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Thomas J. Wandless

Thomas J. Wandless

D-Index & Metrics

Biology and Biochemistry

D-Index
48
Citations
13753
World Ranking
18219
National Ranking
7446

Research.com Recognitions

  • 2000 - Fellow of Alfred P. Sloan Foundation

Overview

Thomas J. Wandless is affiliated with Stanford University in the United States. Their research primarily spans the field of Biochemistry, Genetics and Molecular Biology, with a strong focus on Molecular Biology. Additional subfields include Oncology, Immunology, Radiology, Nuclear Medicine and Imaging, and Cell Biology.

The scientist's work centers on topics such as:

  • CAR-T cell therapy research
  • Ubiquitin and proteasome pathways
  • Immune Cell Function and Interaction
  • Protein Degradation and Inhibitors
  • Advanced biosensing and bioanalysis techniques
  • Immunotherapy and Immune Responses
  • Viral Infectious Diseases and Gene Expression in Insects

Wandless has published articles in several venues, including:

  • ACS Chemical Biology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science
  • Cell chemical biology
  • Blood

Frequent coauthors in their publications include Ling-Chun Chen, Evan W. Weber, Kevin R. Parker, Elena Sotillo, and Rachel C. Lynn.

Significant recent papers by Wandless are:

  • "Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling" (2021, Science)
  • "Transient "rest" induces functional reinvigoration and epigenetic remodeling in exhausted CAR-T cells" (2020, bioRxiv (Cold Spring Harbor Laboratory))
  • "A Method for Conditional Regulation of Protein Stability in Native or Near-Native Form" (2020, Cell chemical biology)
  • "A cAMP Sensor Based on Ligand-Dependent Protein Stabilization" (2022, ACS Chemical Biology)
  • "Ubiquitin-Derived Fragment as a Peptide Linker for the Efficient Cleavage of a Target Protein from a Degron" (2024, ACS Chemical Biology)

In 2000, Wandless was named a Fellow of the Alfred P. Sloan Foundation.

Best Publications

  • Controlling signal transduction with synthetic ligands

    David M. Spencer;Thomas J. Wandless;Stuart L. Schreiber;Gerald R. Crabtree

  • A Rapid, Reversible, and Tunable Method to Regulate Protein Function in Living Cells Using Synthetic Small Molecules

    Laura A. Banaszynski;Ling chun Chen;Lystranne A. Maynard-Smith;A. G.Lisa Ooi

  • PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane.

    Won Do Heo;Takanari Inoue;Wei Sun Park;Man Lyang Kim

  • Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity.

    J. Liu;M. W. Albers;T. J. Wandless;S. Luan

  • Characterization of the FKBP.rapamycin.FRB ternary complex.

    Laura A. Banaszynski;Corey W. Liu;Thomas J. Wandless

  • Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling.

    Evan W. Weber;Kevin R. Parker;Elena Sotillo;Rachel C. Lynn

  • Probing immunosuppressant action with a nonnatural immunophilin ligand

    Barbara E. Bierer;Patricia K. Somers;Thomas J. Wandless;Steven J. Burakoff

  • An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways

    Takanari Inoue;Won Do Heo;Joshua S Grimley;Thomas J Wandless

  • FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension

    Edda Spiekerkoetter;Xuefei Tian;Jie Cai;Rachel K. Hopper

  • A General Chemical Method to Regulate Protein Stability in the Mammalian Central Nervous System

    Mari Iwamoto;Tomas Björklund;Cecilia Lundberg;Deniz Kirik

  • Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin.

    Stephen W. Michnick;Michael K. Rosen;Thomas J. Wandless;Martin Karplus

  • Potent stimulation of SH-PTP2 phosphatase activity by simultaneous occupancy of both SH2 domains.

    Scott Pluskey;Thomas J. Wandless;Christopher T. Walsh;Steven E. Shoelson

  • A Plant-Like Kinase in Plasmodium falciparum Regulates Parasite Egress from Erythrocytes

    Jeffrey D. Dvorin;Jeffrey D. Dvorin;Derek C. Martyn;Saurabh D. Patel;Saurabh D. Patel;Joshua S. Grimley

  • SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes

    Rebecca Berdeaux;Naomi Goebel;Laura Banaszynski;Hiroshi Takemori

  • Exceptionally high trans (anti) stereoselectivity in catalytic cyclopropanation reactions

    Michael P. Doyle;Vahid Bagheri;Thomas J. Wandless;Nancy K. Harn

  • Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1.

    S Sugimoto;T J Wandless;S E Shoelson;B G Neel

  • Regulated transcription of targeted genes and other biological events

    Gerald R. Crabtree;Stuart L. Schreiber;David M. Spencer;Thomas J. Wandless

  • Rapid control of protein level in the apicomplexan Toxoplasma gondii.

    Angelika Herm-Götz;Carolina Agop-Nersesian;Sylvia Münter;Joshua S Grimley

  • Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity.

    J. Henri Bayle;Joshua S. Grimley;Kryn Stankunas;Jason E. Gestwicki

  • A Cell-permeable, Activity-based Probe for Protein and Lipid Kinases

    Muh-ching Yee;Stefanie C. Fas;Michelle M. Stohlmeyer;Thomas J. Wandless

Frequent Co-Authors

Gerald R. Crabtree
Gerald R. Crabtree Stanford University
Stuart L. Schreiber
Stuart L. Schreiber Harvard University
Tobias Meyer
Tobias Meyer Stanford University
Michael K. Rosen
Michael K. Rosen The University of Texas Southwestern Medical Center
Christopher H. Contag
Christopher H. Contag Michigan State University
Stephen W. Michnick
Stephen W. Michnick University of Montreal
Karlene A. Cimprich
Karlene A. Cimprich Stanford University
Jason E. Gestwicki
Jason E. Gestwicki University of California, San Francisco
David Baker
David Baker University of Washington
Elizabeth A. Winzeler
Elizabeth A. Winzeler University of California, San Diego

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