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Biology and Biochemistry

D-Index
72
Citations
14293
World Ranking
6458
National Ranking
233

Overview

David W. Litchfield is affiliated with the University of Western Ontario in Canada. Their research primarily concentrates on biochemistry, genetics, and molecular biology, with a specific focus on molecular biology and oncology.

The main research topics covered by David W. Litchfield include:

  • Protein Kinase Regulation and GTPase Signaling
  • Enzyme Structure and Function
  • Cancer-related Molecular Pathways
  • Protein Tyrosine Phosphatases
  • Connexins and lens biology
  • Heat shock proteins research
  • Biochemical and Molecular Research

David W. Litchfield has published extensively in several scientific journals. The frequent publication venues are:

  • UNC Libraries
  • Biomedicines
  • Cell chemical biology
  • Nature Chemical Biology
  • British Journal of Cancer

Some selected recent publications include:

  • "Development of a potent and selective chemical probe for the pleiotropic kinase CK2", 2021, Cell chemical biology
  • "CK2 Regulation: Perspectives in 2021", 2021, Biomedicines
  • "Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors", 2023, Nature Chemical Biology
  • "CSNK2 in cancer: pathophysiology and translational applications", 2021, British Journal of Cancer
  • "Pannexin 1 mutation found in melanoma tumor reduces phosphorylation, glycosylation, and trafficking of the channel-forming protein", 2021, Molecular Biology of the Cell

Frequent co-authors working with David W. Litchfield include:

  • Laszlo Gyenis
  • Daniel Menyhart
  • Scott E. Roffey
  • Kristina Jurčić
  • Susanne Müller

Best Publications

  • Protein kinase CK2: structure, regulation and role in cellular decisions of life and death.

    David W. Litchfield

  • Premature p34cdc2 activation required for apoptosis

    Lianfa Shi;W. K. Nishioka;J. Th'ng;E. M. Bradbury

  • Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation

    Bernhard Lüscher;Erik Christenson;David W. Litchfield;Edwin G. Krebs

  • Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation.

    Henning Kleine;Elzbieta Poreba;Krzysztof Lesniewicz;Paul O. Hassa

  • Too much of a good thing: the role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2.

    James S. Duncan;David W. Litchfield

  • Solution structure of the tetrameric minimum transforming domain of p53

    Weontae Lee;Timothy S. Harvey;Timothy S. Harvey;Ya Yin;Patrick Yau

  • EGF-Induced ERK Activation Promotes CK2-Mediated Disassociation of α-Catenin from β-Catenin and Transactivation of β-Catenin

    Haitao Ji;Ji Wang;Heinz Nika;David Hawke

  • Casein kinase II in signal transduction and cell cycle regulation.

    David W. Litchfield;Bernard Lüscher

  • Isolation and characterization of human cDNA clones encoding the .alpha. and the .alpha.' subunits of casein kinase II

    Fred J. Lozeman;David W. Litchfield;Carol Piening;Koji Takio

  • Okadaic acid mimics the action of insulin in stimulating protein kinase activity in isolated adipocytes. The role of protein phosphatase 2a in attenuation of the signal.

    T. A. J. Haystead;J. E. Weiel;D. W. Litchfield;Y. Tsukitani

  • Order or chaos? An evaluation of the regulation of protein kinase CK2.

    Mary Ellen K Olsten;David W Litchfield

  • Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder.

    Yangyang Bian;Yangyang Bian;Lei Li;Lei Li;Mingming Dong;Mingming Dong;Xuguang Liu

  • Phosphorylation of the beta subunit of casein kinase II in human A431 cells. Identification of the autophosphorylation site and a site phosphorylated by p34cdc2.

    D.W. Litchfield;F.J. Lozeman;M.F. Cicirelli;M. Harrylock

  • Phosphorylation of casein kinase II by p34cdc2 in vitro and at mitosis.

    D W Litchfield;B Lüscher;F J Lozeman;R N Eisenman

  • Tra1p Is a Component of the Yeast Ada·Spt Transcriptional Regulatory Complexes

    Ayman Saleh;David Schieltz;Nicholas Ting;Steven B. McMahon

  • Casein Kinase II as a Potentially Important Enzyme Concerned with Signal Transduction

    E G Krebs;R N Eisenman;E A Kuenzel;D W Litchfield

  • Enzymatic Site‐Specific Functionalization of Protein Methyltransferase Substrates with Alkynes for Click Labeling

    Wibke Peters;Sophie Willnow;Mike Duisken;Henning Kleine

  • Interactions between the Subunits of Casein Kinase II

    R. Daniel Gietz;Kevin C. Graham;David W. Litchfield

  • Identification and Characterization of CKIP-1, a Novel Pleckstrin Homology Domain-containing Protein That Interacts with Protein Kinase CK2 *

    Denis G. Bosc;Kevin C. Graham;Ronald B. Saulnier;Cunjie Zhang

  • Interactions between Protein Kinase CK2 and Pin1 EVIDENCE FOR PHOSPHORYLATION-DEPENDENT INTERACTIONS

    Moira M. Messenger;Ronald B. Saulnier;Andrew D. Gilchrist;Phaedra Diamond

Frequent Co-Authors

Bernhard Lüscher
Bernhard Lüscher RWTH Aachen University
Shawn S.-C. Li
Shawn S.-C. Li University of Western Ontario
Lee M. Graves
Lee M. Graves University of North Carolina at Chapel Hill
Edwin G. Krebs
Edwin G. Krebs University of Washington
Gregory B. Gloor
Gregory B. Gloor University of Western Ontario
Gilles A. Lajoie
Gilles A. Lajoie University of Western Ontario
Dale W. Laird
Dale W. Laird University of Western Ontario
Arnold H. Greenberg
Arnold H. Greenberg University of Manitoba
Timothy A. J. Haystead
Timothy A. J. Haystead Duke University
Stefan Knapp
Stefan Knapp Goethe University Frankfurt

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