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Christophe Ginestier

Christophe Ginestier

D-Index & Metrics

Molecular Biology

D-Index
55
Citations
23168
World Ranking
2238
National Ranking
82

Overview

Christophe Ginestier is affiliated with Inserm in France and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research spans several subfields, including molecular biology, oncology, cancer research, immunology, and pulmonary and respiratory medicine.

The scientist's work primarily focuses on topics related to genomics and chromatin dynamics, cancer cells and metastasis, epigenetics and DNA methylation, cancer genomics and diagnostics, immunotherapy and immune responses, single-cell and spatial transcriptomics, and cancer-related molecular pathways.

Recent publications authored or coauthored by Christophe Ginestier include:

  • "CD44 regulates epigenetic plasticity by mediating iron endocytosis" (2020, Nature Chemistry)
  • "XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation" (2022, Cell)
  • "Activation of lysosomal iron triggers ferroptosis in cancer" (2025, Nature)
  • "BMI1 nuclear location is critical for RAD51-dependent response to replication stress and drives chemoresistance in breast cancer stem cells" (2022, Cell Death and Disease)
  • "A stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration" (2021, Nature Communications)

Among their frequent coauthors are:

  • Emmanuelle Charafe-Jauffret
  • Julien Wicinski
  • Manon Macario
  • Véronique Chevrier
  • Rémy Castellano

Christophe Ginestier has published in several scientific venues, with multiple contributions to bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Cancer Research, iScience, and Nature Chemistry.

This profile highlights the scientist's involvement in interdisciplinary research areas combining molecular biology, cancer studies, and immunology, illustrating a broad engagement in advancing knowledge relevant to cellular mechanisms and disease pathways.

Best Publications

  • ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.

    Christophe Ginestier;Min Hee Hur;Emmanuelle Charafe-Jauffret;Florence Monville

  • Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature.

    Emmanuelle Charafe-Jauffret;Christophe Ginestier;Flora Iovino;Julien Wicinski

  • Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis.

    Emina H. Huang;Mark J. Hynes;Tao Zhang;Tao Zhang;Christophe Ginestier

  • Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts

    Suling Liu;Yang Cong;Dong Wang;Yu-Min Sun

  • CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts

    Christophe Ginestier;Suling Liu;Mark E. Diebel;Hasan Korkaya

  • Aldehyde Dehydrogenase 1–Positive Cancer Stem Cells Mediate Metastasis and Poor Clinical Outcome in Inflammatory Breast Cancer

    Emmanuelle Charafe-Jauffret;Christophe Ginestier;Flora Iovino;Carole Tarpin

  • Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks

    Suling Liu;Christophe Ginestier;Sing J. Ou;Shawn G. Clouthier

  • Gene expression profiling of breast cell lines identifies potential new basal markers

    E Charafe-Jauffret;C Ginestier;F Monville;P Finetti

  • Regulation of Mammary Stem/Progenitor Cells by PTEN/Akt/β-Catenin Signaling

    Hasan Korkaya;Amanda Paulson;Emmanuelle Charafe-Jauffret;Christophe Ginestier

  • Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian cancer stem cells that portend poor patient survival.

    Ines A. Silva;Shoumei Bai;Karen McLean;Kun Yang

  • BRCA1 regulates human mammary stem/progenitor cell fate

    Suling Liu;Christophe Ginestier;Emmanuelle Charafe-Jauffret;Hailey Foco

  • Targeting breast stem cells with the cancer preventive compounds curcumin and piperine.

    Madhuri Kakarala;Madhuri Kakarala;Dean E. Brenner;Dean E. Brenner;Hasan Korkaya;Connie Cheng

  • Salinomycin kills cancer stem cells by sequestering iron in lysosomes

    Trang Thi Mai;Ahmed Hamaï;Antje Hienzsch;Tatiana Cañeque

  • Gene expression profiling of colon cancer by DNA microarrays and correlation with histoclinical parameters.

    François Bertucci;Sébastien Salas;Séverine Eysteries;Valéry Nasser

  • Protein expression profiling identifies subclasses of breast cancer and predicts prognosis.

    Jocelyne Jacquemier;Christophe Ginestier;Jacques Rougemont;Valérie-Jeanne Bardou

  • Cancer stem cell vaccination confers significant antitumor immunity

    Ning Ning;Qin Pan;Qin Pan;Fang Zheng;Fang Zheng;Seagal Teitz-Tennenbaum

  • Retinoid signaling regulates breast cancer stem cell differentiation.

    Christophe Ginestier;Julien Wicinski;Nathalie Cervera;Florence Monville

  • Junctional recruitment of mammalian Scribble relies on E-cadherin engagement

    Christel Navarro;Sébastien Nola;Stéphane Audebert;Marie-Josée Santoni

  • Comprehensive Profiling of 8p11-12 Amplification in Breast Cancer

    Véronique Gelsi-Boyer;Béatrice Orsetti;Nathalie Cervera;Pascal Finetti

  • Typical medullary breast carcinomas have a basal/myoepithelial phenotype.

    Jocelyne Jacquemier;Laetitia Padovani;Laetitia Rabayrol;Sunil R Lakhani;Sunil R Lakhani

Frequent Co-Authors

François Bertucci
François Bertucci Aix-Marseille University
Max S. Wicha
Max S. Wicha University of Michigan–Ann Arbor
Jocelyne Jacquemier
Jocelyne Jacquemier Grenoble Alpes University
Patrice Viens
Patrice Viens Aix-Marseille University
Suling Liu
Suling Liu Fudan University
David Jérémie Birnbaum
David Jérémie Birnbaum Aix-Marseille University
Gregory J. Hannon
Gregory J. Hannon University of Cambridge

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