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Edward T. Olejniczak

Edward T. Olejniczak

D-Index & Metrics

Chemistry

D-Index
66
Citations
15569
World Ranking
7276
National Ranking
2157

Overview

Edward T. Olejniczak is affiliated with Vanderbilt University in the United States. Their research primarily focuses on fields within Biochemistry, Genetics, and Molecular Biology, with specific attention to molecular biology, organic chemistry, oncology, materials chemistry, and hematology.

Olejniczak's work covers main topics such as:

  • Ubiquitin and proteasome pathways
  • Protein degradation and inhibitors
  • Click chemistry and applications
  • Cell death mechanisms and regulation
  • Peptidase inhibition and analysis
  • Cancer-related gene regulation
  • Genomics and chromatin dynamics

Their recent publications include:

  • "Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design," 2020, Journal of Medicinal Chemistry
  • "Impact of WIN site inhibitor on the WDR5 interactome," 2021, Cell Reports
  • "Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods," 2020, Journal of Medicinal Chemistry
  • "Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors," 2024, Journal of Medicinal Chemistry
  • "Structural Elucidation of Peptide Binding to KLHL-12, a Substrate Specific Adapter Protein in a Cul3-Ring E3 Ligase Complex," 2020, Biochemistry

Frequent coauthors collaborating with Olejniczak include:

  • Stephen W. Fesik
  • Bin Zhao
  • William G. Payne
  • Allison L. Arnold
  • John Sensintaffar

Their publications commonly appear in these venues:

  • Journal of Medicinal Chemistry
  • Cell Reports
  • Biochemistry
  • The Cambridge Structural Database
  • RSC Chemical Biology

Edward T. Olejniczak's body of work contributes to understanding molecular mechanisms underlying protein interactions, signaling, and regulation related to various biochemical pathways, including those implicated in cancer and hematological conditions.

Best Publications

  • Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

    Zhihong Liu;Chaohong Sun;Edward T. Olejniczak;Robert P. Meadows

  • Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation.

    Qi Sun;Jason P. Burke;Jason Phan;Michael C. Burns

  • Rationale for Bcl-XL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

    Andrew M. Petros;David G. Nettesheim;Yi Wang;Edward T. Olejniczak

  • NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain.

    Baohua Huang;Matthias Eberstadt;Edward T. Olejniczak;Robert P. Meadows

  • Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties.

    Gang Liu;Jeffrey R. Huth;Edward T. Olejniczak;Renaldo Mendoza

  • Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.

    Thorsten K Oost;Chaohong Sun;Robert C Armstrong;Ali-Samer Al-Assaad

  • Discovery of Potent Nonpeptide Inhibitors of Stromelysin Using SAR by NMR

    P. J. Hajduk;G. Sheppard;D. G. Nettesheim;E. T. Olejniczak

  • Structure and ligand recognition of the phosphotyrosine binding domain of Shc.

    Ming-Ming Zhou;Kodimangalam S. Ravichandran;Edward T. Olejniczak;Andrew M. Petros

  • Structural Characterization of a Soluble Amyloid β-Peptide Oligomer

    Liping Yu;Rohinton Edalji;John E. Harlan;Thomas F. Holzman

  • Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC

    L.R. Thomas;Q. Wang;B.C. Grieb;J. Phan

  • Analysis of deuterium nuclear magnetic resonance line shapes in anisotropic media

    R. J. Wittebort;E. T. Olejniczak;R. G. Griffin

  • A general method for assigning NMR spectra of denatured proteins using 3D HC(CO)NH-TOCSY triple resonance experiments.

    Timothy M. Logan;Edward T. Olejniczak;Robert X. Xu;Stephen W. Fesik

  • Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design

    Anders Friberg;Dominico Vigil;Bin Zhao;R. Nathan Daniels

  • Structure of the N-terminal RNA-binding domain of the SARS CoV nucleocapsid protein.

    Qiulong Huang;Liping Yu;Andrew M Petros;Angelo Gunasekera

  • Solution structure of a pleckstrin-homology domain.

    Ho Sup Yoon;Philip J. Hajduk;Andrew M. Petros;Edward T. Olejniczak

  • ALARM NMR: a rapid and robust experimental method to detect reactive false positives in biochemical screens.

    Jeffrey R Huth;Renaldo Mendoza;Edward T Olejniczak;Robert W Johnson

  • NMR Studies of [U-13C]Cyclosporin a Bound to Cyclophilin: Bound Conformation and Portions of Cyclosporin Involved in Binding.

    Fesik Sw;Gampe Rt;Eaton Hl;Gemmecker G

  • NMR Structure and Mutagenesis of the N-Terminal Dbl Homology Domain of the Nucleotide Exchange Factor Trio

    Xiaohong Liu;Hong Wang;Matthias Eberstadt;Arndt Schnuchel

  • Aminopyridine-Based c-Jun N-Terminal Kinase Inhibitors with Cellular Activity and Minimal Cross-Kinase Activity†

    Bruce G Szczepankiewicz;Christi Kosogof;Lissa T J Nelson;Gang Liu

  • 2D and 3D NMR spectroscopy employing carbon-13/carbon-13 magnetization transfer by isotropic mixing. Spin system identification in large proteins

    Stephen W. Fesik;Hugh L. Eaton;Edward T. Olejniczak;Erik R. P. Zuiderweg

  • Solution structure of the cyclosporin A/cyclophilin complex by NMR

    Yves Thériault;Timothy M. Logan;Robert Meadows;Liping Yu

Frequent Co-Authors

Stephen W. Fesik
Stephen W. Fesik Vanderbilt University
Philip J. Hajduk
Philip J. Hajduk National Institutes of Health
Walter J. Chazin
Walter J. Chazin Vanderbilt University
Daniel P. Raleigh
Daniel P. Raleigh Stony Brook University
Shimon Vega
Shimon Vega Weizmann Institute of Science
Shaun R. Stauffer
Shaun R. Stauffer Cleveland Clinic
Ming-Ming Zhou
Ming-Ming Zhou Icahn School of Medicine at Mount Sinai
Donald E. Staunton
Donald E. Staunton CisThera (United States)
Craig B. Thompson
Craig B. Thompson Memorial Sloan Kettering Cancer Center

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