World's Best Scientists 2026 revealed!

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Biology and Biochemistry

D-Index
58
Citations
16823
World Ranking
12971
National Ranking
5529

Research.com Recognitions

  • 1994 - Oswald Avery Award, Infectious Diseases Society of America
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Mark S. Klempner is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with particular focus on Infectious Diseases, Endocrinology, Molecular Biology, Radiology, Nuclear Medicine and Imaging, and Immunology.

The main research topics covered in their work include:

  • Viral gastroenteritis research and epidemiology
  • Escherichia coli research studies
  • Monoclonal and Polyclonal Antibodies Research
  • SARS-CoV-2 and COVID-19 Research
  • Transgenic Plants and Applications
  • COVID-19 Clinical Research Studies
  • Bacteriophages and microbial interactions

They have published multiple papers, with some recent examples being:

  • A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction, 2020, Nature Communications
  • Anti-CfaE nanobodies provide broad cross-protection against major pathogenic enterotoxigenic Escherichia coli strains, with implications for vaccine design, 2021, Scientific Reports
  • Enteric Polymer-Coated Porous Silicon Nanoparticles for Site-Specific Oral Delivery of IgA Antibody, 2020, ACS Biomaterials Science & Engineering
  • IgA MAb blocks SARS-CoV-2 Spike-ACE2 interaction providing mucosal immunity, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Oral administration of an anti-CfaE secretory IgA antibody protects against Enterotoxigenic Escherichia coli diarrheal disease in a nonhuman primate model, 2020, Vaccine

Their work has been published frequently in venues such as Scientific Reports, bioRxiv (Cold Spring Harbor Laboratory), Vaccine, Nature Communications, and ACS Biomaterials Science & Engineering.

Among frequent co-authors are:

  • Lisa A. Cavacini
  • Yang Wang
  • Monir Ejemel
  • Zachary A. Schiller
  • Aaron Wallace

Mark S. Klempner has been recognized with awards including the Oswald Avery Award from the Infectious Diseases Society of America in 1994 and is a member of the Association of American Physicians.

Best Publications

  • The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America

    Gary P. Wormser;Raymond J. Dattwyler;Eugene D. Shapiro;John J. Halperin

  • The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells

    S Endres;R Ghorbani;V E Kelley;K Georgilis

  • Two Controlled Trials of Antibiotic Treatment in Patients with Persistent Symptoms and a History of Lyme Disease

    Mark S. Klempner;Linden T. Hu;Janine Evans;Christopher H. Schmid

  • Characterization of the surface enhanced raman scattering (SERS) of bacteria.

    W. R. Premasiri;D. T. Moir;M. S. Klempner;N. Krieger

  • A vaccine consisting of recombinant Borrelia burgdorferi outer-surface protein A to prevent lyme disease

    L H Sigal;J M Zahradnik;P Lavin;S J Patella

  • Erratum: The clinical assessment, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: Clinical practice guidelines by the Infectious Diseases Society of America (Clinical Infectious Diseases (2006) 43, (1089-1134))

    G. P. Wormser;R. J. Dattwyler;E. D. Shapiro;John Halperin

  • An inherited abnormality of neutrophil adhesion. Its genetic transmission and its association with a missing protein.

    Carol A. Crowley;John T. Curnutte;Richard E. Rosin;Janine André-Schwartz

  • Central nervous system disease in systemic lupus erythematosus: Therapy and prognosis

    John S. Sergent;Michael D. Lockshin;Mark S. Klempner;Benjamin A. Lipsky

  • Human leukocytic pyrogen induces release of specific granule contents from human neutrophils.

    Mark S. Klempner;Charles A. Dinarello;John I. Gallin

  • Yersinia pestis pH 6 antigen: genetic, biochemical, and virulence characterization of a protein involved in the pathogenesis of bubonic plague.

    L E Lindler;M S Klempner;S C Straley

  • Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak

    Zachary A. Bornholdt;Hannah L. Turner;Charles D. Murin;Wen Li

  • Cognitive function in post-treatment Lyme disease Do additional antibiotics help?

    R. F. Kaplan;R. P. Trevino;G. M. Johnson;L. Levy

  • Two functional domains in the phagocyte membrane glycoprotein Mo1 identified with monoclonal antibodies.

    N Dana;B Styrt;J D Griffin;R F Todd

  • An acquired chemotactic defect in neutrophils from patients receiving interleukin-2 immunotherapy

    Mark S. Klempner;Richard Noring;James W. Mier;Michael B. Atkins

  • Neutrophil plasma membranes. I. High-yield purification of human neutrophil plasma membrane vesicles by nitrogen cavitation and differential centrifugation.

    M S Klempner;R B Mikkelsen;D H Corfman;J André-Schwartz

  • Invasion of Human Skin Fibroblasts by the Lyme Disease Spirochete, Borrelia burgdorferi

    Mark S. Klempner;Richard Noring;Rick A. Rogers

  • Salmonella typhimurium intercepts Escherichia coli signaling to enhance antibiotic tolerance

    Nicole M. Vega;Kyle R. Allison;Kyle R. Allison;Amanda N. Samuels;Amanda N. Samuels;Mark S. Klempner

  • Clindamycin Uptake by Human Neutrophils

    Mark S. Klempner;Barbara Styrt

  • Separation and functional characterization of human neutrophil subpopulations

    Mark S. Klempner;John I. Gallin

  • Human recombinant interleukin 1 beta has no effect on intracellular calcium or on functional responses of human neutrophils.

    K Georgilis;C Schaefer;C A Dinarello;M S Klempner

Frequent Co-Authors

Lisa A. Cavacini
Lisa A. Cavacini University of Massachusetts Chan Medical School
Allen C. Steere
Allen C. Steere Harvard University
Gary P. Wormser
Gary P. Wormser New York Medical College
Ross E. Rocklin
Ross E. Rocklin Tufts Medical Center
Charles A. Dinarello
Charles A. Dinarello University of Colorado Anschutz Medical Campus
James W. Mier
James W. Mier Beth Israel Deaconess Medical Center
John I. Gallin
John I. Gallin National Institutes of Health
Christopher H. Schmid
Christopher H. Schmid Brown University
Celia A. Schiffer
Celia A. Schiffer University of Massachusetts Chan Medical School
Peter J. Krause
Peter J. Krause Yale University

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