World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
103
Citations
45903
World Ranking
1096
National Ranking
439

Biology and Biochemistry

D-Index
115
Citations
59967
World Ranking
776
National Ranking
488

Research.com Recognitions

  • 2010 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2010 - National Institutes of Health Director's Pioneer Award

Overview

Stephen W. Fesik is affiliated with Vanderbilt University in the United States and has contributed extensively to research in biochemistry, genetics, and molecular biology, with significant work also in medicine. Their research spans several established subfields, including molecular biology, oncology, organic chemistry, materials chemistry, and hematology.

The scientist's main topics of work include:

  • Protein Degradation and Inhibitors
  • Cancer-related gene regulation
  • Peptidase Inhibition and Analysis
  • Genomics and Chromatin Dynamics
  • Ubiquitin and proteasome pathways
  • Click Chemistry and Applications
  • Protein Kinase Regulation and GTPase Signaling

Frequent co-authors in their publications are:

  • William P. Tansey
  • Taekyu Lee
  • Alex G. Waterson
  • John Sensintaffar
  • Shelly L. Lorey

Fesik has published predominantly in the following venues:

  • Journal of Medicinal Chemistry
  • Proceedings of the National Academy of Sciences
  • eLife
  • ACS Medicinal Chemistry Letters
  • Cancer Research

Selected recent papers include:

  • WDR5 is a conserved regulator of protein synthesis gene expression, 2020, Nucleic Acids Research
  • Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS G12C Inhibitor, 2022, Journal of Medicinal Chemistry
  • Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design, 2020, Journal of Medicinal Chemistry
  • Impact of WIN site inhibitor on the WDR5 interactome, 2021, Cell Reports
  • WIN site inhibition disrupts a subset of WDR5 function, 2022, Scientific Reports

Throughout their career, Stephen W. Fesik has received recognitions such as the National Institutes of Health Director's Pioneer Award and becoming a Fellow of the American Association for the Advancement of Science in 2010.

Best Publications

  • An inhibitor of Bcl-2 family proteins induces regression of solid tumours

    Tilman Oltersdorf;Steven W. Elmore;Alexander R. Shoemaker;Robert C. Armstrong

  • Discovering High-Affinity Ligands for Proteins: SAR by NMR

    Suzanne B. Shuker;Philip J. Hajduk;Robert P. Meadows;Stephen W. Fesik

  • ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

    Christin Tse;Alexander R. Shoemaker;Jessica Adickes;Mark G. Anderson

  • Drugging the undruggable Ras: mission possible?

    Adrienne D. Cox;Stephen W. Fesik;Alec C. Kimmelman;Ji Luo

  • X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death.

    Steven W. Muchmore;Michael Sattler;Heng Liang;Robert P. Meadows

  • Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis.

    Michael Sattler;Heng Liang;David Nettesheim;Robert P. Meadows

  • Promoting apoptosis as a strategy for cancer drug discovery

    Stephen W. Fesik

  • Bcl-x(L) forms an ion channel in synthetic lipid membranes.

    Andy J. Minn;Patricio Vélez;Sharon L. Schendel;Heng Liang

  • Structural Basis for the Inhibition of Caspase-3 by XIAP

    Stefan J. Riedl;Martin Renatus;Robert Schwarzenbacher;Qiao Zhou

  • Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate.

    John E. Harlan;Philip J. Hajduk;Ho Sup Yoon;Stephen W. Fesik

  • Structural biology of the Bcl-2 family of proteins.

    Andrew M. Petros;Edward T. Olejniczak;Stephen W. Fesik

  • Twenty years on: the impact of fragments on drug discovery.

    Daniel A. Erlanson;Stephen W. Fesik;Roderick E. Hubbard;Wolfgang Jahnke

  • 14-3-3 Proteins and Survival Kinases Cooperate to Inactivate BAD by BH3 Domain Phosphorylation

    Sandeep Robert Datta;Alex Katsov;Linda Hu;Andrew Petros

  • Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

    Zhihong Liu;Chaohong Sun;Edward T. Olejniczak;Robert P. Meadows

  • Specificity of short interfering RNA determined through gene expression signatures

    Dimitri Semizarov;Leigh Frost;Aparna Sarthy;Paul Kroeger

  • Druggability indices for protein targets derived from NMR-based screening data.

    Philip J. Hajduk;and Jeffrey R. Huth;Stephen W. Fesik

  • MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation

    Kyung min Lee;Jennifer M. Giltnane;Justin M. Balko;Luis J. Schwarz

  • Solution structure of the antiapoptotic protein bcl-2.

    Andrew M. Petros;Ales Medek;David G. Nettesheim;Daniel H. Kim

  • Heteronuclear three-dimensional nmr spectroscopy. A strategy for the simplification of homonuclear two-dimensional NMR spectra

    Stephen W Fesik;Erik R.P Zuiderweg

  • Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.

    Qi Sun;Jason P. Burke;Jason Phan;Michael C. Burns

Frequent Co-Authors

Edward T. Olejniczak
Edward T. Olejniczak Vanderbilt University
Philip J. Hajduk
Philip J. Hajduk National Institutes of Health
Saul H. Rosenberg
Saul H. Rosenberg AbbVie (United States)
Craig B. Thompson
Craig B. Thompson Memorial Sloan Kettering Cancer Center
Walter J. Chazin
Walter J. Chazin Vanderbilt University
Alexandros Makriyannis
Alexandros Makriyannis Northeastern University
Ming-Ming Zhou
Ming-Ming Zhou Icahn School of Medicine at Mount Sinai
Shaun R. Stauffer
Shaun R. Stauffer Cleveland Clinic
Kennan C. Marsh
Kennan C. Marsh AbbVie (United States)
Jun Chen
Jun Chen Nankai University

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