents by the phosphotriesterase from Pseudomonas diminuta.

    David P. Dumas;H.Dupont Durst;Wayne G. Landis;Frank M. Raushel

  • Structure-activity relationships in the hydrolysis of substrates by the phosphotriesterase from Pseudomonas diminuta.

    William J. Donarski;David P. Dumas;David P. Heitmeyer;Vincent E. Lewis

  • Structure-based activity prediction for an enzyme of unknown function

    Johannes C. Hermann;Ricardo Marti-Arbona;Alexander A. Fedorov;Elena Fedorov

  • Bacterial detoxification of organophosphate nerve agents.

    Frank M Raushel

  • Three-dimensional structure of the binuclear metal center of phosphotriesterase

    Matthew M. Benning;Jane M. Kuo;Frank M. Raushel;Hazel M. Holden

  • High resolution X-ray structures of different metal-substituted forms of phosphotriesterase from Pseudomonas diminuta.

    Matthew M. Benning;Hyunbo Shim;Frank M. Raushel;Hazel M. Holden

  • Three-dimensional structure of phosphotriesterase: an enzyme capable of detoxifying organophosphate nerve agents.

    Matthew M. Benning;Jane M. Kuo;Frank M. Raushel;Hazel M. Holden

  • Limits of diffusion in the hydrolysis of substrates by the phosphotriesterase from Pseudomonas diminuta

    Steven R. Caldwell;Jennifer R. Newcomb;Kristina A. Schlecht;Frank M. Raushel

  • Catalytic Mechanisms for Phosphotriesterases

    Andrew N. Bigley;Frank M. Raushel

  • Mechanism and stereochemical course at phosphorus of the reaction catalyzed by a bacterial phosphotriesterase.

    Vincent E. Lewis;William J. Donarski;James R. Wild;Frank M. Raushel

  • Molecular structure of dihydroorotase: a paradigm for catalysis through the use of a binuclear metal center.

    James B. Thoden;George N. Phillips;Tamiko M. Neal;Frank M. Raushel

  • Enhancement, relaxation, and reversal of the stereoselectivity for phosphotriesterase by rational evolution of active site residues.

    Misty Chen-Goodspeed;Miguel A. Sogorb;Feiyue Wu;Frank M. Raushel

  • Enzymes with molecular tunnels.

    Frank M. Raushel;James B. Thoden;Hazel M. Holden

Frequent Co-Authors

Hazel M. Holden
Hazel M. Holden University of Wisconsin–Madison
James B. Thoden
James B. Thoden University of Wisconsin–Madison
Brian K. Shoichet
Brian K. Shoichet University of California, San Francisco
Steven C. Almo
Steven C. Almo Albert Einstein College of Medicine
Stephen K. Burley
Stephen K. Burley Rutgers, The State University of New Jersey
Thomas O. Baldwin
Thomas O. Baldwin University of California, Riverside
Andrej Sali
Andrej Sali University of California, San Francisco
Ivan Rayment
Ivan Rayment University of Wisconsin–Madison
W. W. Cleland
W. W. Cleland University of Wisconsin–Madison
Patricia C. Babbitt
Patricia C. Babbitt University of California, San Francisco

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