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Immunology

D-Index
48
Citations
22249
World Ranking
4374
National Ranking
378

Overview

Alasdair Leslie is affiliated with University College London in the United Kingdom. Their research primarily focuses on the fields of Medicine and Immunology and Microbiology, contributing extensively to the subfields of Infectious Diseases, Immunology, Epidemiology, Molecular Biology, and Surgery.

The scientist has published prominently on topics including Tuberculosis Research and Epidemiology, SARS-CoV-2 and COVID-19 Research, COVID-19 Clinical Research Studies, Mycobacterium research and diagnosis, Immune Cell Function and Interaction, HIV Research and Treatment, and Pneumocystis jirovecii pneumonia detection and treatment.

Recent notable papers by Alasdair Leslie include:

  • SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues, 2020, Cell
  • Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization, 2021, Nature
  • Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control, 2022, Immunity
  • Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection, 2020, Nature Medicine
  • Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α, 2020, eLife

Alasdair Leslie frequently collaborates with a core group of co-authors, including:

  • Farina Karim
  • Henrik N. Kløverpris
  • Thumbi Ndung'u
  • Matilda Mazibuko
  • Adrie J. C. Steyn

The scientist's work has appeared in multiple publication venues with the most frequent being:

  • Frontiers in Immunology (11 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (7 publications)
  • eLife (3 publications)
  • SSRN Electronic Journal (3 publications)
  • JCI Insight (3 publications)

Best Publications

  • PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

    Cheryl L Day;Daniel E Kaufmann;Photini Kiepiela;Julia A Brown

  • SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.

    Carly G.K. Ziegler;Samuel J. Allon;Sarah K. Nyquist;Ian M. Mbano

  • Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

    Unknown

  • CD8+ T-cell responses to different HIV proteins have discordant associations with viral load

    Photini Kiepiela;Kholiswa Ngumbela;Christina Thobakgale;Dhanwanthie Ramduth

  • SARS-CoV-2 Receptor ACE2 is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Enriched in Specific Cell Subsets Across Tissues

    Carly Ziegler;Samuel J. Allon;Sarah K. Nyquist;Ian Mbano

  • HIV evolution: CTL escape mutation and reversion after transmission.

    A J Leslie;K J Pfafferott;P Chetty;R Draenert

  • Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.

    Photini Kiepiela;Alasdair J. Leslie;Isobella Honeyborne;Danni Ramduth

  • Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma.

    Sandile Cele;Inbal Gazy;Inbal Gazy;Laurelle Jackson;Shi-Hsia Hwa

  • Adaptation of HIV-1 to human leukocyte antigen class I

    Y. Kawashima;K. Pfafferott;J. Frater;P. Matthews

  • Fitness Cost of Escape Mutations in p24 Gag in Association with Control of Human Immunodeficiency Virus Type 1

    Javier Martinez-Picado;Julia G. Prado;Elizabeth E. Fry;Katja Pfafferott

  • Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency

    Yannick Simoni;Michael Fehlings;Henrik N. Kløverpris;Naomi McGovern

  • Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties.

    Eva Billerbeck;Yu Hoi Kang;Lucy Walker;Helen Lockstone

  • Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.

    Rika Draenert;Sylvie Le Gall;Katja J. Pfafferott;Alasdair J. Leslie

  • Structure and Interactions of the Human Programmed Cell Death 1 Receptor

    Xiaoxiao Cheng;Vaclav Veverka;Anand Radhakrishnan;Lorna C. Waters

  • Biological differences between the sexes and susceptibility to tuberculosis.

    Shepherd Nhamoyebonde;Alasdair Leslie

  • Immune escape precedes breakthrough human immunodeficiency virus type 1 viremia and broadening of the cytotoxic T-lymphocyte response in an HLA-B27-positive long-term-nonprogressing child.

    M. E. Feeney;Y. Tang;K. A. Roosevelt;A. J. Leslie

  • Compensatory Mutation Partially Restores Fitness and Delays Reversion of Escape Mutation within the Immunodominant HLA-B*5703-Restricted Gag Epitope in Chronic Human Immunodeficiency Virus Type 1 Infection

    Hayley Crawford;Julia G. Prado;Alasdair Leslie;Stéphane Hué

  • Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point

    Zaza M. Ndhlovu;Philomena Kamya;Philomena Kamya;Nikoshia Mewalal;Henrik N. Kløverpris

  • Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA

    Alasdair Leslie;Daniel Kavanagh;Isobella Honeyborne;Katja Pfafferott

  • The Intracellular Sensor NOD2 Induces MicroRNA-29 Expression in Human Dendritic Cells to Limit IL-23 Release

    Oliver Brain;Oliver Brain;Benjamin M.J. Owens;Tica Pichulik;Philip Allan;Philip Allan

  • Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703–positive individuals and their transmission recipients

    Hayley Crawford;Wendy Lumm;Alasdair Leslie;Malinda Schaefer

Frequent Co-Authors

Philip J. R. Goulder
Philip J. R. Goulder University of Oxford
Bruce D. Walker
Bruce D. Walker Harvard University
Thumbi Ndung'u
Thumbi Ndung'u University of KwaZulu-Natal
Christian Brander
Christian Brander University of Vic - Central University of Catalonia
Penny L. Moore
Penny L. Moore National Health Laboratory Service
James I. Mullins
James I. Mullins University of Washington
Søren Buus
Søren Buus University of Copenhagen
Paul Klenerman
Paul Klenerman University of Oxford
Philippa C. Matthews
Philippa C. Matthews University of Oxford

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