2026 Alex K. Shalek: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	83	3407	3136	1717	1541	370	60324

Research.com Recognitions

2018 - Fellow of Alfred P. Sloan Foundation

Overview

Alex K. Shalek is affiliated with MIT in the United States. Their research primarily spans the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology.

The main topics covered in their work include:

Single-cell and spatial transcriptomics
Immune Cell Function and Interaction
T-cell and B-cell Immunology
Cancer Genomics and Diagnostics
Immune cells in cancer
Tuberculosis Research and Epidemiology
Cancer Cells and Metastasis

Shalek has contributed to subfields such as Immunology, Molecular Biology, Oncology, Infectious Diseases, and Epidemiology.

Their publication record includes multiple papers in notable venues. Frequent publication venues are:

bioRxiv (Cold Spring Harbor Laboratory)
Cancer Research
Nature Communications
The Journal of Immunology
Cell

Selected recent papers by Alex K. Shalek include:

"Systematic comparison of single-cell and single-nucleus RNA-sequencing methods," 2020, Nature Biotechnology
"Prevention of tuberculosis in macaques after intravenous BCG immunization," 2020, Nature
"The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution," 2020, Cell
"Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer," 2021, Cell
"Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19," 2020, Immunity

Shalek frequently collaborates with other researchers, including:

José Ordovás-Montañés
Marc H. Wadsworth
Travis K. Hughes
Sarah K. Nyquist
Peter Winter

In 2018, Alex K. Shalek was named a Fellow of the Alfred P. Sloan Foundation.

Best Publications

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

Evan Z. Macosko;Evan Z. Macosko;Anindita Basu;Anindita Basu;Rahul Satija;Rahul Satija;James Nemesh;James Nemesh

7709
Citations
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Itay Tirosh;Benjamin Izar;Benjamin Izar;Sanjay M. Prakadan;Marc H. Wadsworth

5055
Citations
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

Anoop Premswaroop Patel;I. Tirosh;J. J. Trombetta;Alexander Kann Shalek

4475
Citations
MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data

Greg Finak;Andrew McDavid;Masanao Yajima;Jingyuan Deng

3326
Citations
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.

Carly G.K. Ziegler;Samuel J. Allon;Sarah K. Nyquist;Ian M. Mbano

2401
Citations
The Human Cell Atlas

Aviv Regev;Aviv Regev;Aviv Regev;Sarah A Teichmann;Sarah A Teichmann;Sarah A Teichmann;Eric S Lander;Eric S Lander;Eric S Lander;Ido Amit

1560
Citations
Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells

Alex K. Shalek;Rahul Satija;Xian Adiconis;Rona S. Gertner

1399
Citations
A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

Livnat Jerby-Arnon;Parin Shah;Michael S. Cuoco;Christopher Rodman

1386
Citations
Single-cell RNA-seq reveals dynamic paracrine control of cellular variation

Alex K. Shalek;Rahul Satija;Joe Shuga;John J. Trombetta

1292
Citations
SARS-CoV-2 Receptor ACE2 is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Enriched in Specific Cell Subsets Across Tissues

Carly Ziegler;Samuel J. Allon;Sarah K. Nyquist;Ian Mbano

1224
Citations
Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

Christopher S. Smillie;Moshe Biton;Jose Ordovas-Montanes;Keri M. Sullivan

1048
Citations
Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells

Mario Luca Suva;Mario Luca Suva;Mario Luca Suva;Esther Rheinbay;Esther Rheinbay;Esther Rheinbay;Shawn M. Gillespie;Shawn M. Gillespie;Shawn M. Gillespie;Anoop Premswaroop Patel;Anoop Premswaroop Patel

939
Citations
Systematic comparison of single-cell and single-nucleus RNA-sequencing methods.

Jiarui Ding;Xian Adiconis;Sean K. Simmons;Monika S. Kowalczyk

859
Citations
Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity.

Peter van Galen;Volker Hovestadt;Marc H. Wadsworth;Marc H. Wadsworth;Marc H. Wadsworth;Travis K. Hughes;Travis K. Hughes;Travis K. Hughes

819
Citations
Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput

Todd M Gierahn;Marc H Wadsworth;Marc H Wadsworth;Marc H Wadsworth;Travis K Hughes;Travis K Hughes;Travis K Hughes;Bryan D Bryson;Bryan D Bryson

803
Citations
Dynamic regulatory network controlling Th17 cell differentiation

Nir Yosef;Alex K. Shalek;Jellert T. Gaublomme;Hulin Jin

790
Citations
COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets.

Toni M. Delorey;Carly G. K. Ziegler;Graham Heimberg;Rachelly Normand

673
Citations
Vertical nanowire electrode arrays as a scalable platform for intracellular interfacing to neuronal circuits

Jacob T. Robinson;Marsela Jorgolli;Alex K. Shalek;Myung-Han Yoon

655
Citations
Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells

Mario L. Suvà;Esther Rheinbay;Shawn M. Gillespie;Anoop P. Patel

0
Citations
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

I. Tirosh;B. Izar;D. Treacy;J. J. Trombetta

0
Citations