World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
55
Citations
10107
World Ranking
12207
National Ranking
3260

Biology and Biochemistry

D-Index
55
Citations
10114
World Ranking
15134
National Ranking
6327

Overview

James B. Thoden is affiliated with the University of Wisconsin-Madison in the United States. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with significant contributions to materials science. Within these broader disciplines, their subfields of study include materials chemistry, molecular biology, immunology, organic chemistry, and biochemistry.

The scientist's published work touches on several key topics, including enzyme structure and function, carbohydrate chemistry and synthesis, amino acid enzymes and metabolism, bacteriophages and microbial interactions, glycosylation and glycoproteins research, biochemical and molecular research, as well as diet, metabolism, and disease.

James B. Thoden has contributed to numerous research articles, with notable papers including:

  • Structural Analysis of Cj1427, an Essential NAD-Dependent Dehydrogenase for the Biosynthesis of the Heptose Residues in the Capsular Polysaccharides of Campylobacter jejuni (2020, Biochemistry)
  • Biosynthesis of d-glycero-l-gluco-Heptose in the Capsular Polysaccharides of Campylobacter jejuni (2021, Biochemistry)
  • C3- and C3/C5-Epimerases Required for the Biosynthesis of the Capsular Polysaccharides from Campylobacter jejuni (2022, Biochemistry)
  • 4-Deoxy-4-fluoro-GalNAz (4FGalNAz) Is a Metabolic Chemical Reporter of O-GlcNAc Modifications, Highlighting the Notable Substrate Flexibility of O-GlcNAc Transferase (2021, ACS Chemical Biology)
  • Biochemical analysis of a sugar 4,6-dehydratase from Acanthamoeba polyphaga Mimivirus (2020, Protein Science)

James B. Thoden frequently collaborates with other researchers. Their main coauthors include:

  • Hazel M. Holden
  • Frank M. Raushel
  • Manas K. Ghosh
  • Dao Feng Xiang
  • Justin D. Ferek

Their publications have appeared predominantly in the following venues:

  • Biochemistry
  • Protein Science
  • Journal of Biological Chemistry
  • Proteins Structure Function and Bioinformatics
  • ACS Chemical Biology

Best Publications

  • X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP.BeFx and MgADP.AlF4-.

    Andrew J Fisher;Clyde A. Smith;James B. Thoden;Robert Smith

  • Structure and Function of Enzymes of the Leloir Pathway for Galactose Metabolism

    Hazel M. Holden;Ivan Rayment;James B. Thoden

  • Structure of carbamoyl phosphate synthetase : a journey of 96 A from substrate to product

    James B. Thoden;Hazel M. Holden;Gary Wesenberg;Frank M. Raushel

  • Three-dimensional structure of Escherichia coli asparagine synthetase B: a short journey from substrate to product.

    Todd M. Larsen;Susan K. Boehlein;Sheldon M. Schuster;Nigel G. J. Richards

  • X-ray structures of the MgADP, MgATPgammaS, and MgAMPPNP complexes of the Dictyostelium discoideum myosin motor domain.

    Andrew M. Gulick;Cary B. Bauer;James B. Thoden;Ivan Rayment

  • Molecular structure of dihydroorotase: a paradigm for catalysis through the use of a binuclear metal center.

    James B. Thoden;George N. Phillips;Tamiko M. Neal;Frank M. Raushel

  • The 1.5-A resolution crystal structure of bacterial luciferase in low salt conditions.

    Andrew J. Fisher;Thomas B. Thompson;James B. Thoden;Thomas O. Baldwin

  • Enzymes with molecular tunnels.

    Frank M. Raushel;James B. Thoden;Hazel M. Holden

  • Structural studies of myosin:nucleotide complexes: a revised model for the molecular basis of muscle contraction.

    A J Fisher;C A Smith;J Thoden;R Smith

  • Molecular structure of the NADH/UDP-glucose abortive complex of UDP-galactose 4-epimerase from Escherichia coli: implications for the catalytic mechanism.

    James B. Thoden;Perry A. Frey;Hazel M. Holden

  • Crystallographic evidence for Tyr 157 functioning as the active site base in human UDP-galactose 4-epimerase.

    James B. Thoden;Travis M. Wohlers;Judith L. Fridovich-Keil;Hazel M. Holden

  • CRYSTAL STRUCTURES OF THE OXIDIZED AND REDUCED FORMS OF UDP-GALACTOSE 4-EPIMERASE ISOLATED FROM ESCHERICHIA COLI

    James B. Thoden;Perry A. Frey;Hazel M. Holden

  • Mechanistic roles of tyrosine 149 and serine 124 in UDP-galactose 4-epimerase from Escherichia coli.

    Yijeng Liu;James B. Thoden;Jeongmin Kim;Elizabeth Berger

  • Rhodococcus L-phenylalanine dehydrogenase: kinetics, mechanism, and structural basis for catalytic specificity.

    Norbert M. W. Brunhuber;James B. Thoden;John S. Blanchard;Janeen L. Vanhooke

  • Enhanced degradation of chemical warfare agents through molecular engineering of the phosphotriesterase active site.

    Craig M. Hill;Wen-Shan Li;James B. Thoden;Hazel M. Holden

  • Movement of the biotin carboxylase B-domain as a result of ATP binding.

    James B. Thoden;Carol Z. Blanchard;Hazel M. Holden;Grover L. Waldrop

  • Human UDP-galactose 4-Epimerase ACCOMMODATION OF UDP-N-ACETYLGLUCOSAMINE WITHIN THE ACTIVE SITE

    James B. Thoden;Travis M. Wohlers;Judith L. Fridovich-Keil;Hazel M. Holden

  • X-ray structures of the apo and MgATP-bound states of Dictyostelium discoideum myosin motor domain.

    Cary B. Bauer;Hazel M. Holden;James B. Thoden;Robert Smith

  • Structural analysis of UDP-sugar binding to UDP-galactose 4-epimerase from Escherichia coli.

    James B. Thoden;Adrian D. Hegeman;Gary Wesenberg;Marie C. Chapeau

  • Galactokinase: structure, function and role in type II galactosemia.

    H. M. Holden;J. B. Thoden;D. J. Timson;R. J. Reece

  • The amidotransferase family of enzymes: molecular machines for the production and delivery of ammonia.

    Frank M. Raushel;James B. Thoden;Hazel M. Holden

Frequent Co-Authors

Hazel M. Holden
Hazel M. Holden University of Wisconsin–Madison
Frank M. Raushel
Frank M. Raushel Texas A&M University
Ivan Rayment
Ivan Rayment University of Wisconsin–Madison
Michel Gilbert
Michel Gilbert National Academies of Sciences, Engineering, and Medicine
Lawrence F. Dahl
Lawrence F. Dahl University of Wisconsin–Madison
Debra Dunaway-Mariano
Debra Dunaway-Mariano University of New Mexico
N. Martin Young
N. Martin Young National Research Council Canada
Jorge C. Escalante-Semerena
Jorge C. Escalante-Semerena University of Georgia
Thomas O. Baldwin
Thomas O. Baldwin University of California, Riverside
Gregory A. Grant
Gregory A. Grant Washington University in St. Louis

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