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Microbiology

D-Index
53
Citations
11769
World Ranking
4066
National Ranking
126

Overview

Dena Lyras is affiliated with Monash University in Australia and focuses on research predominantly within the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans several subfields, including Infectious Diseases, Molecular Biology, Parasitology, Ecology, and Epidemiology, reflecting a multidisciplinary approach to studying microbial and host interactions.

The scientist's main research topics cover Clostridium difficile and Clostridium perfringens, gut microbiota and health, parasitic infections and diagnostics, genomics and phylogenetic studies, bacteriophages and microbial interactions, streptococcal infections and treatments, and bacterial genetics and biotechnology.

Recent publications include:

  • The antimicrobial potential of cannabidiol, 2021, Communications Biology
  • Clostridioides difficile infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease, 2020, Proceedings of the National Academy of Sciences
  • Impact of enteric bacterial infections at and beyond the epithelial barrier, 2022, Nature Reviews Microbiology
  • Cryptosporidiosis Modulates the Gut Microbiome and Metabolism in a Murine Infection Model, 2021, Metabolites
  • Paeniclostridium (Clostridium) sordellii-associated enterocolitis in 7 horses, 2020, Journal of Veterinary Diagnostic Investigation

Dena Lyras has published frequently in venues such as bioRxiv (Cold Spring Harbor Laboratory), Microbiology Australia, Communications Biology, Nature Communications, and Preprints.org, indicating engagement with both preprint and peer-reviewed platforms in microbiology and related biomedical sciences.

Collaborations have involved several co-authors with notable frequency, including Steven J. Mileto, M. Hutton, Milena M. Awad, Meagan L. James, and Avinash V. Karpe, reflecting a network of research partnerships largely focused on infectious disease and microbial pathogenesis.

Best Publications

  • Toxin B is essential for virulence of Clostridium difficile

    Dena Lyras;Jennifer Ruth O'Connor;Pauline M Howarth;Susan P Sambol

  • Clostridium difficile infection.

    Wiep Klaas Smits;Dena Lyras;D. Borden Lacy;Mark H. Wilcox

  • Expansion of the Clostridium perfringens toxin-based typing scheme.

    Julian I. Rood;Vicki Adams;Jake Lacey;Dena Lyras

  • Epidemics of Diarrhea Caused by a Clindamycin-Resistant Strain of Clostridium difficile in Four Hospitals

    Stuart Johnson;Matthew H. Samore;Kylie A. Farrow;George E. Killgore

  • Translocation and dissemination of commensal bacteria in post-stroke infection

    Dragana Stanley;Linda J Mason;Kate E Mackin;Yogitha N Srikhanta

  • Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation

    Seth L. Masters;Seth L. Masters;Vasiliki Lagou;Isabelle Jéru;Isabelle Jéru;Paul J. Baker;Paul J. Baker

  • Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections

    Glen P. Carter;Anjana Chakravorty;Tu Anh Pham Nguyen;Steven Mileto

  • The antimicrobial potential of cannabidiol

    Mark A. T. Blaskovich;Angela M. Kavanagh;Alysha G. Elliott;Bing Zhang

  • Influence of Gastric Acid on Susceptibility to Infection with Ingested Bacterial Pathogens

    Sharon M Tennant;Elizabeth Louise Hartland;Elizabeth Louise Hartland;Tongted Phumoonna;Dena Lyras

  • Binary Toxin Production in Clostridium difficile Is Regulated by CdtR, a LytTR Family Response Regulator

    Glen Paul Carter;Dena Lyras;David Leslie Allen;Kate Mackin

  • The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia

    Carrie A. Cowardin;Erica L. Buonomo;Mahmoud M. Saleh;Madeline G. Wilson

  • Construction and analysis of chromosomal Clostridium difficile mutants

    Jennifer R. O'Connor;Dena Lyras;Kylie A. Farrow;Vicki Adams

  • The Anti-Sigma Factor TcdC Modulates Hypervirulence in an Epidemic BI/NAP1/027 Clinical Isolate of Clostridium difficile

    Glen P. Carter;Gillian R. Douce;Revathi Govind;Pauline M. Howarth

  • The role of toxin A and toxin B in the virulence of Clostridium difficile.

    Glen P. Carter;Julian I. Rood;Dena Lyras

  • Clostridium difficile virulence factors: Insights into an anaerobic spore-forming pathogen.

    Milena M Awad;Priscilla A Johanesen;Glen P Carter;Edward Rose

  • The α‐toxin of Clostridium septicum is essential for virulence

    Catherine Lydia Kennedy;Efrosinia O Krejany;Lauren Florence Young;Jennifer Ruth O'Connor

  • Environmental Response and Autoregulation of Clostridium difficile TxeR, a Sigma Factor for Toxin Gene Expression

    Nagraj Mani;Dena Lyras;Lisa Barroso;Pauline Howarth

  • Emergence of a Ribotype 244 Strain of Clostridium difficile Associated With Severe Disease and Related to the Epidemic Ribotype 027 Strain

    Sze K Lim;Rhonda Lee Stuart;Kate Elizabeth Mackin;Glen Paul Carter

  • The role of toxin A and toxin B in Clostridium difficile-associated disease: Past and present perspectives.

    Glen P Carter;Julian I Rood;Dena Lyras

  • Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β

    Man Lyang Kim;Jae Jin Chae;Yong Hwan Park;Dominic De Nardo

  • Involvement of Bacteria Other Than Clostridium difficile in Antibiotic-Associated Diarrhoea.

    Sarah Larcombe;Melanie L. Hutton;Dena Lyras

  • Familial Autoinflammation with Neutrophilic Dermatosis Reveals a Novel Regulatory Mechanism of Pyrin Activation

    P. J. Baker;V. Lagou;I. Jeru;L. Van Eyck

Frequent Co-Authors

Julian I. Rood
Julian I. Rood Monash University
Thomas V. Riley
Thomas V. Riley Edith Cowan University
Robert J. Moore
Robert J. Moore RMIT University
Dieter M. Bulach
Dieter M. Bulach University of Melbourne
James C. Whisstock
James C. Whisstock Monash University
J. Glenn Songer
J. Glenn Songer University of Arizona
Seth L. Masters
Seth L. Masters Hudson Institute of Medical Research
Roy M. Robins-Browne
Roy M. Robins-Browne University of Melbourne
Torsten Seemann
Torsten Seemann University of Melbourne

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