World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
45
Citations
8635
World Ranking
16335
National Ranking
4069

Overview

Karen N. Allen is affiliated with Boston University in the United States and has a research focus primarily in the fields of Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Molecular Biology, Organic Chemistry, Biotechnology, Materials Chemistry, and Neurology.

The scientist's research covers various topics centered on biochemical and molecular processes. Key areas of work include:

  • Glycosylation and Glycoproteins Research
  • Carbohydrate Chemistry and Synthesis
  • Microbial Metabolic Engineering and Bioproduction
  • Enzyme Structure and Function
  • Enzyme Production and Characterization
  • Protein Structure and Dynamics
  • Biochemical and Molecular Research

Karen N. Allen has contributed to numerous publications across a variety of scientific journals. Frequent venues for publication include:

  • Biochemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Biological Chemistry
  • Proceedings of the National Academy of Sciences
  • Protein Science

Some of their recent published works are:

  • Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase, 2023, Science
  • Lanthanide-Binding Tags for 3D X-ray Imaging of Proteins in Cells at Nanoscale Resolution, 2020, Journal of the American Chemical Society
  • Bioinformatic Analysis of the Flavin-Dependent Amine Oxidase Superfamily: Adaptations for Substrate Specificity and Catalytic Diversity, 2020, Journal of Molecular Biology
  • Recapitulating the Binding Affinity of Nrf2 for KEAP1 in a Cyclic Heptapeptide, Guided by NMR, X-ray Crystallography, and Machine Learning, 2021, Journal of the American Chemical Society
  • Glycoconjugate pathway connections revealed by sequence similarity network analysis of the monotopic phosphoglycosyl transferases, 2021, Proceedings of the National Academy of Sciences

Frequent co-authors in Karen N. Allen's research include:

  • Barbara Imperiali
  • Adrian Whitty
  • Greg J. Dodge
  • Dean R. Tolan
  • Samantha N. Muellers

The scientist's publication record demonstrates extensive collaboration and a focus on biochemical mechanisms related to enzyme function, carbohydrate metabolism, and protein structure analysis. Their work integrates experimental and computational methods to explore molecular interactions and catalytic properties within biological systems.

Best Publications

  • Construction and Analysis of Two Genome-Scale Deletion Libraries for Bacillus subtilis

    Byoung-Mo Koo;George Kritikos;Jeremiah D. Farelli;Horia Todor

  • Evolutionary Genomics of the HAD Superfamily: Understanding the Structural Adaptations and Catalytic Diversity in a Superfamily of Phosphoesterases and Allied Enzymes

    A. Maxwell Burroughs;Karen N. Allen;Debra Dunaway-Mariano;L. Aravind

  • The Pentacovalent Phosphorus Intermediate of a Phosphoryl Transfer Reaction

    Sushmita D. Lahiri;Guofeng Zhang;Debra Dunaway-Mariano;Karen N. Allen

  • Phosphoryl group transfer: evolution of a catalytic scaffold

    Karen N. Allen;Debra Dunaway-Mariano

  • Structural Origin of the High Affinity of a Chemically Evolved Lanthanide-Binding Peptide†

    Mark Nitz;Manashi Sherawat;Katherine J. Franz;Ezra Peisach

  • An Experimental Approach to Mapping the Binding Surfaces of Crystalline Proteins

    Karen N. Allen;Cornelia R. Bellamacina;Xiaochun Ding;Constance J. Jeffery

  • The crystal structure of Bacillus cereus phosphonoacetaldehyde hydrolase: Insight into catalysis of phosphorus bond cleavage and catalytic diversification within the had enzyme superfamily

    Marc C. Morais;Wenhai Zhang;Angela S. Baker;Guofeng Zhang

  • The Enzyme Function Initiative

    John A. Gerlt;Karen N. Allen;Steven C. Almo;Richard N. Armstrong

  • Double-lanthanide-binding tags: design, photophysical properties, and NMR applications.

    Langdon J Martin;Martin J Hähnke;Mark Nitz;Jens Wöhnert

  • Panoramic view of a superfamily of phosphatases through substrate profiling

    Hua Huang;Chetanya Pandya;Chunliang Liu;Nawar F. Al-Obaidi

  • Engineering Encodable Lanthanide-Binding Tags into Loop Regions of Proteins

    Katja Barthelmes;Anne M. Reynolds;Ezra Peisach;Hendrik R. A. Jonker

  • Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

    Unknown

  • The 2.1 A structure of Torpedo californica creatine kinase complexed with the ADP-Mg(2+)-NO(3)(-)-creatine transition-state analogue complex.

    Sushmita D Lahiri;Pan-Fen Wang;Patricia C Babbitt;Michael J McLeish

  • Enzyme Promiscuity: Engine of Evolutionary Innovation*

    Chetanya Pandya;Jeremiah D. Farelli;Debra Dunaway-Mariano;Karen N. Allen

  • X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis.

    Arnon Lavie;Karen N. Allen;Gregory A. Petsko;Dagmar Ringe

  • Structures of Clostridium botulinum Neurotoxin Serotype A Light Chain Complexed with Small-Molecule Inhibitors Highlight Active-Site Flexibility.

    Nicholas R. Silvaggi;Grant E. Boldt;Mark S. Hixon;Jack P. Kennedy

  • Lanthanide-tagged proteins--an illuminating partnership.

    Karen N Allen;Barbara Imperiali

  • Caught in the act: the structure of phosphorylated beta-phosphoglucomutase from Lactococcus lactis.

    Sushmita D. Lahiri;Guofeng Zhang;Debra Dunaway-Mariano;Karen N. Allen

  • Exploring the structural origins of cryptic sites on proteins.

    Dmitri Beglov;David R. Hall;Amanda E. Wakefield;Lingqi Luo

  • Markers of fitness in a successful enzyme superfamily.

    Karen N Allen;Debra Dunaway-Mariano

  • Analysis of the Substrate Specificity Loop of the HAD Superfamily Cap Domain

    Sushmita D. Lahiri;Guofeng Zhang;Jianying Dai;Debra Dunaway-Mariano

  • The origin of the electrostatic perturbation in acetoacetate decarboxylase

    Meng-Chiao Ho;Jean-François Ménétret;Hiro Tsuruta;Karen N. Allen

Frequent Co-Authors

Debra Dunaway-Mariano
Debra Dunaway-Mariano University of New Mexico
Kim D. Janda
Kim D. Janda Scripps Research Institute
John A. Gerlt
John A. Gerlt University of Illinois at Urbana-Champaign
Harald Schwalbe
Harald Schwalbe Goethe University Frankfurt
Sandor Vajda
Sandor Vajda Boston University
Gregory A. Petsko
Gregory A. Petsko Cornell University
Dagmar Ringe
Dagmar Ringe Brandeis University
Patricia C. Babbitt
Patricia C. Babbitt University of California, San Francisco
Eric A. Johnson
Eric A. Johnson University of Wisconsin–Madison

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