World's Best Scientists 2026 revealed!

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Immunology

D-Index
63
Citations
20509
World Ranking
2985
National Ranking
20

Overview

Helder I. Nakaya is affiliated with the Universidade de São Paulo in Brazil. Their research spans multiple disciplines within medicine and biology, with a primary focus on infectious diseases, molecular biology, immunology, epidemiology, and public health.

The main fields of study covered by Nakaya include Medicine and Biochemistry, Genetics, and Molecular Biology. More specifically, their work addresses several specialized subfields such as Infectious Diseases, Molecular Biology, Immunology, Epidemiology, and Public Health, Environmental and Occupational Health.

Nakaya's research topics emphasize areas related to infectious agents and immune responses, notably:

  • COVID-19 Clinical Research Studies
  • SARS-CoV-2 and COVID-19 Research
  • Mosquito-borne Diseases and Control
  • Long-Term Effects of COVID-19
  • Viral Infections and Vectors
  • Immune Cells in Cancer
  • COVID-19 Epidemiological Studies

The scientist's publication record lists numerous contributions to high-impact journals and platforms. Frequent venues for their work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • SSRN Electronic Journal
  • Scientific Reports
  • The Journal of Immunology

Selected recent papers authored or coauthored by Nakaya include:

  • Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis, 2020, Cell Metabolism
  • Evolution and Epidemic Spread of SARS-CoV-2 in Brazil, 2020, Science
  • ACE2 Expression Is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19, 2020, The Journal of Infectious Diseases
  • Morphological, Cellular, and Molecular Basis of Brain Infection in COVID-19 Patients, 2022, Proceedings of the National Academy of Sciences
  • Gasdermin D Inhibition Prevents Multiple Organ Dysfunction During Sepsis by Blocking NET Formation, 2021, Blood

Nakaya collaborates frequently with a set of scientific colleagues, reflecting a collaborative research approach. Some of these frequent co-authors include:

  • Igor Salerno Filgueiras
  • Otavio Cabral-Marques
  • André N. A. Gonçalves
  • Ícaro Maia Santos de Castro
  • Claire-Anne Siegrist

Best Publications

  • Defining CD8 + T cells that provide the proliferative burst after PD-1 therapy

    Se Jin Im;Masao Hashimoto;Michael Y Gerner;Michael Y Gerner;Junghwa Lee

  • Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

    Troy D Querec;Rama Akondy;Eva K Lee;Weiping Cao

  • Programming the magnitude and persistence of antibody responses with innate immunity.

    Sudhir Pai Kasturi;Ioanna Skountzou;Randy A. Albrecht;Dimitrios Koutsonanos

  • Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis

    Ana Campos Codo;Gustavo Gastão Davanzo;Lauar de Brito Monteiro;Gabriela Fabiano de Souza

  • Systems biology of vaccination for seasonal influenza in humans

    Helder Imoto Nakaya;Jens Wrammert;Eva K Lee;Luigi Racioppi;Luigi Racioppi

  • Molecular signatures of antibody responses derived from a systems biology study of five human vaccines

    Shuzhao Li;Nadine Rouphael;Sai Duraisingham;Sandra Romero-Steiner

  • Evolution and epidemic spread of SARS-CoV-2 in Brazil.

    Darlan S. Candido;Darlan S. Candido;Ingra M. Claro;Jaqueline G. de Jesus;William M. Souza

  • Activation of β-Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine

    Santhakumar Manicassamy;Boris Reizis;Rajesh Ravindran;Helder Imoto Nakaya

  • TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination.

    Jason Z. Oh;Rajesh Ravindran;Benoit Chassaing;Frederic A. Carvalho;Frederic A. Carvalho

  • Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination

    Ali H Ellebedy;Katherine J. L Jackson;Haydn T Kissick;Helder Takashi Imoto Nakaya

  • ACE2 Expression Is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19.

    Bruna G G Pinto;Antonio E R Oliveira;Youvika Singh;Leandro Jimenez

  • The T helper type 2 response to cysteine proteases requires dendritic cell–basophil cooperation via ROS-mediated signaling

    Hua Tang;Weiping Cao;Sudhir Pai Kasturi;Rajesh Ravindran

  • Systems Analysis of Immunity to Influenza Vaccination across Multiple Years and in Diverse Populations Reveals Shared Molecular Signatures

    Helder I. Nakaya;Thomas Hagan;Sai S. Duraisingham;Eva K. Lee

  • The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation

    Rajesh Ravindran;Jens Loebbermann;Helder Takashi Imoto Nakaya;Nooruddin Khan

  • Phenotype, Function, and Gene Expression Profiles of Programmed Death-1hi CD8 T Cells in Healthy Human Adults

    Jaikumar Duraiswamy;Chris Ibegbu;David Masopust;Joseph Darrell Miller

  • Systems analysis of protective immune responses to RTS,S malaria vaccination in humans

    Dmitri Kazmin;Helder I Nakaya;Eva K Lee;Matthew J Johnson

  • Metabolic Phenotypes of Response to Vaccination in Humans

    Shuzhao Li;Nicole L. Sullivan;Nadine Rouphael;Tianwei Yu

  • Dengue Virus Infection Induces Expansion of a CD14+CD16+ Monocyte Population that Stimulates Plasmablast Differentiation

    Marcin Kwissa;Helder I. Nakaya;Helder I. Nakaya;Nattawat Onlamoon;Jens Wrammert;Jens Wrammert

  • Systems vaccinology: Probing humanity’s diverse immune systems with vaccines

    Bali Pulendran

  • Vaccine Activation of the Nutrient Sensor GCN2 in Dendritic Cells Enhances Antigen Presentation

    Rajesh Ravindran;Nooruddin Khan;Nooruddin Khan;Helder I. Nakaya;Helder I. Nakaya;Shuzhao Li

Frequent Co-Authors

Bali Pulendran
Bali Pulendran Stanford University
Andreas Suhrbier
Andreas Suhrbier QIMR Berghofer Medical Research Institute
Rafi Ahmed
Rafi Ahmed Emory University
Sergio Verjovski-Almeida
Sergio Verjovski-Almeida Universidade de São Paulo
Jorge Kalil
Jorge Kalil Universidade de São Paulo
Nuno Rodrigues Faria
Nuno Rodrigues Faria Imperial College London
Edecio Cunha-Neto
Edecio Cunha-Neto Universidade de São Paulo
Ester C. Sabino
Ester C. Sabino Universidade de São Paulo
Bruno B. Andrade
Bruno B. Andrade Oswaldo Cruz Foundation
Ana Tereza Ribeiro de Vasconcelos
Ana Tereza Ribeiro de Vasconcelos National Laboratory of Scientific Computing

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