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Karlene A. Cimprich

Karlene A. Cimprich

D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
21686
World Ranking
16918
National Ranking
6971

Research.com Recognitions

  • 2015 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Karlene A. Cimprich is affiliated with Stanford University in the United States. Their research spans multiple areas within biochemistry, genetics, and molecular biology, with significant contributions also in medicine. The focus of their work covers molecular biology, oncology, epidemiology, immunology, and genetics.

The scientist's research topics include:

  • DNA Repair Mechanisms
  • CRISPR and Genetic Engineering
  • RNA and protein synthesis mechanisms
  • PARP inhibition in cancer therapy
  • Immune Cell Function and Interaction
  • Cancer-related Molecular Pathways
  • Advanced biosensing and bioanalysis techniques

Recent publications by Karlene A. Cimprich reflect active work in molecular cell biology, focusing on RNA-DNA hybrid formation, genome stability, and replication stress. Selected recent papers include:

  • "R-loop-derived cytoplasmic RNA-DNA hybrids activate an immune response" (2022, Nature)
  • "Walking a tightrope: The complex balancing act of R-loops in genome stability" (2022, Molecular Cell)
  • "HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis" (2020, Molecular Cell)
  • "qDRIP: a method to quantitatively assess RNA-DNA hybrid formation genome-wide" (2020, Nucleic Acids Research)
  • "Catalytically inactive, purified RNase H1: A specific and sensitive probe for RNA-DNA hybrid imaging" (2021, The Journal of Cell Biology)

Frequent publication venues for their work include Molecular Cell, Nature, bioRxiv (Cold Spring Harbor Laboratory), Nucleic Acids Research, and The Journal of Cell Biology.

Karlene A. Cimprich collaborates regularly with several colleagues in the field, including:

  • Magdalena P. Crossley
  • Gongshi Bai
  • Ataya Sathirachinda
  • Joshua R. Brickner
  • Chenlin Song

In recognition of career achievements, Karlene A. Cimprich was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2015.

Best Publications

  • Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

    Christine E. Canman;Dae Sik Lim;Karlene A. Cimprich;Yoichi Taya

  • Causes and consequences of replication stress.

    Michelle K. Zeman;Karlene A. Cimprich

  • ATR: an essential regulator of genome integrity

    Karlene A. Cimprich;David Cortez

  • Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint

    Tony S. Byun;Marcin Pacek;Muh-ching Yee;Johannes C. Walter

  • The essential kinase ATR: ensuring faithful duplication of a challenging genome

    Joshua C. Saldivar;David Cortez;Karlene A. Cimprich

  • Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints.

    William A. Cliby;William A. Cliby;Christopher J. Roberts;Karlene A. Cimprich;Karlene A. Cimprich;Cheri M. Stringer

  • A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability

    Renee D. Paulsen;Deena V. Soni;Roy Wollman;Angela T. Hahn

  • Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses.

    Stephan Hamperl;Michael J. Bocek;Joshua C. Saldivar;Tomek Swigut

  • R-Loops as Cellular Regulators and Genomic Threats.

    Madzia P. Crossley;Michael Bocek;Karlene A. Cimprich

  • Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability

    Julie Sollier;Caroline Townsend Stork;María L. García-Rubio;Renee D. Paulsen

  • Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells

    Gaelen T Hess;Laure Frésard;Kyuho Han;Cameron H Lee

  • An ATR- and Cdc7-Dependent DNA Damage Checkpoint that Inhibits Initiation of DNA Replication

    Vincenzo Costanzo;David Shechter;Patrick J Lupardus;Karlene A Cimprich

  • ATR phosphorylates SMARCAL1 to prevent replication fork collapse

    Frank B. Couch;Carol E. Bansbach;Robert Driscoll;Jessica W. Luzwick

  • Breaking bad: R-loops and genome integrity

    Julie Sollier;Karlene A. Cimprich

  • cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein

    Karlene A. Cimprich;Tae Bum Shin;Curtis T. Keith;Stuart L. Schreiber

  • The ATR pathway: fine-tuning the fork.

    Renee D Paulsen;Karlene A Cimprich

  • The structural determinants of checkpoint activation

    Christina A. MacDougall;Tony S. Byun;Christopher Van;Muh-ching Yee

  • The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability

    Stephan Hamperl;Karlene A. Cimprich

  • Conflict Resolution in the Genome: How Transcription and Replication Make It Work

    Stephan Hamperl;Karlene A. Cimprich

  • Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage

    Caroline Townsend Stork;Michael Bocek;Madzia P Crossley;Julie Sollier

Frequent Co-Authors

David Cortez
David Cortez Vanderbilt University
Tobias Meyer
Tobias Meyer Stanford University
Thomas J. Wandless
Thomas J. Wandless Stanford University
Frédéric Chédin
Frédéric Chédin University of California, Davis
Johannes C. Walter
Johannes C. Walter Harvard University
Rachel H. Giles
Rachel H. Giles Utrecht University
Vincenzo Costanzo
Vincenzo Costanzo University of Catania
Stuart L. Schreiber
Stuart L. Schreiber Harvard University
Jean Gautier
Jean Gautier Columbia University
William A. Cliby
William A. Cliby Mayo Clinic

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