D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 101 Citations 42,870 186 World Ranking 659 National Ranking 424

Research.com Recognitions

Awards & Achievements

2008 - Distinguished Scientist Award, American Heart Association

1992 - Nobel Prize for their discoveries concerning reversible protein phosphorylation as a biological regulatory mechanism

1991 - Welch Award in Chemistry, Robert A. Welch Foundation

1989 - Albert Lasker Award for Basic Medical Research, Lasker Foundation

1978 - Canada Gairdner International Award

1973 - Member of the National Academy of Sciences

1966 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • Amino acid

Biochemistry, Protein kinase A, Molecular biology, Kinase and Cell biology are his primary areas of study. His study in Phosphorylase kinase, Glycogen phosphorylase, Mitogen-activated protein kinase kinase, Enzyme and Threonine is done as part of Biochemistry. His research in Phosphorylase kinase intersects with topics in Adenosine triphosphate and Skeletal muscle.

His Protein kinase A research is multidisciplinary, incorporating elements of Protein structure, Glycogen synthase and Adenosine. His Molecular biology study integrates concerns from other disciplines, such as Casein kinase 2, cDNA library, Peptide sequence, Phosphorylation and Serine/threonine-specific protein kinase. In his study, Isozyme is strongly linked to Protein subunit, which falls under the umbrella field of Kinase.

His most cited work include:

  • The MAPK signaling cascade. (3161 citations)
  • Protein Serine/Threonine Kinases (1221 citations)
  • An Adenosine 3',5'-Monophosphate-dependant Protein Kinase from Rabbit Skeletal Muscle (1220 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of investigation include Biochemistry, Protein kinase A, Molecular biology, Cell biology and Kinase. His biological study deals with issues like Skeletal muscle, which deal with fields such as Phosphorylase b and Adenosine triphosphate. His Protein kinase A research integrates issues from Threonine, Protein subunit and GSK-3.

His Molecular biology study also includes

  • Phosphatase most often made with reference to Protein tyrosine phosphatase,
  • Fibroblast growth factor which intersects with area such as Xenopus. His Phosphorylase kinase research incorporates elements of Calcium and Adenine nucleotide. Edwin G. Krebs combines subjects such as MAP kinase kinase kinase and MAP2K7 with his study of Mitogen-activated protein kinase kinase.

He most often published in these fields:

  • Biochemistry (63.51%)
  • Protein kinase A (37.91%)
  • Molecular biology (36.02%)

What were the highlights of his more recent work (between 1994-2016)?

  • Cell biology (24.64%)
  • Protein kinase A (37.91%)
  • Molecular biology (36.02%)

In recent papers he was focusing on the following fields of study:

His main research concerns Cell biology, Protein kinase A, Molecular biology, MAPK/ERK pathway and Biochemistry. In his study, Actin, Chemotaxis and Colforsin is inextricably linked to Platelet-derived growth factor receptor, which falls within the broad field of Cell biology. To a larger extent, Edwin G. Krebs studies Kinase with the aim of understanding Protein kinase A.

His Molecular biology study combines topics from a wide range of disciplines, such as Epidermal growth factor, Kinase activity, Protein tyrosine phosphatase, Phosphorylation and Fibroblast growth factor. His MAPK/ERK pathway research focuses on Apoptosis and how it relates to B-cell receptor. Edwin G. Krebs works mostly in the field of Biochemistry, limiting it down to concerns involving Insulin Receptor Substrate Proteins and, occasionally, IRS2 and Insulin receptor substrate.

Between 1994 and 2016, his most popular works were:

  • The MAPK signaling cascade. (3161 citations)
  • Rapid Membrane Effects of Steroids in Neuroblastoma Cells: Effects of Estrogen on Mitogen Activated Protein Kinase Signalling Cascade and c-fos Immediate Early Gene Transcription (459 citations)
  • Selective requirement for MAP kinase activation in thymocyte differentiation. (369 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • Amino acid

Edwin G. Krebs focuses on Cell biology, Protein kinase A, MAPK/ERK pathway, Molecular biology and Signal transduction. Edwin G. Krebs interconnects B-cell receptor and Platelet-derived growth factor receptor in the investigation of issues within Cell biology. His Protein kinase A research includes themes of Eukaryotic Initiation Factor-4E, GSK-3, Forskolin, Platelet-derived growth factor and Type 2 diabetes.

His work carried out in the field of Molecular biology brings together such families of science as Cyclin-dependent kinase 4, Cyclin-dependent kinase 2, Mitogen-activated protein kinase kinase, CDC2 Protein Kinase and Phosphorylation. Phosphorylation is a subfield of Biochemistry that Edwin G. Krebs explores. His Signal transduction research includes elements of Endocrinology and Insulin receptor.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

The MAPK signaling cascade.

Rony Seger;Edwin G. Krebs.
The FASEB Journal (1995)

4455 Citations

An Adenosine 3',5'-Monophosphate-dependant Protein Kinase from Rabbit Skeletal Muscle

D. A. Walsh;John P. Perkins;Edwin G. Krebs.
Journal of Biological Chemistry (1968)

1993 Citations

Protein Serine/Threonine Kinases

Arthur M. Edelman;Donald K. Blumenthal;Edwin G. Krebs.
Annual Review of Biochemistry (1987)

1743 Citations

Purification and Characterization of a Protein Inhibitor of Adenosine 3',5'-Monophosphate-dependent Protein Kinases

Donal A. Walsh;Charles D. Ashby;Carmen Gonzalez;Dianne Calkins.
Journal of Biological Chemistry (1971)

1220 Citations

Purification and properties of rabbit skeletal muscle adenosine 3',5'-monophosphate-dependent protein kinases.

Erwin M. Reimann;Donal A. Walsh;Edwin G. Krebs.
Journal of Biological Chemistry (1971)

1126 Citations

Role of multiple basic residues in determining the substrate specificity of cyclic AMP-dependent protein kinase.

B E Kemp;D J Graves;E Benjamini;E G Krebs.
Journal of Biological Chemistry (1977)

972 Citations

The isolation and crystallization of rabbit skeletal muscle phosphorylase b.

Edmond H. Fischer;Edwin G. Krebs.
Journal of Biological Chemistry (1958)

899 Citations

PURIFICATION AND PROPERTIES OF RABBIT SKELETAL MUSCLE PHOSPHORYLASE B KINASE.

Edwin G. Krebs;David S. Love;Gloria E. Bratvold;Kenneth A. Trayser.
Biochemistry (1964)

735 Citations

[43] Preparation of homogeneous cyclic AMP-dependent protein kinase(s) and its subunits from rabbit skeletal muscle

J.A. Beavo;P.J. Bechtel;E.G. Krebs.
Methods in Enzymology (1974)

690 Citations

Rapid Membrane Effects of Steroids in Neuroblastoma Cells: Effects of Estrogen on Mitogen Activated Protein Kinase Signalling Cascade and c-fos Immediate Early Gene Transcription

Jyoti J. Watters;Jean S. Campbell;Matthew J. Cunningham;Edwin G. Krebs.
Endocrinology (1997)

609 Citations

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