World's Best Scientists 2026 revealed!
Mathias Ziegler

Mathias Ziegler

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
12333
World Ranking
14350
National Ranking
72

Overview

Mathias Ziegler is affiliated with the University of Bergen in Norway and has contributed extensively to the fields of biochemistry, genetics, and molecular biology, as well as medicine. Their research encompasses a broad range of topics, with a significant focus on molecular biology and physiology. Ziegler's work also spans geriatric and gerontological studies, oncology, and epidemiology dimensions of medical research.

The scientist's main areas of study include:

  • Calcium signaling and nucleotide metabolism
  • Mitochondrial function and pathology
  • Sirtuins and resveratrol in medicine
  • PARP inhibition in cancer therapy
  • Biochemical and molecular research
  • Thermography and photoacoustic techniques
  • Pluripotent stem cells research

Ziegler has published research in a variety of journals, with multiple contributions to bioRxiv (Cold Spring Harbor Laboratory) and arXiv (Cornell University). Other frequently used publication venues include Nature Metabolism, Mechanisms of Ageing and Development, and Biomolecules.

Recent notable papers include:

  • "Regulation of and challenges in targeting NAD+ metabolism," 2024, Nature Reviews Molecular Cell Biology
  • "The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease," 2022, Cell Metabolism
  • "ADP-ribosyltransferases, an update on function and nomenclature," 2021, FEBS Journal
  • "SLC25A51 is a mammalian mitochondrial NAD+ transporter," 2020, Nature
  • "Disease-specific phenotypes in iPSC -derived neural stem cells with POLG mutations," 2020, EMBO Molecular Medicine

Frequent co-authors in Ziegler's publications comprise Marie E. Migaud, Lena Elise Høyland, Marc Niere, Ines Heiland, and Lars J. Sverkeli, indicating collaborations across multiple related research projects and fields.

Best Publications

  • The power to reduce: pyridine nucleotides – small molecules with a multitude of functions

    Nadine Pollak;Christian Dölle;Mathias Ziegler

  • The NAD metabolome — a key determinant of cancer cell biology

    Alberto Chiarugi;Christian Dölle;Roberta Felici;Mathias Ziegler

  • The new life of a centenarian: signalling functions of NAD(P).

    Felicitas Berger;Marı́a H. Ramı́rez-Hernández;Mathias Ziegler;Mathias Ziegler

  • Subcellular Compartmentation and Differential Catalytic Properties of the Three Human Nicotinamide Mononucleotide Adenylyltransferase Isoforms

    Felicitas Berger;Corinna Lau;Mathias Dahlmann;Mathias Ziegler

  • Separating NADH and NADPH fluorescence in live cells and tissues using FLIM.

    Thomas S. Blacker;Zoe F. Mann;Jonathan E. Gale;Mathias Ziegler

  • New functions of a long-known molecule. Emerging roles of NAD in cellular signaling.

    Mathias Ziegler

  • Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells FROM ENTRY OF EXTRACELLULAR PRECURSORS TO MITOCHONDRIAL NAD GENERATION

    Andrey Nikiforov;Christian Dölle;Marc Niere;Mathias Ziegler

  • SLC25A51 is a mammalian mitochondrial NAD + transporter

    Timothy S. Luongo;Jared M. Eller;Mu Jie Lu;Marc Niere

  • NAD kinase levels control the NADPH concentration in human cells.

    Nadine Pollak;Marc Niere;Mathias Ziegler

  • The human NAD metabolome: Functions, metabolism and compartmentalization

    Andrey Nikiforov;Veronika Kulikova;Mathias Ziegler

  • Structural and functional characterization of human NAD kinase.

    Felicitas Lerner;Marc Niere;Antje Ludwig;Mathias Ziegler

  • Pathophysiological relevance of mitochondria in NAD+ metabolism

    Fabio Di Lisa;Mathias Ziegler

  • ADP-ribosyltransferases, an update on function and nomenclature

    Bernhard Lüscher;Ivan Ahel;Matthias Altmeyer;Alan Ashworth

  • The phosphate makes a difference: cellular functions of NADP.

    Line Agledal;Marc Niere;Mathias Ziegler

  • ATP for the DNA ligation step in base excision repair is generated from poly(ADP-ribose).

    Shiao Li Oei;Mathias Ziegler

  • Characterization of recombinant human nicotinamide mononucleotide adenylyl transferase (NMNAT), a nuclear enzyme essential for NAD synthesis.

    Manfred Schweiger;Klaus Hennig;Felicitas Lerner;Marc Niere

  • A cellular survival switch: poly(ADP-ribosyl)ation stimulates DNA repair and silences transcription.

    Mathias Ziegler;Shiao Li Oei

  • Regulation of RNA Polymerase II-dependent Transcription by Poly(ADP-ribosyl)ation of Transcription Factors

    Shiao Li Oei;Joachim Griesenbeck;Manfred Schweiger;Mathias Ziegler

  • Regulation of glutamate dehydrogenase by reversible ADP-ribosylation in mitochondria.

    Andrés Herrero‐Yraola;Siham M.A. Bakhit;Peter Franke;Christoph Weise

  • Compartmentation of NAD+-dependent Signalling

    Friedrich Koch-Nolte;Stefan Fischer;Friedrich Haag;Mathias Ziegler

Frequent Co-Authors

Manfred Schweiger
Manfred Schweiger Freie Universität Berlin
Thomas Arnesen
Thomas Arnesen University of Bergen
Udo Heinemann
Udo Heinemann Max Delbrück Center for Molecular Medicine
Friedrich Koch-Nolte
Friedrich Koch-Nolte Universität Hamburg
Stefan Schuster
Stefan Schuster Friedrich Schiller University Jena
Christoph Weise
Christoph Weise Freie Universität Berlin
Axel A. Brakhage
Axel A. Brakhage Leibniz Association
Laurence A. Bindoff
Laurence A. Bindoff Haukeland University Hospital
Johan R. Lillehaug
Johan R. Lillehaug University of Bergen
Sandip Patel
Sandip Patel University College London

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