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Biology and Biochemistry

D-Index
61
Citations
11474
World Ranking
11504
National Ranking
298

Overview

Lodewijk IJlst is affiliated with the University of Amsterdam in the Netherlands and specializes in biochemistry, genetics, and molecular biology. Their research primarily focuses on metabolism and genetic disorders, with significant contributions in the study of peroxisome proliferator-activated receptors as well as RNA research, including RNA modifications, cancer, and splicing. Additional areas of interest include diet and metabolism studies, mitochondrial function and pathology, and cancer-related gene regulation.

They have published extensively, with their work appearing in a variety of scientific journals. Frequent publication venues include:

  • Frontiers in Cell and Developmental Biology
  • Genetics in Medicine
  • Journal of Inherited Metabolic Disease
  • bioRxiv (Cold Spring Harbor Laboratory)
  • International Journal of Molecular Sciences

Their recent papers reflect a focus on cellular metabolism and genetic disorders and include:

  • "Peroxisomal Metabolite and Cofactor Transport in Humans," 2021, Frontiers in Cell and Developmental Biology
  • "An autosomal dominant neurological disorder caused by de novo variants in FAR1 resulting in uncontrolled synthesis of ether lipids," 2020, Genetics in Medicine
  • "Nutritional ketosis improves exercise metabolism in patients with very long-chain acyl-CoA dehydrogenase deficiency," 2020, Journal of Inherited Metabolic Disease
  • "Electrophysiological Abnormalities in VLCAD Deficient hiPSC-Cardiomyocytes Can Be Improved by Lowering Accumulation of Fatty Acid Oxidation Intermediates," 2020, International Journal of Molecular Sciences
  • "The Saccharomyces cerevisiae ABC subfamily D transporter Pxa1/Pxa2p co-imports CoASH into the peroxisome," 2020, FEBS Letters

This researcher often collaborates with colleagues including Ronald J. A. Wanders, Hans R. Waterham, Sacha Ferdinandusse, Riekelt H. Houtkooper, and Carlo W.T. van Roermund.

Lodewijk IJlst has also contributed to academic books, such as a volume published by Frontiers Media titled "Molecular Mechanisms and Physiological Significance of Organelle Interactions and Cooperation - Volume II" in 2022.

Best Publications

  • Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation: A review

    M. F. B. Silva;C. C. P. Aires;P. B. M. Luis;J. P. N. Ruiter

  • Disorders of mitochondrial fatty acyl-CoA β-oxidation

    R. J. A. Wanders;R. J. A. Wanders;P. Vreken;P. Vreken;M. E. J. den Boer;M. E. J. den Boer;F. A. Wijburg;F. A. Wijburg

  • Clear Correlation of Genotype with Disease Phenotype in Very–Long-Chain Acyl-CoA Dehydrogenase Deficiency

    Brage Storstein Andresen;Brage Storstein Andresen;Simon Olpin;Ben J.H.M. Poorthuis;Hans R. Scholte

  • Refsum disease is caused by mutations in the phytanoyl-CoA hydroxylase gene

    G. A. Jansen;R. Ofman;S. Ferdinandusse;L. Ijlst

  • Brown-Vialetto-Van Laere and Fazio Londe syndrome is associated with a riboflavin transporter defect mimicking mild MADD: a new inborn error of metabolism with potential treatment

    Annet M. Bosch;Nico G. G. M. Abeling;Lodewijk IJlst;Hennie Knoester

  • Disorders of mitochondrial long-chain fatty acid oxidation and the carnitine shuttle

    Suzan J. G. Knottnerus;Suzan J. G. Knottnerus;Jeannette C. Bleeker;Jeannette C. Bleeker;Rob C. I. Wüst;Sacha Ferdinandusse

  • Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact.

    Nadav Shai;Eden Yifrach;Carlo W. T. van Roermund;Nir Cohen

  • Subcellular localization and physiological role of alpha-methylacyl-CoA racemase.

    Sacha Ferdinandusse;Simone Denis;Lodewijk IJlst;Georges Dacremont

  • The human peroxisomal ABC half transporter ALDP functions as a homodimer and accepts acyl-CoA esters

    Carlo W. T. van Roermund;Wouter F. Visser;Lodewijk IJlst;Arno van Cruchten

  • Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency: Clinical Presentation and Follow-Up of 50 Patients

    Margarethe E. J. den Boer;Ronald J. A. Wanders;Andrew A. M. Morris;Lodewijk IJlst

  • The enzymology of mitochondrial fatty acid beta-oxidation and its application to follow-up analysis of positive neonatal screening results

    Ronald J. A. Wanders;Jos P. N. Ruiter;Lodewijk IJlst;Hans R. Waterham

  • Human trifunctional protein deficiency: a new disorder of mitochondrial fatty acid beta-oxidation.

    R.J.A. Wanders;L. Ijlst;F. Poggi;J.P. Bonnefont

  • Common missense mutation G1528C in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. Characterization and expression of the mutant protein, mutation analysis on genomic DNA and chromosomal localization of the mitochondrial trifunctional protein alpha subunit gene.

    L IJlst;J P Ruiter;J M Hoovers;M E Jakobs

  • Metabolite transport across the peroxisomal membrane

    Wouter F. Visser;Carlo W. T. van Roermund;Lodewijk Ijlst;Hans R. Waterham

  • Molecular basis of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency: identification of the major disease-causing mutation in the alpha-subunit of the mitochondrial trifunctional protein.

    Lodewijk IJlst;Ronald J.A. Wanders;Sciichi Ushikubo;Takehiko Kamijo

  • SUDDEN INFANT DEATH AND LONG-CHAIN 3-HYDROXYACYL-CoA DEHYDROGENASE

    R.J.A. Wanders;M. Duran;L. Ijlst;J.P. De Jager

  • Peroxisomal d-hydroxyacyl-CoA dehydrogenase deficiency: Resolution of the enzyme defect and its molecular basis in bifunctional protein deficiency

    E. G. Van Grunsven;E. Van Berkel;L. Ijlst;P. Vreken

  • Clinical, biochemical, and mutational spectrum of peroxisomal acyl-coenzyme A oxidase deficiency.

    Sacha Ferdinandusse;Simone Denis;Eveline M. Hogenhout;Janet Koster

  • Cloning of the human carnitine-acylcarnitine carrier cDNA and identification of the molecular defect in a patient

    Marjan Huizing;Vito Iacobazzi;Lodewijk IJlst;Paul Savelkoul

  • The Brown-Vialetto-Van Laere and Fazio Londe syndrome revisited: natural history, genetics, treatment and future perspectives

    Annet M Bosch;Kevin Stroek;Nico G Abeling;Hans R Waterham

Frequent Co-Authors

Ronald J.A. Wanders
Ronald J.A. Wanders University of Amsterdam
Hans R. Waterham
Hans R. Waterham University of Amsterdam
Jos P.N. Ruiter
Jos P.N. Ruiter University of Amsterdam
Frits A. Wijburg
Frits A. Wijburg University of Amsterdam
Marinus Duran
Marinus Duran University of Amsterdam
Sacha Ferdinandusse
Sacha Ferdinandusse University of Amsterdam
Sander M. Houten
Sander M. Houten Icahn School of Medicine at Mount Sinai
Frédéric M. Vaz
Frédéric M. Vaz University of Amsterdam
Riekelt H. Houtkooper
Riekelt H. Houtkooper University of Amsterdam
Brage S. Andresen
Brage S. Andresen University of Southern Denmark

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