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Overview

Simon Clare is affiliated with the Wellcome Sanger Institute in the United Kingdom. Their research spans multiple areas within medicine and immunology and microbiology, with a significant focus on parasitology and infectious diseases.

The scientist's work covers several main fields of study:

  • Medicine
  • Immunology and Microbiology

Within these broader fields, Clare's research includes subfields such as:

  • Immunology
  • Epidemiology
  • Public Health, Environmental and Occupational Health
  • Molecular Biology
  • Food Science

Their research topics notably concentrate on:

  • Trypanosoma species research and implications
  • Research on Leishmaniasis Studies
  • Parasites and Host Interactions
  • Insect symbiosis and bacterial influences
  • Toxin Mechanisms and Immunotoxins
  • Gut microbiota and health
  • Probiotics and Fermented Foods

Simon Clare has collaborated frequently with several coauthors, including:

  • Cordelia Brandt
  • Katherine Harcourt
  • Gavin J. Wright
  • Charlotte Tolley
  • Delphine Autheman

Their publications appear predominantly in specialized scientific journals and preprint servers. Common publication venues for Clare include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • mBio
  • PLoS neglected tropical diseases
  • PLoS Pathogens
  • Nature

Recent notable publications by Simon Clare include:

  • "An invariant Trypanosoma vivax vaccine antigen induces protective immunity" (2021, Nature)
  • "Primary succession of Bifidobacteria drives pathogen resistance in neonatal microbiota assembly" (2024, Nature Microbiology)
  • "IRF5 Promotes Influenza Virus-Induced Inflammatory Responses in Human Induced Pluripotent Stem Cell-Derived Myeloid Cells and Murine Models" (2020, Journal of Virology)
  • "Genomics of the Argentinian cholera epidemic elucidate the contrasting dynamics of epidemic and endemic Vibrio cholerae" (2020, Nature Communications)
  • "Preclinical development of a bispecific TNFα/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease" (2021, Scientific Reports)

Best Publications

  • Requirement of bic/microRNA-155 for normal immune function.

    Antony Rodriguez;Elena Vigorito;Simon Clare;Madhuri V. Warren;Madhuri V. Warren

  • IFITM3 restricts the morbidity and mortality associated with influenza

    Aaron R. Everitt;Simon Clare;Thomas Charles Pertel;Sinu P. John

  • Targeted Restoration of the Intestinal Microbiota with a Simple, Defined Bacteriotherapy Resolves Relapsing Clostridium difficile Disease in Mice

    Trevor D. Lawley;Simon Clare;Alan W. Walker;Mark D. Stares

  • Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes

    Jacqueline K White;Anna-Karin Gerdin;Natasha A Karp;Ed Ryder

  • T cell fate and clonality inference from single-cell transcriptomes

    Michael J T Stubbington;Tapio Lönnberg;Valentina Proserpio;Simon Clare

  • The Clostridium difficile spo0A Gene Is a Persistence and Transmission Factor

    Laura J. Deakin;Simon Clare;Robert P. Fagan;Lisa F. Dawson

  • Expression of tetanus toxin Fragment C in tobacco chloroplasts

    John S. Tregoning;Peter Nixon;Hiroshi Kuroda;Zora Svab

  • Epithelial IL-22RA1-Mediated Fucosylation Promotes Intestinal Colonization Resistance to an Opportunistic Pathogen

    Tu Anh N. Pham;Simon Clare;David Goulding;Julia M. Arasteh

  • Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections

    Glen P. Carter;Anjana Chakravorty;Tu Anh Pham Nguyen;Steven Mileto

  • Proteomic and Genomic Characterization of Highly Infectious Clostridium difficile 630 Spores

    Trevor D. Lawley;Nicholas J. Croucher;Lu Yu;Simon Clare

  • Single-cell RNA-seq identifies a PD-1 hi ILC progenitor and defines its development pathway

    Yong Yu;Jason C. H. Tsang;Jason C. H. Tsang;Cui Wang;Simon Clare

  • Organ specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium.

    Siouxsie Wiles;Simon Clare;James Harker;Alan Huett

  • Genome-wide in vivo screen identifies novel host regulators of metastatic colonization.

    Louise van der Weyden;Mark J. Arends;Andrew D. Campbell;Tobias Bald;Tobias Bald

  • Gut-educated IgA plasma cells defend the meningeal venous sinuses.

    Zachary Fitzpatrick;Gordon Frazer;Ashley Ferro;Simon Clare

  • Central role for B lymphocytes and CD4(+) T cells in immunity to infection by the attaching and effacing pathogen Citrobacter rodentium

    Cameron P. Simmons;Simon Clare;Marjan Ghaem-Maghami;Tania K. Uren

  • Impaired Resistance and Enhanced Pathology During Infection with a Noninvasive, Attaching-Effacing Enteric Bacterial Pathogen, Citrobacter rodentium, in Mice Lacking IL-12 or IFN-γ

    Cameron P. Simmons;Nathalie S. Goncalves;Marjan Ghaem-Maghami;Mona Bajaj-Elliott

  • Identification of a novel Citrobacter rodentium type III secreted protein, EspI, and roles of this and other secreted proteins in infection.

    Rosanna Mundy;Liljana Petrovska;Katherine Smollett;Nandi Simpson

  • Bcl11b is essential for group 2 innate lymphoid cell development

    Jennifer A. Walker;Christopher J. Oliphant;Alexandros Englezakis;Yong Yu

  • The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development

    Yong Yu;Cui Wang;Simon Clare;Juexuan Wang

  • Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis.

    Tomas Castro-Dopico;Thomas W. Dennison;John R. Ferdinand;Rebeccah J. Mathews

Frequent Co-Authors

Gordon Dougan
Gordon Dougan University of Cambridge
David J. Adams
David J. Adams Wellcome Sanger Institute
Trevor D. Lawley
Trevor D. Lawley Wellcome Sanger Institute
Robert A. Kingsley
Robert A. Kingsley University of East Anglia
Paul Kellam
Paul Kellam Imperial College London
Nicholas R. Thomson
Nicholas R. Thomson Wellcome Sanger Institute
Sarah A. Teichmann
Sarah A. Teichmann University of Cambridge
Julian Parkhill
Julian Parkhill University of Cambridge
Stephen Baker
Stephen Baker Agency for Science, Technology and Research
John C. Marioni
John C. Marioni European Bioinformatics Institute

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