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D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
12280
World Ranking
11434
National Ranking
4940

Overview

David M. Spencer is affiliated with Baylor College of Medicine in the United States. Their research primarily focuses on immunology and microbiology, with a particular emphasis on immunology, oncology, global and planetary change, genetics, and plant science as subfields. This interdisciplinary approach addresses both human health and environmental studies.

Spencer's work covers several main topics, including CAR-T cell therapy research, immune cell function and interaction, T-cell and B-cell immunology, virus-based gene therapy research, horticultural and viticultural research, forest ecology and management, and plant water relations and carbon dynamics.

The scientist has published in various venues, including:

  • Blood Advances
  • Molecular Therapy
  • Forests
  • Cancer Research
  • Journal of Marine Science and Technology

Frequent collaborators in their research include Aaron E. Foster, J. Henri Bayle, Xiaomei Wang, Daniel Jasinski, and Jan L. Medina.

Selected recent papers exemplify the scope and interdisciplinary nature of the research:

  • Inducible MyD88/CD40 synergizes with IL-15 to enhance antitumor efficacy of CAR-NK cells, 2020, Blood Advances
  • Engineering Tolerance toward Allogeneic CAR-T Cells by Regulation of MHC Surface Expression with Human Herpes Virus-8 Proteins, 2020, Molecular Therapy
  • Testing New Provenances of Eucalyptus polybractea: A Eucalypt Oil Mallee Adapted to Semi-Arid Environments, 2022, Forests
  • Abstract 2193: Small molecule inducible MyD88/CD40 (iMC) in CAR-T cells can repolarize M2 macrophage to an anti-tumor M1 phenotype, 2020, Cancer Research
  • Splitting The Scatter: Distinguishing Marine Organisms From Oceanographic Structures Using Acoustic Monitoring, 2021, Journal of Marine Science and Technology

The research breadth includes advancing immunotherapy techniques, such as CAR-T and CAR-NK cell therapies, while also addressing ecological and plant science challenges. The integration of immunological studies with gene therapy and environmental science reflects a comprehensive research profile.

Best Publications

  • Inducible apoptosis as a safety switch for adoptive cell therapy

    Antonio Di Stasi;Siok Keen Tey;Gianpietro Dotti;Yuriko Fujita

  • An inducible caspase 9 safety switch for T-cell therapy

    Karin C. Straathof;Martin A. Pulè;Patricia Yotnda;Gianpietro Dotti

  • Caspase-10 is an initiator caspase in death receptor signaling

    Jin Wang;Hyung J. Chun;Wilson Wong;David M. Spencer

  • WD-40 Repeat Region Regulates Apaf-1 Self-association and Procaspase-9 Activation

    Yuanming Hu;Liyun Ding;David M. Spencer;Gabriel Núñez

  • Dimeric ligands define a role for transcriptional activation domains in reinitiation

    Steffan N. Ho;Stephen R. Biggar;David M. Spencer;Stuart L. Schreiber

  • Inducible FGFR-1 Activation Leads to Irreversible Prostate Adenocarcinoma and an Epithelial-to-Mesenchymal Transition

    Victor D. Acevedo;Rama D. Gangula;Kevin W. Freeman;Rile Li

  • Synthetic activation of caspases: Artificial death switches

    Rebecca A. MacCorkle;Kevin W. Freeman;David M. Spencer

  • Distinct Inflammatory Mechanisms Mediate Early Versus Late Colitis in Mice

    David M. Spencer;Geertruida M. Veldman;Subhashis Banerjee;Joseph E. Willis

  • Combining a CD20 chimeric antigen receptor and an inducible caspase 9 suicide switch to improve the efficacy and safety of T cell adoptive immunotherapy for lymphoma.

    Lihua E. Budde;Lihua E. Budde;Lihua E. Budde;Carolina Berger;Yukang Lin;Jinjuan Wang

  • Pleiotropic biological activities of alternatively spliced TMPRSS2/ERG fusion gene transcripts.

    Jianghua Wang;Yi Cai;Yi Cai;Wendong Yu;Chengxi Ren;Chengxi Ren

  • Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation

    Xiaoou Zhou;Gianpietro Dotti;Robert A. Krance;Caridad A. Martinez

  • Functional analysis of Fas signaling in vivo using synthetic inducers of dimerization

    David M Spencer;Peter J Belshaw;Lei Chen;Steffan N Ho

  • Paths of FGFR-driven tumorigenesis

    Victor D Acevedo;Michael Ittmann;David M Spencer

  • T cells redirected against CD70 for the immunotherapy of CD70-positive malignancies

    Donald R. Shaffer;Barbara Savoldo;Zhongzhen Yi;Kevin K.H. Chow

  • Long-term outcome after haploidentical stem cell transplant and infusion of T cells expressing the inducible caspase 9 safety transgene.

    Xiaoou Zhou;Xiaoou Zhou;Antonio Di Stasi;Antonio Di Stasi;Siok Keen Tey;Siok Keen Tey;Robert A. Krance;Robert A. Krance

  • Signal transduction in T lymphocytes using a conditional allele of Sos.

    Leslie J. Holsinger;David M. Spencer;David J. Austin;Stuart L. Schreiber

  • Inducible dimerization of FGFR1: development of a mouse model to analyze progressive transformation of the mammary gland.

    Bryan E. Welm;Kevin W. Freeman;Mercy Chen;Alejandro Contreras

  • An essential role for Akt1 in dendritic cell function and tumor immunotherapy

    Dongsu Park;Natalia Lapteva;Mamatha Seethammagari;Kevin M Slawin

  • Adenovirus-mediated Tissue-targeted Expression of a Caspase-9-based Artificial Death Switch for the Treatment of Prostate Cancer

    Xiaoming Xie;Xiuqin Zhao;Yuanfang Liu;Jianfeng Zhang

  • Improved artificial death switches based on caspases and FADD.

    Liangfen Fan;Kevin W. Freeman;Tahira Khan;Elizabeth Pham

Frequent Co-Authors

Cliona M. Rooney
Cliona M. Rooney Baylor College of Medicine
Gianpietro Dotti
Gianpietro Dotti University of North Carolina at Chapel Hill
Helen E. Heslop
Helen E. Heslop Baylor College of Medicine
Malcolm K. Brenner
Malcolm K. Brenner Baylor College of Medicine
Michael Ittmann
Michael Ittmann Baylor College of Medicine
Gerald R. Crabtree
Gerald R. Crabtree Stanford University
Barbara Savoldo
Barbara Savoldo University of North Carolina at Chapel Hill
Stephen Gottschalk
Stephen Gottschalk St. Jude Children's Research Hospital
Adrian P. Gee
Adrian P. Gee Baylor College of Medicine
Stuart L. Schreiber
Stuart L. Schreiber Harvard University

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