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D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
10032
World Ranking
16663
National Ranking
585

Overview

Shawn S.-C. Li is affiliated with the University of Western Ontario in Canada. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine, focusing notably on oncology, infectious diseases, pulmonary and respiratory medicine, and immunology.

Their principal fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Subfields of specialty cover:

  • Molecular Biology
  • Oncology
  • Infectious Diseases
  • Pulmonary and Respiratory Medicine
  • Immunology

Main research topics addressed by Shawn S.-C. Li involve:

  • PI3K/AKT/mTOR signaling in cancer
  • Epigenetics and DNA Methylation
  • Pancreatic and Hepatic Oncology Research
  • Cancer Immunotherapy and Biomarkers
  • RNA modifications and cancer
  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies

The scientist has published recent papers including the following:

  • The spatial transcriptomic landscape of non-small cell lung cancer brain metastasis, 2022, Nature Communications
  • The intrinsic substrate specificity of the human tyrosine kinome, 2024, Nature
  • Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern, 2021, JCI Insight
  • Phosphorylation-dependent substrate selectivity of protein kinase B (AKT1), 2020, Journal of Biological Chemistry
  • Phospho-Form Specific Substrates of Protein Kinase B (AKT1), 2021, Frontiers in Bioengineering and Biotechnology

Frequent publication venues where Shawn S.-C. Li's work appears are:

  • Nature Communications
  • Journal of Biological Chemistry
  • Analytical Chemistry
  • Clinical Proteomics
  • Cancers

They have collaborated frequently with several co-authors, including:

  • Rober Abdo
  • Tomonori Kaneko
  • Courtney Voss
  • Owen Hovey
  • Xuguang Liu

Best Publications

  • Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes

    Nina Jones;Ivan M. Blasutig;Ivan M. Blasutig;Vera Eremina;Vera Eremina;Julie M. Ruston

  • Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transduction.

    Shawn S.-C. Li

  • Linear Motif Atlas for Phosphorylation-Dependent Signaling

    Martin Lee Miller;Martin Lee Miller;Lars Juhl Jensen;Francesca Diella;Claus Jørgensen

  • Non-histone protein methylation as a regulator of cellular signalling and function

    Kyle K. Biggar;Shawn S.-C. Li

  • CIS is a potent checkpoint in NK cell–mediated tumor immunity

    Rebecca B. Delconte;Tatiana B Kolesnik;Laura F. Dagley;Laura F. Dagley;Jai Rautela;Jai Rautela

  • Defining the Specificity Space of the Human Src Homology 2 Domain

    Haiming Huang;Lei Li;Chenggang Wu;David Schibli

  • Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)

    Chao Xu;Chuanbing Bian;Wei Yang;Marek Galka

  • Coexistence of EGFR with KRAS , or BRAF , or PIK3CA somatic mutations in lung cancer: a comprehensive mutation profiling from 5125 Chinese cohorts

    S Li;L Li;Y Zhu;C Huang

  • Seneca Valley virus, a systemically deliverable oncolytic picornavirus, and the treatment of neuroendocrine cancers.

    P. Seshidhar Reddy;Kevin D. Burroughs;Laura M. Hales;Shanthi Ganesh

  • Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder.

    Yangyang Bian;Yangyang Bian;Lei Li;Lei Li;Mingming Dong;Mingming Dong;Xuguang Liu

  • Molecular Characterization of Propionyllysines in Non-histone Proteins

    Zhongyi Cheng;Yi Tang;Yue Chen;Sungchan Kim

  • Structural basis for specific binding of the Gads SH3 domain to an RxxK motif-containing SLP-76 peptide: a novel mode of peptide recognition.

    Qin Liu;Donna Berry;Piers Nash;Tony Pawson;Tony Pawson

  • MicroRNA-145 inhibits the growth, invasion, metastasis and angiogenesis of neuroblastoma cells through targeting hypoxia-inducible factor 2 alpha

    H Zhang;J Pu;T Qi;M Qi

  • Structure of the ubiquitin‐binding zinc finger domain of human DNA Y‐polymerase η

    Martha G Bomar;Ming‐Tao Pai;Shiou‐Ru Tzeng;Shawn Shun‐Cheng Li

  • Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes

    Ylva Ivarsson;Roland Arnold;Megan McLaughlin;Satra Nim

  • Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

    Rajesh Ghai;Andrea Bugarcic;Huadong Liu;Suzanne J. Norwood

  • Loops Govern SH2 Domain Specificity by Controlling Access to Binding Pockets

    Tomonori Kaneko;Haiming Huang;Bing Zhao;Lei Li

  • Superbinder SH2 Domains Act as Antagonists of Cell Signaling

    Tomonori Kaneko;Haiming Huang;Xuan Cao;Xing Li

  • Numb regulates cell-cell adhesion and polarity in response to tyrosine kinase signalling.

    Zezhou Wang;Shelley Sandiford;Chenggang Wu;Shawn Shun-Cheng Li

  • Phosphorylated YDXV Motifs and Nck SH2/SH3 Adaptors Act Cooperatively To Induce Actin Reorganization

    Ivan M. Blasutig;Laura A. New;Ajitha Thanabalasuriar;Thamara K. Dayarathna

Frequent Co-Authors

Tony Pawson
Tony Pawson University of Toronto
Sachdev S. Sidhu
Sachdev S. Sidhu University of Waterloo
David W. Litchfield
David W. Litchfield University of Western Ontario
Susan E. Quaggin
Susan E. Quaggin Northwestern University
Thomas Jansson
Thomas Jansson The University of Texas Health Science Center at San Antonio
Sandra E. Nicholson
Sandra E. Nicholson Walter and Eliza Hall Institute of Medical Research
Stefan Knapp
Stefan Knapp Goethe University Frankfurt
Gilles A. Lajoie
Gilles A. Lajoie University of Western Ontario
Cheryl H. Arrowsmith
Cheryl H. Arrowsmith Structural Genomics Consortium
Rakesh K. Joshi
Rakesh K. Joshi University of New South Wales

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