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Immunology

D-Index
51
Citations
17547
World Ranking
4107
National Ranking
361

Overview

Kevin J. Maloy is affiliated with the University of Oxford in the United Kingdom. Their research primarily spans the fields of Immunology and Microbiology, Medicine, and Biochemistry, Genetics and Molecular Biology. Within these fields, their work predominantly focuses on Immunology, Molecular Biology, Infectious Diseases, Public Health, Environmental and Occupational Health, and Surgery.

The scientist's main topics of research include:

  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses
  • Gut microbiota and health
  • Clostridium difficile and Clostridium perfringens research
  • Dietary Effects on Health
  • Extracellular vesicles in disease
  • Neuroinflammation and Neurodegeneration Mechanisms

Kevin J. Maloy has published extensively in several scientific venues. Their frequently used publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Reports
  • Nature Microbiology
  • Immunology
  • Mucosal Immunology

Some recent key publications by Kevin J. Maloy are:

  • Identification of gut microbial species linked with disease variability in a widely used mouse model of colitis, 2022, Nature Microbiology
  • Why do intestinal epithelial cells express MHC class II?, 2020, Immunology
  • CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T cell survival, 2022, Cell Reports
  • MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T-cell responses, 2023, Mucosal Immunology
  • Novel gut pathobionts confound results in a widely used mouse model of human inflammatory disease, 2021, bioRxiv (Cold Spring Harbor Laboratory)

Collaboration is a feature of Kevin J. Maloy's research, with frequent co-authors including:

  • Cornelia Heuberger
  • Johanna Pott
  • Claire Pearson
  • Samuel C. Forster
  • Simon Clare

The research led by Kevin J. Maloy provides insights into immune cell functions and their interactions, emphasizing intestinal immunity and gut microbiota influences. Their work contributes to the understanding of how the immune system responds to microbial and inflammatory challenges, often through studies involving mouse models of disease. This body of research intersects with neuroinflammation, infectious disease mechanisms, and the modulation of immune responses.

Best Publications

  • Intestinal homeostasis and its breakdown in inflammatory bowel disease

    Kevin J. Maloy;Fiona Powrie;Fiona Powrie

  • Regulatory T cells in the control of immune pathology.

    Kevin J. Maloy;Fiona Powrie

  • Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology

    Sofia Buonocore;Philip P. Ahern;Holm H. Uhlig;Ivaylo I. Ivanov

  • Interleukin-23 drives innate and T cell–mediated intestinal inflammation

    Sophie Hue;Philip P Ahern;Sofia Buonocore;Marika C. Kullberg

  • CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms.

    Kevin J. Maloy;Laurence Salaun;Rachel Cahill;Gordon Dougan

  • Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease

    N R West;A N Hegazy;Owens Bmj.;S J Bullers

  • IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis

    Marika C. Kullberg;Dragana Jankovic;Carl G. Feng;Sophie Hue

  • IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+ Th17 cells

    Margherita Coccia;Oliver J. Harrison;Chris Schiering;Chris Schiering;Mark J. Asquith

  • Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells

    Philip P. Ahern;Chris Schiering;Chris Schiering;Sofia Buonocore;Mandy J. McGeachy

  • Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis

    Ana Izcue;Sophie Hue;Sofia Buonocore;Carolina V. Arancibia-Cárcamo

  • Modulation of immune development and function by intestinal microbiota

    Agnieszka M. Kabat;Naren Srinivasan;Kevin J. Maloy

  • Regulatory T cells and intestinal homeostasis

    Janine L. Coombes;Nicholas J. Robinson;Kevin J. Maloy;Holm H. Uhlig;Holm H. Uhlig

  • Induction of mucosal and systemic immune responses by immunization with ovalbumin entrapped in poly(lactide-co-glycolide) microparticles.

    K J Maloy;A M Donachie;D T O'Hagan;A M Mowat

  • Intestinal Epithelial Cell Autophagy Is Required to Protect against TNF-Induced Apoptosis during Chronic Colitis in Mice.

    Johanna Pott;Agnieszka Martyna Kabat;Kevin Joseph Maloy

  • Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3⁺ Treg cell function in the intestine.

    O J Harrison;N Srinivasan;J Pott;C Schiering

  • The Intracellular Sensor NOD2 Induces MicroRNA-29 Expression in Human Dendritic Cells to Limit IL-23 Release

    Oliver Brain;Oliver Brain;Benjamin M.J. Owens;Tica Pichulik;Philip Allan;Philip Allan

  • The interleukin-23 axis in intestinal inflammation.

    Philip P. Ahern;Ana Izcue;Kevin J. Maloy;Fiona Powrie

  • Intralymphatic immunization enhances DNA vaccination

    Kevin J. Maloy;Iris Erdmann;Veronique Basch;Sophie Sierro

  • Regulating the Regulators

    Fiona Powrie;Kevin J. Maloy

  • IL-23 and Th17 cytokines in intestinal homeostasis

    K J Maloy;M C Kullberg

  • Control of intestinal inflammation by regulatory T cells.

    Christy Toms;Fiona Powrie

  • IL-1 mediates intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+Th17 cells

    M Coccia;O Harrison;C Schiering;M Asquith

Frequent Co-Authors

Fiona Powrie
Fiona Powrie University of Oxford
Allan McI. Mowat
Allan McI. Mowat University of Glasgow
Holm H. Uhlig
Holm H. Uhlig University of Oxford
Rolf M. Zinkernagel
Rolf M. Zinkernagel University of Zurich
Hans Hengartner
Hans Hengartner University of Zurich
Gordon Dougan
Gordon Dougan University of Cambridge
Richard K. Grencis
Richard K. Grencis University of Manchester
Anna Simon
Anna Simon Christian Medical College & Hospital
Simon Clare
Simon Clare Wellcome Sanger Institute
David J. Adams
David J. Adams Wellcome Sanger Institute

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