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D-Index & Metrics

Biology and Biochemistry

D-Index
75
Citations
21469
World Ranking
5285
National Ranking
41

Overview

Michael Freissmuth is affiliated with the Medical University of Vienna in Austria, with a research portfolio primarily spanning biochemistry, genetics, molecular biology, medicine, and neuroscience. The scientist's work integrates a diverse array of subjects within these fields, emphasizing molecular biology, cellular and molecular neuroscience, cell biology, clinical biochemistry, and pharmacology.

Their research activities cover several main topics, notably receptor mechanisms and signaling, neuroscience and neuropharmacology research, ion channel regulation and function, neurotransmitter receptor influence on behavior, metabolism and genetic disorders, muscle metabolism and nutrition, and computational drug discovery methods.

Freissmuth's recent publications include:

  • Natural products in drug discovery: advances and opportunities (2021, Nature Reviews Drug Discovery)
  • Against all odds-the persistent popularity of homeopathy (2020, Wiener klinische Wochenschrift)
  • Functional and Biochemical Consequences of Disease Variants in Neurotransmitter Transporters: A Special Emphasis on Folding and Trafficking Deficits (2020, Pharmacology & Therapeutics)
  • Gene therapy restores dopamine transporter expression and ameliorates pathology in iPSC and mouse models of infantile parkinsonism (2021, Science Translational Medicine)
  • The Creatine Transporter Unfolded: A Knotty Premise in the Cerebral Creatine Deficiency Syndrome (2020, Frontiers in Synaptic Neuroscience)

Freissmuth collaborates frequently with several researchers, including Walter Sandtner, Ali El-Kasaby, Sonja Sučić, Shreyas Bhat, and Harald H. Sitte. This network of coauthors reflects an interdisciplinary approach within molecular pharmacology and neuroscience contexts.

Primary publication venues for Freissmuth's work exhibit a focus on both preprint and peer-reviewed journals, with a notable number of contributions to bioRxiv (Cold Spring Harbor Laboratory), Molecular Pharmacology, Frontiers in Physiology, Frontiers in Pharmacology, and Biophysical Journal.

The scientist's output emphasizes molecular and cellular mechanisms underlying receptor and neurotransmitter function, incorporating biochemical and genetic methods to explore physiological and pathological processes. Areas such as ion channel regulation and neuropharmacology are recurrent themes, reflecting a broad interest in both fundamental biology and translational research.

Best Publications

  • Natural products in drug discovery: advances and opportunities.

    Atanas G Atanasov;Sergey B Zotchev;Verena M Dirsch

  • G proteins control diverse pathways of transmembrane signaling.

    Michael Freissmuth;Patrick J. Casey;Alfred G. Gilman

  • Laryngeal recurrent nerve injury in surgery for benign thyroid diseases: effect of nerve dissection and impact of individual surgeon in more than 27,000 nerves at risk.

    Michael Hermann;Gunter Alk;Rudolf Roka;Karl Glaser

  • A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis.

    Karoline Kollmann;Gerwin Heller;Christine Schneckenleithner;Wolfgang Warsch

  • Adenosine receptors: G protein-mediated signalling and the role of accessory proteins

    Markus Klinger;Michael Freissmuth;Christian Nanoff

  • Neuromonitoring in thyroid surgery: Prospective evaluation of intraoperative electrophysiological responses for the prediction of recurrent laryngeal nerve injury

    Michael Hermann;Christa Hellebart;Michael Freissmuth

  • Expression of Gsα in Escherichia coli: Purification and properties of two forms of the protein

    M P Graziano;M Freissmuth;A G Gilman

  • Amphetamines, new psychoactive drugs and the monoamine transporter cycle

    Harald H. Sitte;Michael Freissmuth

  • Mutations of GS alpha designed to alter the reactivity of the protein with bacterial toxins. Substitutions at ARG187 result in loss of GTPase activity.

    M Freissmuth;M Freissmuth;A G Gilman

  • Oligomerization of the Human Serotonin Transporter and of the Rat GABA Transporter 1 Visualized by Fluorescence Resonance Energy Transfer Microscopy in Living Cells

    Johannes A. Schmid;Petra Scholze;Oliver Kudlacek;Michael Freissmuth

  • Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity

    B. Chanrion;C. Mannoury la Cour;F. Bertaso;M. Lerner-Natoli

  • STIMULATION OF THE MITOGEN-ACTIVATED PROTEIN KINASE VIA THE A2A-ADENOSINE RECEPTOR IN PRIMARY HUMAN ENDOTHELIAL CELLS

    Veronika Sexl;Gudrun Mancusi;Christoph Höller;Eva Gloria-Maercker

  • Risk factors for postoperative bleeding after thyroid surgery

    R. Promberger;J. Ott;F. Kober;C. Koppitsch

  • Reverse intrinsic activity of antagonists on G protein-coupled receptors

    Wolfgang Schütz;Michael Freissmuth

  • Calmodulin dependence of presynaptic metabotropic glutamate receptor signaling.

    V. O'Connor;O. El Far;E. Bofill-Cardona;C. Nanoff

  • Suramin analogues as subtype-selective G protein inhibitors.

    M Freissmuth;S Boehm;W Beindl;P Nickel

  • G protein antagonists

    Michael Freissmuth;Maria Waldhoer;Elisa Bofill-Cardona;Christian Nanoff

  • GSALPHA -SELECTIVE G PROTEIN ANTAGONISTS

    M. Hohenegger;M. Waldhoer;W. Beindl;B. Böing

  • STAT1 acts as a tumor promoter for leukemia development

    Boris Kovacic;Dagmar Stoiber;Richard Moriggl;Eva Weisz

  • Functional expression of the human serotonin 5-HT1A receptor in Escherichia coli. Ligand binding properties and interaction with recombinant G protein alpha-subunits.

    B Bertin;M Freissmuth;R M Breyer;W Schütz

Frequent Co-Authors

Harald H. Sitte
Harald H. Sitte Medical University of Vienna
Veronika Sexl
Veronika Sexl University of Innsbruck
Stefan Boehm
Stefan Boehm Medical University of Vienna
Amy Hauck Newman
Amy Hauck Newman National Institutes of Health
Thomas Hummel
Thomas Hummel TU Dresden
Ulrik Gether
Ulrik Gether University of Copenhagen
Alfred G. Gilman
Alfred G. Gilman The University of Texas Southwestern Medical Center
Mathias Müller
Mathias Müller University of Veterinary Medicine Vienna
Stefano Marullo
Stefano Marullo Université Paris Cité
Peter Hinterdorfer
Peter Hinterdorfer Johannes Kepler University of Linz

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