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Chemistry

D-Index
41
Citations
7760
World Ranking
17696
National Ranking
784

Overview

Sylvain Rault is affiliated with the Université de Caen Normandie in France. Their research primarily lies within the field of Medicine, with a focus on several interconnected subfields including Public Health, Environmental and Occupational Health, Computational Theory and Mathematics, Oncology, Immunology, and Molecular Biology.

The topics Sylvain Rault has worked on encompass multiple areas such as:

  • Malaria Research and Control
  • Computational Drug Discovery Methods
  • Research on Leishmaniasis Studies
  • Chemokine receptors and signaling
  • Immunotherapy and Immune Responses
  • Vaccines and immunoinformatics approaches

Recent papers authored or co-authored by Sylvain Rault include:

  • A New Thienopyrimidinone Chemotype Shows Multistage Activity against Plasmodium falciparum, Including Artemisinin-Resistant Parasites, 2021, Microbiology Spectrum
  • Discovery of Bis-Imidazoline Derivatives as New CXCR4 Ligands, 2023, Molecules

Frequent co-authors with whom Sylvain Rault has collaborated are:

  • Peggy Suzanne
  • Henriette Bosson-Vanga
  • Nicolas Primas
  • Jean-François Franetich
  • Catherine Lavazec

The main publication venues for Sylvain Rault's work include Microbiology Spectrum and Molecules, each hosting at least one publication from their research efforts.

Best Publications

  • Tau protein aggregation in Alzheimer's disease: An attractive target for the development of novel therapeutic agents.

    Marie Jouanne;Sylvain Rault;Anne-Sophie Voisin-Chiret

  • Effect of A-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c][1,4]benzodiazepines.

    Thurston De;Bose Ds;Howard Pw;Jenkins Tc

  • New aromatase inhibitors. Synthesis and biological activity of aryl-substituted pyrrolizine and indolizine derivatives.

    Pascal Sonnet;Patrick Dallemagne;Jean Guillon;Cécile Enguehard

  • Synthesis of novel halopyridinylboronic acids and esters. Part 4: Halopyridin-2-yl-boronic acids and esters are stable, crystalline partners for classical Suzuki cross-coupling☆

    Alexandre Bouillon;Jean-Charles Lancelot;Jana Sopkova de Oliveira Santos;Valérie Collot

  • Reactivity of 3-Iodoimidazo[1,2-a]pyridines Using a Suzuki-Type Cross-Coupling Reaction

    Enguehard C;Renou Jl;Collot;Hervet M

  • Synthesis of new pyrrolo(1,2-a)quinoxalines: potential non-peptide glucagon receptor antagonists

    Jean Guillon;Patrick Dallemagne;Bruno Pfeiffer;Pierre Renard

  • Synthesis and structure-affinity relationships of selective high-affinity 5-HT(4) receptor antagonists: application to the design of new potential single photon emission computed tomography tracers.

    Emmanuelle Dubost;Noé Dumas;Christine Fossey;Rosa Magnelli

  • Synthesis of novel halopyridinylboronic acids and esters. Part 2: 2,4, or 5-Halopyridin-3-yl-boronic acids and esters

    Alexandre Bouillon;Jean-Charles Lancelot;Valérie Collot;Philippe R Bovy

  • Design, synthesis, and evaluation of novel thienopyrrolizinones as antitubulin agents.

    Vincent Lisowski;Stéphane Léonce;Laurence Kraus-Berthier;Jana Sopková-de Oliveira Santos

  • Novel and Selective Partial Agonists of 5-HT3 Receptors. 2. Synthesis and Biological Evaluation of Piperazinopyridopyrrolopyrazines, Piperazinopyrroloquinoxalines, and Piperazinopyridopyrroloquinoxalines

    Prunier H;Rault S;Lancelot Jc;Robba M

  • First Identification of Boronic Species as Novel Potential Inhibitors of the Staphylococcus aureus NorA Efflux Pump

    Fanny Fontaine;Arnaud Hequet;Anne-Sophie Voisin-Chiret;Alexandre Bouillon

  • Use of allostery to identify inhibitors of calmodulin-induced activation of Bacillus anthracis edema factor

    Elodie Laine;Christophe Goncalves;Johanna C. Karst;Aurélien Lesnard

  • Synthesis and biological evaluation of novel pyrrolopyrrolizinones as anticancer agents.

    C. Rochais;V. Lisowski;P. Dallemagne;S. Rault

  • Suzuki-type cross-coupling reaction of 3-iodoindazoles with aryl boronic acids: A general and flexible route to 3-arylindazoles

    Unknown

  • Synthesis of bile acid derivatives and in vitro cytotoxic activity with pro-apoptotic process on multiple myeloma (KMS-11), glioblastoma multiforme (GBM), and colonic carcinoma (HCT-116) human cell lines.

    Dominique Brossard;Laïla El Kihel;Monique Clément;Walae Sebbahi

  • Selective <i>ortho</i>-Bromination of Substituted Benzaldoximes Using Pd-Catalyzed C–H Activation: Application to the Synthesis of Substituted 2-Bromobenzaldehydes

    Unknown

  • Heck cross-coupling reaction of 3-iodoindazoles with methyl acrylate: a mild and flexible strategy to design 2-aza tryptamines

    Valérie Collot;Didier Varlet;Sylvain Rault

  • Nanocarriers for the targeted treatment of ovarian cancers

    Unknown

  • New benzo[h][1,6]naphthyridine and azepino[3,2-c]quinoline derivatives as selective antagonists of 5-HT4 receptors: binding profile and pharmacological characterization.

    Antoine Hinschberger;Sabrina Butt;Véronique Lelong;Michel Boulouard

  • Synthesis and biological evaluation of five-membered heterocycles fused to cyclopenta[c]thiophene as new antitumor agents.

    Patrick Dallemagne;Lan Pham Khanh;Abdellah Alsaı̈di;Isabelle Varlet

  • The design of donecopride, a dual 5-HT4R agonist/AChE inhibitor with potential interest for AD treatment

    Cédric Lecoutey;Damien Hedou;Thomas Freret;Patrizia Giannoni

  • Synthesis and in vitro antiplasmodial evaluation of 4-anilino-2-trichloromethylquinazolines

    Pierre Verhaeghe;Nadine Azas;Sébastien Hutter;Caroline Castera-Ducros

  • Design, synthesis and antiproliferative activity of tripentones: a new series of antitubulin agents.

    Vincent Lisowski;Cécile Enguehard;Jean-Charles Lancelot;Daniel-Henri Caignard

Frequent Co-Authors

Philippe Delagrange
Philippe Delagrange Centre national de la recherche scientifique, CNRS
Laurent Poulain
Laurent Poulain Leibniz Association
Denis Vivien
Denis Vivien Université de Caen Normandie
Aline Dumuis
Aline Dumuis Centre national de la recherche scientifique, CNRS
Jérôme Leprince
Jérôme Leprince University of Rouen
Jean A. Boutin
Jean A. Boutin Institut de Recherches Internationales Servier
Daniel Ladant
Daniel Ladant Institut Pasteur
Laurent Meijer
Laurent Meijer Perha Pharmaceuticals
Wei-Jen Tang
Wei-Jen Tang University of Chicago
Jean-Michel Léger
Jean-Michel Léger University of Poitiers

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