World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
77
Citations
23247
World Ranking
3975
National Ranking
1265

Biology and Biochemistry

D-Index
77
Citations
23275
World Ranking
4740
National Ranking
2295

Overview

Hazel M. Holden is affiliated with the University of Wisconsin-Madison in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with additional contributions to materials science.

The scientist's work spans several subfields including:

  • Materials Chemistry
  • Molecular Biology
  • Immunology
  • Organic Chemistry
  • Biochemistry

Main topics covered in their research include:

  • Enzyme Structure and Function
  • Carbohydrate Chemistry and Synthesis
  • Amino Acid Enzymes and Metabolism
  • Bacteriophages and microbial interactions
  • Glycosylation and Glycoproteins Research
  • Biochemical and Molecular Research
  • Diet, Metabolism, and Disease

Hazel M. Holden has contributed to numerous publications in several notable venues. The most frequent publication venues are:

  • Biochemistry (7 publications)
  • Protein Science (6 publications)
  • Journal of Biological Chemistry (3 publications)
  • Proteins Structure Function and Bioinformatics (2 publications)
  • ACS Chemical Biology (1 publication)

Recent papers published by Hazel M. Holden include:

  • Structural Analysis of Cj1427, an Essential NAD-Dependent Dehydrogenase for the Biosynthesis of the Heptose Residues in the Capsular Polysaccharides of Campylobacter jejuni, 2020, Biochemistry
  • Biosynthesis of d-glycero-l-gluco-Heptose in the Capsular Polysaccharides of Campylobacter jejuni, 2021, Biochemistry
  • C3- and C3/C5-Epimerases Required for the Biosynthesis of the Capsular Polysaccharides from Campylobacter jejuni, 2022, Biochemistry
  • 4-Deoxy-4-fluoro-GalNAz (4FGalNAz) Is a Metabolic Chemical Reporter of O-GlcNAc Modifications, Highlighting the Notable Substrate Flexibility of O-GlcNAc Transferase, 2021, ACS Chemical Biology
  • Biochemical analysis of a sugar 4,6-dehydratase from Acanthamoeba polyphaga Mimivirus, 2020, Protein Science

Frequent collaborators of Hazel M. Holden include:

  • James B. Thoden
  • Frank M. Raushel
  • Manas K. Ghosh
  • Dao Feng Xiang
  • Justin D. Ferek

Best Publications

  • Three-dimensional structure of myosin subfragment-1: a molecular motor

    Ivan Rayment;Wojciech R. Rypniewski;Karen Schmidt-Bäse;Karen Schmidt-Bäse;Robert Smith

  • Structure of the actin-myosin complex and its implications for muscle contraction.

    Ivan Rayment;Hazel M. Holden;Michael Whittaker;Christopher B. Yohn

  • X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP.BeFx and MgADP.AlF4-.

    Andrew J Fisher;Clyde A. Smith;James B. Thoden;Robert Smith

  • Structure and Function of Enzymes of the Leloir Pathway for Galactose Metabolism

    Hazel M. Holden;Ivan Rayment;James B. Thoden

  • Channeling of Substrates and Intermediates in Enzyme-Catalyzed Reactions

    Xinyi Huang;Hazel M. Holden;Frank M. Raushel

  • Three-dimensional atomic model of F-actin decorated with Dictyostelium myosin S1

    Rasmus R. Schröder;Dietmar J. Manstein;Werner Jahn;Hazel M. Holden

  • Structure of carbamoyl phosphate synthetase : a journey of 96 A from substrate to product

    James B. Thoden;Hazel M. Holden;Gary Wesenberg;Frank M. Raushel

  • Three-dimensional structure of the zinc-containing phosphotriesterase with the bound substrate analog diethyl 4-methylbenzylphosphonate.

    Janeen L. Vanhooke;Matthew M. Benning;Frank M. Raushel;Hazel M. Holden

  • Three-dimensional structure of the binuclear metal center of phosphotriesterase

    Matthew M. Benning;Jane M. Kuo;Frank M. Raushel;Hazel M. Holden

  • High resolution X-ray structures of different metal-substituted forms of phosphotriesterase from Pseudomonas diminuta.

    Matthew M. Benning;Hyunbo Shim;Frank M. Raushel;Hazel M. Holden

  • Three-dimensional structure of phosphotriesterase: an enzyme capable of detoxifying organophosphate nerve agents.

    Matthew M. Benning;Jane M. Kuo;Frank M. Raushel;Hazel M. Holden

  • Molecular structure of an apolipoprotein determined at 2.5-A resolution.

    Deborah R. Breiter;Michael R. Kanost;Matthew M. Benning;Gary Wesenberg

  • Slow- and fast-binding inhibitors of thermolysin display different modes of binding: crystallographic analysis of extended phosphonamidate transition-state analogues.

    Hazel M. Holden;Dale E. Tronrud;Arthur F. Monzingo;Larry H. Weaver

  • Structural interpretation of the mutations in the beta-cardiac myosin that have been implicated in familial hypertrophic cardiomyopathy.

    Ivan Rayment;Hazel M. Holden;James R. Sellers;Lameh Fananapazir

  • Structure of rabbit muscle pyruvate kinase complexed with Mn2+, K+, and pyruvate.

    T M Larsen;L T Laughlin;H M Holden;I Rayment

  • The molecular structure of insecticyanin from the tobacco hornworm Manduca sexta L. at 2.6 A resolution.

    H. M. Holden;W. R. Rypniewski;J. H. Law;I. Rayment

  • Three-dimensional structure of Escherichia coli asparagine synthetase B: a short journey from substrate to product.

    Todd M. Larsen;Susan K. Boehlein;Sheldon M. Schuster;Nigel G. J. Richards

  • Molecular structure of dihydroorotase: a paradigm for catalysis through the use of a binuclear metal center.

    James B. Thoden;George N. Phillips;Tamiko M. Neal;Frank M. Raushel

  • Three-dimensional structure of the biotin carboxylase subunit of acetyl-CoA carboxylase.

    Grover L. Waldrop;Ivan Rayment;Hazel M. Holden

  • Crystallization and structure determination to 2.5-A resolution of the oxidized [2Fe-2S] ferredoxin isolated from Anabaena 7120.

    Wojciech R. Rypniewski;Deborah R. Breiter;Matthew M. Benning;Gary Wesenberg

Frequent Co-Authors

James B. Thoden
James B. Thoden University of Wisconsin–Madison
Frank M. Raushel
Frank M. Raushel Texas A&M University
Ivan Rayment
Ivan Rayment University of Wisconsin–Madison
Terrance E. Meyer
Terrance E. Meyer University of Arizona
John L. Markley
John L. Markley University of Wisconsin–Madison
Debra Dunaway-Mariano
Debra Dunaway-Mariano University of New Mexico
Michael A. Cusanovich
Michael A. Cusanovich University of Arizona
Michel Gilbert
Michel Gilbert National Academies of Sciences, Engineering, and Medicine
Hector F. DeLuca
Hector F. DeLuca University of Wisconsin–Madison
John H. Law
John H. Law University of Arizona

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