World's Best Scientists 2026 revealed!

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Immunology

D-Index
81
Citations
22889
World Ranking
1574
National Ranking
787

Medicine

D-Index
81
Citations
22891
World Ranking
16704
National Ranking
8382

Overview

Halina Offner is affiliated with Oregon Health & Science University in the United States. Their research spans several interconnected fields with a particular focus on the neuroscience and immunology interface.

Their main fields of study include:

  • Neuroscience
  • Immunology and Microbiology
  • Medicine

Within these fields, their subfields of specialization involve:

  • Immunology
  • Neurology
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience
  • Oncology

Offner's primary research topics concentrate on mechanisms related to neuroinflammation and neurodegeneration, with particular attention to:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Macrophage Migration Inhibitory Factor
  • Nuclear Receptors and Signaling
  • Neurological Disease Mechanisms and Treatments
  • Immune Response and Inflammation
  • Neurogenesis and neuroplasticity mechanisms
  • Immune cells in cancer

Notable recent publications authored or coauthored include:

  • "Cross-Talk of the CNS With Immune Cells and Functions in Health and Disease", 2021, Frontiers in Neurology
  • "Microglia and astrocyte involvement in neurodegeneration and brain cancer", 2021, Journal of Neuroinflammation
  • "Sex differences in EAE reveal common and distinct cellular and molecular components", 2020, Cellular Immunology
  • "MIF contribution to progressive brain diseases", 2024, Journal of Neuroinflammation
  • "Spleen participation in partial MHC class II construct neuroprotection in stroke", 2020, CNS Neuroscience & Therapeutics

Frequent coauthors collaborating with Offner include:

  • Arthur A. Vandenbark
  • Roberto Meza-Romero
  • Jack Wiedrick
  • Mikah S. Brandes
  • Cody J. Neff

Their work has appeared repeatedly in several publication venues, with multiple publications in:

  • Cellular Immunology
  • Metabolic Brain Disease
  • Journal of Neuroinflammation
  • Frontiers in Neurology
  • CNS Neuroscience & Therapeutics

Best Publications

  • Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis.

    Arthur A. Vandenbark;George Hashim;Halina Offner;Halina Offner

  • Experimental Stroke Induces Massive, Rapid Activation of the Peripheral Immune System:

    Halina Offner;Sandhya Subramanian;Susan M Parker;Michael E Afentoulis

  • Splenic Atrophy in Experimental Stroke Is Accompanied by Increased Regulatory T Cells and Circulating Macrophages

    Halina Offner;Halina Offner;Sandhya Subramanian;Susan M. Parker;Chunhe Wang;Chunhe Wang

  • Decreased FOXP3 levels in multiple sclerosis patients.

    Jianya Huan;Nicole Culbertson;Nicole Culbertson;Leslie Spencer;Leslie Spencer;Richard Bartholomew

  • T- and B-cell-deficient mice with experimental stroke have reduced lesion size and inflammation.

    Patricia D. Hurn;Sandhya Subramanian;Susan M. Parker;Michael E. Afentoulis

  • Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar V alpha and V beta chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different.

    F. R. Burns;Xiaobin Li;Ning Shen;H. Offner

  • Low-Dose Estrogen Therapy Ameliorates Experimental Autoimmune Encephalomyelitis in Two Different Inbred Mouse Strains

    Bruce F. Bebo;Amber Fyfe-Johnson;Kirsten Adlard;Aaron G. Beam

  • Regulatory B cells limit CNS inflammation and neurologic deficits in murine experimental stroke

    Xuefang Ren;Kozaburo Akiyoshi;Suzan Dziennis;Suzan Dziennis;Arthur A. Vandenbark;Arthur A. Vandenbark

  • Androgens alter the cytokine profile and reduce encephalitogenicity of myelin-reactive T cells.

    Bruce F. Bebo;Jeanette C. Schuster;Arthur A. Vandenbark;Arthur A. Vandenbark;Halina Offner

  • Preferential T-cell receptor beta-chain variable gene use in myelin basic protein-reactive T-cell clones from patients with multiple sclerosis.

    Brian L. Kotzin;Satyanarayana Karuturi;Yuan K. Chou;Joyce Lafferty

  • Estrogen Treatment Down-Regulates TNF-α Production and Reduces the Severity of Experimental Autoimmune Encephalomyelitis in Cytokine Knockout Mice

    Atsushi Ito;Bruce F. Bebo;Bruce F. Bebo;Agata Matejuk;Alex Zamora

  • T cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis.

    Halina Offner;George A. Hashim;Arthur A. Vandenbark

  • Treg suppressive activity involves estrogen-dependent expression of programmed death-1 (PD-1)

    Magdalena J. Polanczyk;Corwyn Hopke;Arthur A. Vandenbark;Arthur A. Vandenbark;Halina Offner;Halina Offner

  • Estrogen‐mediated immunomodulation involves reduced activation of effector T cells, potentiation of treg cells, and enhanced expression of the PD‐1 costimulatory pathway

    Magdalena J. Polanczyk;Corwyn Hopke;Arthur A. Vandenbark;Arthur A. Vandenbark;Halina Offner

  • Recombinant human β-galactoside binding lectin suppresses clinical and histological signs of experimental autoimmune encephalomyelitis

    Halina Offner;Bozena Celnik;Timothy S. Bringman;Denise Casentini-Borocz

  • GPR30 Contributes to Estrogen-Induced Thymic Atrophy

    Chunhe Wang;Babak Dehghani;Babak Dehghani;I. Jack Magrisso;I. Jack Magrisso;Elizabeth A. Rick

  • Functional assay for human CD4+CD25+ Treg cells reveals an age-dependent loss of suppressive activity.

    Laura Tsaknaridis;Leslie Spencer;Nicole Culbertson;Kevin Hicks

  • Treatment of multiple sclerosis with T-cell receptor peptides: results of a double-blind pilot trial.

    Arthur A. Vandenbark;Arthur A. Vandenbark;Yuan K. Chou;Ruth Whitham;Ruth Whitham;Michele Mass

  • Enhanced FoxP3 expression and Treg cell function in pregnant and estrogen-treated mice

    Magdalena J. Polanczyk;Magdalena J. Polanczyk;Corwyn Hopke;Jianya Huan;Arthur A. Vandenbark;Arthur A. Vandenbark

  • Effect of experimental stroke on peripheral immunity: CNS ischemia induces profound immunosuppression.

    H. Offner;A. A. Vandenbark;A. A. Vandenbark;Patricia D Hurn

Frequent Co-Authors

Arthur A. Vandenbark
Arthur A. Vandenbark Oregon Health & Science University
Cory Teuscher
Cory Teuscher University of Vermont
Adriana Weinberg
Adriana Weinberg University of Colorado Anschutz Medical Campus
Richard Bucala
Richard Bucala Yale University
Lars Fugger
Lars Fugger University of Oxford
Paco S. Herson
Paco S. Herson University of Colorado Denver
Gerald T. Nepom
Gerald T. Nepom Virginia Mason Medical Center
Owen J. T. McCarty
Owen J. T. McCarty Oregon Health & Science University
Raymond Pieters
Raymond Pieters Utrecht University
Yoram Reiter
Yoram Reiter Technion – Israel Institute of Technology

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