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Overview

Linqi Shi is affiliated with Nankai University in China and has a research focus primarily in the field of Biochemistry, Genetics and Molecular Biology. Their work spans multiple subfields including Molecular Biology, Genetics, Immunology, Insect Science, and Archeology.

The scientist has contributed extensively to topics related to CRISPR and Genetic Engineering, RNA and protein synthesis mechanisms, RNA regulation and disease, and RNA Interference and Gene Delivery. Other areas covered in their research include Forensic and Genetic Research, Pluripotent Stem Cells Research, and Retinal Development and Disorders.

Linqi Shi's recent publications reflect an emphasis on genome editing, inflammation mechanisms, and neurological disease models. Selected papers include:

  • Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice (2020, Cell)
  • Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinoma (2020, Proceedings of the National Academy of Sciences)
  • Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners (2020, Nature Communications)
  • Engineered CRISPR-OsCas12f1 and RhCas12f1 with robust activities and expanded target range for genome editing (2023, Nature Communications)
  • Development of miniature base editors using engineered IscB nickase (2023, Nature Methods)

Frequent collaborators include Hui Yang, Yingsi Zhou, Jiangwei Yan, Guoling Li, and Qingquan Xiao. Linqi Shi has published multiple papers in prominent journals and venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Cell, National Science Review, and Forensic Science International Genetics.

The scientist's body of work is characterized by a substantial focus on molecular and genetic mechanisms underlying disease and gene editing technologies. Their publications contribute to the understanding of RNA biology, genome engineering tools, and pathological signaling pathways related to inflammation and fibrosis.

Best Publications

  • Nanotechnology-based antimicrobials and delivery systems for biofilm-infection control.

    Yong Liu;Yong Liu;Linqi Shi;Linzhu Su;Henny C van der Mei

  • Molecular Motion in Aggregates: Manipulating TICT for Boosting Photothermal Theranostics

    Shunjie Liu;Xin Zhou;Xin Zhou;Haoke Zhang;Hanlin Ou

  • Surface-Adaptive, Antimicrobially Loaded, Micellar Nanocarriers with Enhanced Penetration and Killing Efficiency in Staphylococcal Biofilms

    Yong Liu;Henk J Busscher;Bingran Zhao;Yuanfeng Li

  • Biomimetic enzyme nanocomplexes and their use as antidotes and preventive measures for alcohol intoxication

    Yang Liu;Juanjuan Du;Ming Yan;Mo Yin Lau

  • Phenylboronic acid-based glucose-responsive polymeric nanoparticles: synthesis and applications in drug delivery

    Rujiang Ma;Linqi Shi

  • Biomedical polymers: synthesis, properties, and applications

    Unknown

  • Thermoresponsive Micellization of Poly(ethylene glycol)-b-poly(N-isopropylacrylamide) in Water

    Wangqing Zhang;Linqi Shi;Kai Wu;Yingli An

  • Glucose-responsive micelles from self-assembly of poly(ethylene glycol)-b-poly(acrylic acid-co-acrylamidophenylboronic acid) and the controlled release of insulin.

    Beilei Wang;Rujiang Ma;Gan Liu;Yan Li

  • Synthesis of Noble Metal Nanoparticles Embedded in the Shell Layer of Core−Shell Poly(styrene-co-4-vinylpyridine) Micospheres and Their Application in Catalysis

    Fei Wen;Wangqing Zhang;Guanwei Wei;Yao Wang

  • Multistage Delivery Nanoparticle Facilitates Efficient CRISPR/dCas9 Activation and Tumor Growth Suppression In Vivo

    Qi Liu;Kai Zhao;Chun Wang;Zhanzhan Zhang

  • Lipid-Based Antimicrobial Delivery-Systems for the Treatment of Bacterial Infections

    Da-Yuan Wang;Henny C. van der Mei;Yijin Ren;Henk J. Busscher

  • Silver-Decorated Polymeric Micelles Combined with Curcumin for Enhanced Antibacterial Activity

    Fan Huang;Yang Gao;Yumin Zhang;Tangjian Cheng

  • Poly(β-Amino Esters): Synthesis, Formulations, and Their Biomedical Applications.

    Yong Liu;Yong Liu;Yuanfeng Li;Yuanfeng Li;Damla Keskin;Linqi Shi

  • Surface-adaptive zwitterionic nanoparticles for prolonged blood circulation time and enhanced cellular uptake in tumor cells.

    Hanlin Ou;Tangjian Cheng;Yumin Zhang;Jinjian Liu

  • Micellization of Thermo- and pH-Responsive Triblock Copolymer of Poly(ethylene glycol)-b-poly(4-vinylpyridine)-b-poly(N-isopropylacrylamide)

    Wangqing Zhang;Linqi Shi;Rujiang Ma;Yingli An

  • Nanocomposites Inhibit the Formation, Mitigate the Neurotoxicity, and Facilitate the Removal of β-Amyloid Aggregates in Alzheimer’s Disease Mice

    Yu Zhao;Jinquan Cai;Zichen Liu;Yansheng Li

  • Maintenance of amyloid β peptide homeostasis by artificial chaperones based on mixed-shell polymeric micelles.

    Fan Huang;Jianzu Wang;Aoting Qu;Liangliang Shen

  • Dual-Locking Nanoparticles Disrupt the PD-1/PD-L1 Pathway for Efficient Cancer Immunotherapy.

    Zhanzhan Zhang;Qixue Wang;Qi Liu;Yadan Zheng

  • Phenylboronic acid-based complex micelles with enhanced glucose-responsiveness at physiological pH by complexation with glycopolymer.

    Rujiang Ma;Hao Yang;Zhong Li;Gan Liu

  • A General Hypoxia-Responsive Molecular Container for Tumor-Targeted Therapy.

    Tian-Xing Zhang;Zhan-Zhan Zhang;Yu-Xin Yue;Xin-Yue Hu

  • Formation of complex micelles with double-responsive channels from self-assembly of two diblock copolymers.

    Guiying Li;Linqi Shi;Rujiang Ma;Yingli An

  • Responsive catalysis of thermoresponsive micelle-supported gold nanoparticles

    Yao Wang;Guangwei Wei;Wangqing Zhang;Xiaowei Jiang

  • pH/Sugar Dual Responsive Core-Cross-Linked PIC Micelles for Enhanced Intracellular Protein Delivery

    Jie Ren;Yanxin Zhang;Ju Zhang;Hongjun Gao

Frequent Co-Authors

Yingli An
Yingli An Nankai University
Wangqing Zhang
Wangqing Zhang Nankai University
Jianfeng Liu
Jianfeng Liu China-Japan Friendship Hospital
Henk J. Busscher
Henk J. Busscher University Medical Center Groningen
Henny C. van der Mei
Henny C. van der Mei University of Groningen
Chunsheng Kang
Chunsheng Kang Tianjin Medical University General Hospital
Yunfang Huang
Yunfang Huang Huaqiao University
X. X. Zhu
X. X. Zhu University of Montreal
Yunfeng Lu
Yunfeng Lu University of California, Los Angeles
Hao Wang
Hao Wang Swinburne University of Technology

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