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Biology and Biochemistry

D-Index
81
Citations
18457
World Ranking
3962
National Ranking
1952

Overview

Gerard A. Lutty is affiliated with Johns Hopkins University School of Medicine in the United States and focuses primarily on the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their research spans several intersecting subfields, including Ophthalmology, Molecular Biology, Radiology, Nuclear Medicine and Imaging, Cell Biology, and Immunology.

The main areas of study for Lutty's work concern retinal health and disease mechanisms. Their research topics encompass:

  • Retinal Diseases and Treatments
  • Retinal Development and Disorders
  • Retinal Imaging and Analysis
  • Retinal and Optic Conditions
  • Glaucoma and retinal disorders
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Connexins and lens biology

Lutty has contributed scholarly articles to a number of scientific journals, with frequent publications in venues such as Experimental Eye Research, Communications Biology, Investigative Ophthalmology & Visual Science, Progress in Retinal and Eye Research, and The Journal of Experimental Medicine. The distribution of their publications reflects their focus on eye and retinal biology.

Recent papers authored or co-authored by Lutty include:

  • Choriocapillaris: Fundamentals and advancements, 2021, Progress in Retinal and Eye Research
  • Single-cell profiling reveals an endothelium-mediated immunomodulatory pathway in the eye choroid, 2020, The Journal of Experimental Medicine
  • Choriocapillaris dropout in early age-related macular degeneration, 2020, Experimental Eye Research
  • Systemic dendrimer nanotherapies for targeted suppression of choroidal inflammation and neovascularization in age-related macular degeneration, 2021, Journal of Controlled Release
  • Evolution of oxidative stress, inflammation and neovascularization in the choroid and retina in a subretinal lipid induced age-related macular degeneration model, 2020, Experimental Eye Research

Collaborations have been a significant part of Lutty's scientific activity, with frequent co-authors including Imran Ahmed Bhutto, D. Scott McLeod, Malia M. Edwards, Rhonda Grebe, and Debasish Sinha. These partnerships indicate involvement in multidisciplinary work centered on ocular biology and disease.

Best Publications

  • Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex

    Imran Bhutto;Gerard A. Lutty

  • Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues

    Jay L. Zweier;Periannan Kuppusamy;Gerard A. Lutty

  • Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid.

    D. S. McLeod;D. J. Lefer;C. Merges;G. A. Lutty

  • Relationship between RPE and choriocapillaris in age-related macular degeneration.

    D. Scott McLeod;Rhonda Grebe;Imran Bhutto;Carol Merges

  • Choriocapillaris degeneration and related pathologic changes in human diabetic eyes.

    Jingtai Cao;D. Scott McLeod;Carol A. Merges;Gerard A. Lutty

  • Pathologic features of vascular endothelial growth factor-induced retinopathy in the nonhuman primate

    Michael J Tolentino;D.Scott Mcleod;Makoto Taomoto;Tsuyoshi Otsuji

  • Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration

    Imran A. Bhutto;D. Scott McLeod;Takuya Hasegawa;Sahng Y. Kim

  • Increase in the advanced glycation end product pentosidine in Bruch's membrane with age.

    J T Handa;N Verzijl;H Matsunaga;A Aotaki-Keen

  • High-resolution histologic analysis of the human choroidal vasculature.

    D S McLeod;G A Lutty

  • Retinal hypoxia in long-term diabetic cats.

    R A Linsenmeier;R D Braun;M A McRipley;L B Padnick

  • Determination of the mechanism of free radical generation in human aortic endothelial cells exposed to anoxia and reoxygenation.

    Jay L. Zweier;Raymond Broderick;Periannan Kuppusamy;Susan Thompson-Gorman

  • Changes in choriocapillaris and retinal pigment epithelium in age-related macular degeneration.

    Gerard Lutty;Juan Grunwald;Ajit B. Majji;Masanobu Uyama

  • Immunolocalization of TGF-beta 1, TGF-beta 2, and TGF-beta 3 in the anterior segment of the human eye.

    L R Pasquale;M E Dorman-Pease;G A Lutty;H A Quigley

  • Beyond the Definitions of the Phenotypic Complications of Sickle Cell Disease: An Update on Management

    Samir K. Ballas;Muge R. Kesen;Morton F. Goldberg;Gerard A. Lutty

  • Heterogeneity in localization of isoforms of TGF-β in human retina, vitreous, and choroid

    G A Lutty;C Merges;A B Threlkeld;S Crone

  • Quantifying changes in RPE and choroidal vasculature in eyes with age-related macular degeneration

    D. Scott McLeod;Makoto Taomoto;Tsuyoshi Otsuji;W. Richard Green

  • Relationship of polymorphonuclear leukocytes to capillary dropout in the human diabetic choroid.

    G. A. Lutty;J. Cao;D. S. McLeod

  • Pathology of Berkeley sickle cell mice: similarities and differences with human sickle cell disease.

    Elizabeth A. Manci;Cheryl A. Hillery;Carol A. Bodian;Zheng G. Zhang

  • Histopathological Insights Into Choroidal Vascular Loss in Clinically Documented Cases of Age-Related Macular Degeneration.

    Johanna M. Seddon;Johanna M. Seddon;D. Scott McLeod;Imran A. Bhutto;Mercedes B. Villalonga

  • Hypoxic retinal Muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4

    Xiaoban Xin;Murilo Rodrigues;Mahaa Umapathi;Fabiana Kashiwabuchi

Frequent Co-Authors

Johanna M. Seddon
Johanna M. Seddon University of Massachusetts Chan Medical School
Rangaramanujam M. Kannan
Rangaramanujam M. Kannan Johns Hopkins University School of Medicine
Eric F. Wawrousek
Eric F. Wawrousek National Institutes of Health
Ronald L. Nagel
Ronald L. Nagel Albert Einstein College of Medicine
Jiang Qian
Jiang Qian Johns Hopkins University School of Medicine
Gregg L. Semenza
Gregg L. Semenza Johns Hopkins University School of Medicine
José-Alain Sahel
José-Alain Sahel University of Pittsburgh
Leonard M. Hjelmeland
Leonard M. Hjelmeland University of California, Davis
Richard D. Semba
Richard D. Semba Johns Hopkins University School of Medicine
Donald J. Zack
Donald J. Zack Johns Hopkins University School of Medicine

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