D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 60 Citations 11,349 346 World Ranking 7963 National Ranking 198

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • Organic chemistry

Apoptosis, Gambogic acid, Cancer research, Wogonin and Cell biology are his primary areas of study. His Apoptosis study is concerned with the larger field of Biochemistry. The concepts of his Gambogic acid study are interwoven with issues in Garcinia, Cyclin-dependent kinase 1, Molecular biology, Growth inhibition and Phosphorylation.

His Molecular biology study integrates concerns from other disciplines, such as Angiogenesis, Telomerase, Telomerase reverse transcriptase, MTT assay and DNA fragmentation. His Cancer research research is multidisciplinary, incorporating elements of Cell growth, Immunology, Matrix metalloproteinase, Metastasis and MAPK/ERK pathway. His Cell biology study combines topics in areas such as Cell cycle checkpoint, Integrin, Ubiquitin and Immunoprecipitation.

His most cited work include:

  • The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update. (257 citations)
  • Endostar, a novel recombinant human endostatin, exerts antiangiogenic effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells. (162 citations)
  • ISOLATION AND CHARACTERIZATION OF CANCER STEM LIKE CELLS IN HUMAN GLIOBLASTOMA CELL LINES (152 citations)

What are the main themes of his work throughout his whole career to date?

Qidong You mainly investigates Biochemistry, Stereochemistry, Pharmacology, Combinatorial chemistry and Cancer research. His work in In vitro, Apoptosis, Gambogic acid, Enzyme and Protein–protein interaction is related to Biochemistry. His Apoptosis research incorporates elements of Molecular biology and Cell biology.

Qidong You undertakes multidisciplinary investigations into Pharmacology and Wogonin in his work. His research in Combinatorial chemistry intersects with topics in Pharmacophore, Virtual screening and Organic chemistry. His Cancer research research is multidisciplinary, incorporating perspectives in Cancer cell and Signal transduction, Kinase, MAPK/ERK pathway.

He most often published in these fields:

  • Biochemistry (21.46%)
  • Stereochemistry (20.20%)
  • Pharmacology (19.70%)

What were the highlights of his more recent work (between 2017-2021)?

  • Pharmacology (19.70%)
  • Cell biology (9.34%)
  • Protein–protein interaction (5.56%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in Pharmacology, Cell biology, Protein–protein interaction, Cancer research and Small molecule. His Pharmacology research incorporates themes from Oxidative stress, IC50, Rheumatoid arthritis and Drug discovery. His Cell biology research includes themes of Heat shock protein, CDC37 and Hsp90.

His Protein–protein interaction study is concerned with the field of Biochemistry as a whole. The study of Biochemistry is intertwined with the study of Reagent in a number of ways. His Cancer research research is multidisciplinary, incorporating perspectives in Cancer, Cancer therapy, Apoptosis, Tamoxifen and Signal transduction.

Between 2017 and 2021, his most popular works were:

  • Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway. (72 citations)
  • CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation. (34 citations)
  • Discovery of a head-to-tail cyclic peptide as the Keap1-Nrf2 protein-protein interaction inhibitor with high cell potency (29 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • Organic chemistry

His main research concerns Cancer research, Protein–protein interaction, Pharmacology, Cancer and Hsp90. He combines subjects such as Docking, Leukemia, HL60, Tamoxifen and PI3K/AKT/mTOR pathway with his study of Cancer research. Qidong You is investigating Biochemistry and Cell biology as part of his examination of Protein–protein interaction.

His Biochemistry research incorporates elements of Metal and Metal binding. He has included themes like Oxidative stress, Structure–activity relationship, Antioxidant and MPTP in his Pharmacology study. Qidong You interconnects Cell cycle checkpoint, Computational biology, Chaperone and Cell growth in the investigation of issues within Hsp90.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update.

Meng-Chen Lu;Jian-Ai Ji;Zheng-Yu Jiang;Qi-Dong You.
Medicinal Research Reviews (2016)

383 Citations

Endostar, a novel recombinant human endostatin, exerts antiangiogenic effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells.

Yun Ling;Yong Yang;Na Lu;Qi-dong You.
Biochemical and Biophysical Research Communications (2007)

245 Citations

Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells.

Jun Yu;Qing-Long Guo;Qi-Dong You;Li Zhao.
Carcinogenesis (2006)

229 Citations

ISOLATION AND CHARACTERIZATION OF CANCER STEM LIKE CELLS IN HUMAN GLIOBLASTOMA CELL LINES

Lei Qiang;Yong Yang;Yan-Jun Ma;Fei-Hong Chen.
Cancer Letters (2009)

229 Citations

Gambogic acid inhibits proliferation of human lung carcinoma SPC-A1 cells in vivo and in vitro and represses telomerase activity and telomerase reverse transcriptase mRNA expression in the cells.

Zhao-Qiu Wu;Qing-Long Guo;Qi-Dong You;Li Zhao.
Biological & Pharmaceutical Bulletin (2004)

224 Citations

Anti-hepatitis B virus activity of wogonin in vitro and in vivo.

Qinglong Guo;Li Zhao;Qidong You;Yong Yang.
Antiviral Research (2007)

194 Citations

Flavonoid baicalein suppresses adhesion, migration and invasion of MDA-MB-231 human breast cancer cells

Ling Wang;Yun Ling;Yan Chen;Cheng-Ling Li.
Cancer Letters (2010)

189 Citations

Chiral Drugs: Chemistry and Biological Action

Guo-Qiang Lin;Qi-Dong You;Jie-Fei Cheng.
(2011)

182 Citations

Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis.

Zheng-Yu Jiang;Meng-Chen Lu;Li Li Xu;Ting-Ting Yang.
Journal of Medicinal Chemistry (2014)

181 Citations

Differential apoptotic induction of gambogic acid, a novel anticancer natural product, on hepatoma cells and normal hepatocytes.

Yong Yang;Lan Yang;Qi-Dong You;Fei-Fei Nie.
Cancer Letters (2007)

172 Citations

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