World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
67
Citations
14669
World Ranking
8283
National Ranking
219

Overview

Jack van Horssen is affiliated with Vrije Universiteit Amsterdam in the Netherlands and works primarily in the fields of Neuroscience, Biochemistry, Genetics and Molecular Biology, and Medicine. Their research encompasses areas such as Molecular Biology, Pathology and Forensic Medicine, Neurology, Immunology, and Developmental Neuroscience.

Their work focuses on several main topics, including:

  • Multiple Sclerosis Research Studies
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Neurogenesis and neuroplasticity mechanisms
  • Interferon and immune responses
  • Mitochondrial Function and Pathology
  • Immune Response and Inflammation
  • Immunotherapy and Immune Responses

Among recent publications, notable papers include:

  • Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders, 2021, Cellular and Molecular Life Sciences
  • Neuron-specific activation of necroptosis signaling in multiple sclerosis cortical grey matter, 2021, Acta Neuropathologica
  • Inflammation of the choroid plexus in progressive multiple sclerosis: accumulation of granulocytes and T cells, 2020, Acta Neuropathologica Communications
  • Meningeal inflammation in multiple sclerosis induces phenotypic changes in cortical microglia that differentially associate with neurodegeneration, 2021, Acta Neuropathologica
  • Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis, 2021, eLife

Frequent co-authors who have collaborated with van Horssen include:

  • Maarten E. Witte
  • Helga E. de Vries
  • Alwin Kamermans
  • Niels Hellings
  • Tim Vanmierlo

Their research has been published repeatedly in the following venues:

  • Acta Neuropathologica
  • Acta Neuropathologica Communications
  • Journal of Neuroinflammation
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cellular and Molecular Life Sciences

In addition to articles, van Horssen authored a book titled Redox-Signaling in Neurodegenerative Diseases: Biomarkers, Targets, and Therapies published in 2023 by Frontiers Media.

Best Publications

  • Progressive multiple sclerosis: pathology and pathogenesis

    Hans Lassmann;Jack van Horssen;Don Mahad

  • The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

    Jorge Ivan Alvarez;Aurore Dodelet-Devillers;Hania Kebir;Igal Ifergan

  • Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status

    Daphne Y S Vogel;Elly J F Vereyken;Judith E Glim;Priscilla D A M Heijnen

  • Nrf2-induced antioxidant protection : A promising target to counteract ROS-mediated damage in neurodegenerative disease?

    Helga E. de Vries;Maarten Witte;David Hondius;Annemieke J.M. Rozemuller

  • NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury

    Marie T. Fischer;Rakhi Sharma;Jamie L. Lim;Lukas Haider

  • Radical changes in multiple sclerosis pathogenesis.

    Jack van Horssen;Maarten E. Witte;Gerty Schreibelt;Helga E. de Vries

  • The molecular basis of neurodegeneration in multiple sclerosis

    Hans Lassmann;Jack van Horssen

  • Mitochondrial dysfunction contributes to neurodegeneration in multiple sclerosis

    Maarten E. Witte;Don J. Mahad;Hans Lassmann;Jack van Horssen

  • Mitochondrial dysfunction: a potential link between neuroinflammation and neurodegeneration?

    Maarten E. Witte;Jeroen J.G. Geurts;Helga E. de Vries;Paul van der Valk

  • Amyloid Beta Induces Oxidative Stress-Mediated Blood-Brain Barrier Changes in Capillary Amyloid Angiopathy

    Anna Carrano;Jeroen J.M. Hoozemans;Saskia M. van der Vies;Annemieke J.M. Rozemuller

  • Heparan sulphate proteoglycans in Alzheimer's disease and amyloid-related disorders

    Jack van Horssen;Pieter Wesseling;Lambert P W J van den Heuvel;Robert M W de Waal

  • Inflammation and mitochondrial dysfunction: A vicious circle in neurodegenerative disorders?

    Jack van Horssen;Pauline van Schaik;Maarten Witte

  • Enhanced number and activity of mitochondria in multiple sclerosis lesions.

    Maarten E Witte;Lars Bø;Richard J Rodenburg;Jeroen A Belien

  • The Blood-Brain Barrier in Cortical Multiple Sclerosis Lesions

    Jack van Horssen;Bianca P Brink;Helga E de Vries;Paul van der Valk

  • Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation

    Jack van Horssen;Shailender Singh;Shailender Singh;Susanne van der Pol;Markus Kipp;Markus Kipp

  • Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions.

    Ruben Van Doorn;Jack Van Horssen;Dennis Verzijl;Maarten Witte

  • Therapeutic potential and biological role of endogenous antioxidant enzymes in multiple sclerosis pathology

    Gerty Schreibelt;Jack van Horssen;Saskia van Rossum;Christine D Dijkstra

  • Oxidative stress and its impact on neurons and glia in multiple sclerosis lesions.

    Hans Lassmann;Jack van Horssen

  • Human Endogenous Retrovirus Type W Envelope Protein Inhibits Oligodendroglial Precursor Cell Differentiation

    David Kremer;Tanja Schichel;Moritz Förster;Nevena Tzekova

  • Basement membrane proteins in multiple sclerosis-associated inflammatory cuffs: potential role in influx and transport of leukocytes.

    Jack van Horssen;Lars Bö;Catharine M P Vos;Ismo Virtanen

Frequent Co-Authors

Helga E. de Vries
Helga E. de Vries University of Amsterdam
Paul van der Valk
Paul van der Valk Vrije Universiteit Amsterdam
Sandra Amor
Sandra Amor University of Amsterdam
Marcel M. Verbeek
Marcel M. Verbeek Radboud University
Niels Hellings
Niels Hellings Hasselt University
Christine D. Dijkstra
Christine D. Dijkstra VU University Medical Center
Piet Stinissen
Piet Stinissen Hasselt University
Alexandre Prat
Alexandre Prat University of Montreal
Hans Lassmann
Hans Lassmann Medical University of Vienna
Jeroen J. G. Geurts
Jeroen J. G. Geurts Vrije Universiteit Amsterdam

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