World's Best Scientists 2026 revealed!
Barbara Imperiali

Barbara Imperiali

D-Index & Metrics

Chemistry

D-Index
81
Citations
19116
World Ranking
3328
National Ranking
1097

Biology and Biochemistry

D-Index
81
Citations
19031
World Ranking
3958
National Ranking
1950

Research.com Recognitions

  • 2010 - Member of the National Academy of Sciences
  • 2001 - Fellow of the American Academy of Arts and Sciences
  • 1993 - Fellow of Alfred P. Sloan Foundation

Overview

Barbara Imperiali is affiliated with the Massachusetts Institute of Technology (MIT) in the United States. Their research primarily spans the field of Biochemistry, Genetics, and Molecular Biology, with a focus on several subfields including Molecular Biology, Organic Chemistry, Biotechnology, Genetics, and Ecology.

The main topics of their work are diverse and include:

  • Glycosylation and Glycoproteins Research
  • Carbohydrate Chemistry and Synthesis
  • Enzyme Production and Characterization
  • Bacterial Genetics and Biotechnology
  • Bacteriophages and microbial interactions
  • Monoclonal and Polyclonal Antibodies Research
  • RNA and protein synthesis mechanisms

Barbara Imperiali has contributed multiple research articles in leading scientific journals. Some recent representative papers are:

  • "Lanthanide-Binding Tags for 3D X-ray Imaging of Proteins in Cells at Nanoscale Resolution," 2020, Journal of the American Chemical Society
  • "Strategies and Tactics for the Development of Selective Glycan-Binding Proteins," 2021, ACS Chemical Biology
  • "Glycoconjugate pathway connections revealed by sequence similarity network analysis of the monotopic phosphoglycosyl transferases," 2021, Proceedings of the National Academy of Sciences
  • "The surprising structural and mechanistic dichotomy of membrane-associated phosphoglycosyl transferases," 2021, Biochemical Society Transactions
  • "Defining early steps in Bacillus subtilis biofilm biosynthesis," 2023, mBio

Their frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Biological Chemistry
  • Biopolymers
  • Protein Science
  • ACS Chemical Biology

Frequent collaborators in research have been:

  • Greg J. Dodge
  • Karen N. Allen
  • Christine A. Arbour
  • Hannah M. Bernstein
  • Soumi Ghosh

Barbara Imperiali's recognitions include election as a Member of the National Academy of Sciences in 2010, Fellowship of the American Academy of Arts and Sciences in 2001, and fellowship from the Alfred P. Sloan Foundation in 1993.

Best Publications

  • Effect of N-linked glycosylation on glycopeptide and glycoprotein structure.

    Barbara Imperiali;Sarah E O’Connor

  • Protein oligomerization: how and why.

    Mayssam H. Ali;Barbara Imperiali

  • Asparagine-linked protein glycosylation: from eukaryotic to prokaryotic systems.

    Eranthie Weerapana;Barbara Imperiali

  • Design of a monomeric 23-residue polypeptide with defined tertiary structure.

    Mary D. Struthers;Richard P. Cheng;Barbara Imperiali

  • Exploiting Polypeptide Motifs for the Design of Selective Cu(II) Ion Chemosensors

    Alicia Torrado;Grant K. Walkup;Barbara Imperiali

  • Monitoring protein interactions and dynamics with solvatochromic fluorophores

    Galen S. Loving;Matthieu Sainlos;Matthieu Sainlos;Barbara Imperiali

  • inhibition of serine proteases by peptidyl fluoromethyl ketones

    Barbara Imperiali;Robert H. Abeles

  • A Versatile Amino Acid Analogue of the Solvatochromic Fluorophore 4-N,N-Dimethylamino-1,8-naphthalimide: A Powerful Tool for the Study of Dynamic Protein Interactions

    Galen Loving;Barbara Imperiali

  • Versatile fluorescence probes of protein kinase activity.

    Melissa D. Shults;Barbara Imperiali

  • Modular and tunable chemosensor scaffold for divalent zinc.

    Melissa D Shults;Dierdre A Pearce;Barbara Imperiali

  • Derivatives of 8-hydroxy-2-methylquinoline are powerful prototypes for zinc sensors in biological systems.

    Dierdre A. Pearce;Nathalie Jotterand;Isaac S. Carrico;Barbara Imperiali

  • The Expanding Horizons of Asparagine-Linked Glycosylation

    Angelyn Larkin;Barbara Imperiali

  • Modulation of protein structure and function by asparagine-linked glycosylation

    Sarah E. O'Connor;Barbara Imperiali

  • Fluorescent Chemosensors for Divalent Zinc Based on Zinc Finger Domains. Enhanced Oxidative Stability, Metal Binding Affinity, and Structural and Functional Characterization

    Grant K. Walkup;Barbara Imperiali

  • A multiplexed homogeneous fluorescence-based assay for protein kinase activity in cell lysates.

    Melissa D Shults;Kevin A Janes;Douglas A Lauffenburger;Barbara Imperiali

  • Design and Evaluation of a Peptidyl Fluorescent Chemosensor for Divalent Zinc

    Grant K. Walkup;Barbara Imperiali

  • Lanthanide-binding tags as versatile protein coexpression probes.

    Katherine J. Franz;Mark Nitz;Barbara Imperiali

  • Photophysics and Biological Applications of the Environment-Sensitive Fluorophore 6-N,N-Dimethylamino-2,3-naphthalimide

    M. Eugenio Vazquez;Juan B. Blanco;B. Imperiali

  • Structural Origin of the High Affinity of a Chemically Evolved Lanthanide-Binding Peptide†

    Mark Nitz;Manashi Sherawat;Katherine J. Franz;Ezra Peisach

  • Stereoselective aldol condensation. Use of chiral boron enolates

    Satoru Masamune;William Choy;A J Kerdesky Francis;Barbara Imperiali

  • Conformational implications of asparagine-linked glycosylation

    Barbara Imperiali;Keith W. Rickert

Frequent Co-Authors

Karen N. Allen
Karen N. Allen Boston University
Harald Schwalbe
Harald Schwalbe Goethe University Frankfurt
Katherine J. Franz
Katherine J. Franz Duke University
Sarah E. O'Connor
Sarah E. O'Connor Max Planck Society
Eranthie Weerapana
Eranthie Weerapana Boston College
Christian P. R. Hackenberger
Christian P. R. Hackenberger Humboldt-Universität zu Berlin
Daniel Choquet
Daniel Choquet University of Bordeaux
Ken Jacobson
Ken Jacobson University of North Carolina at Chapel Hill

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