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Biology and Biochemistry

D-Index
52
Citations
24958
World Ranking
16421
National Ranking
6790

Overview

Kiichi Nakahira is a researcher affiliated with Cornell University in the United States. Their work spans multiple disciplines within medicine and the molecular biosciences, focusing extensively on mitochondrial function, immunology, and respiratory medicine.

The main fields of study for Nakahira include Medicine and Biochemistry, Genetics and Molecular Biology. Specific subfields they frequently explore are Molecular Biology, Pulmonary and Respiratory Medicine, Immunology, Physiology, and Cancer Research.

Key research topics they focus on include:

  • Mitochondrial Function and Pathology
  • Inflammasome and immune disorders
  • Respiratory Support and Mechanisms
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Immune Cell Function and Interaction
  • Extracellular vesicles in disease
  • Air Quality and Health Impacts

Some recent papers featuring their contributions are:

  • Cell-free DNA (cfDNA) and Exosome Profiling from a Year-Long Human Spaceflight Reveals Circulating Biomarkers, 2020, iScience
  • Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort, 2020, JCI Insight
  • Cell-free DNA in human ex vivo lung perfusate as a potential biomarker to predict the risk of primary graft dysfunction in lung transplantation, 2020, Journal of Thoracic and Cardiovascular Surgery
  • Conditional deletion of myeloid-specific mitofusin 2 but not mitofusin 1 promotes kidney fibrosis, 2022, Kidney International
  • Circulating N-formylmethionine and metabolic shift in critical illness: a multicohort metabolomics study, 2022, Critical Care

Nakahira has collaborated frequently with several researchers, including:

  • Augustine M.K. Choi
  • Masanori Yoshizumi
  • Yoji Kyotani
  • Jing Zhao
  • Kuei-Pin Chung

Their work has appeared often in the Proceedings for Annual Meeting of The Japanese Pharmacological Society, with additional publications in JCI Insight, Scientific Reports, bioRxiv (Cold Spring Harbor Laboratory), and the Journal of the American Society of Nephrology.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

    Kiichi Nakahira;Jeffrey Adam Haspel;Jeffrey Adam Haspel;Vijay A.K. Rathinam;Seon Jin Lee

  • Mechanisms of cell death in oxidative stress.

    Stefan W. Ryter;Hong Pyo Kim;Alexander Hoetzel;Jeong W. Park

  • The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight.

    Francine E. Garrett-Bakelman;Francine E. Garrett-Bakelman;Manjula Darshi;Stefan J. Green;Ruben C. Gur

  • Fatty Acids Modulate Toll-like Receptor 4 Activation through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner

    Scott William Wong;Myung-Ja Kwon;Augustine M. K. Choi;Hong-Pyo Kim

  • Inflammasome-regulated cytokines are critical mediators of acute lung injury.

    Tamás Dolinay;Young Sam Kim;Judie Howrylak;Gary M. Hunninghake

  • Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD

    Kenji Mizumura;Kenji Mizumura;Kenji Mizumura;Suzanne M. Cloonan;Suzanne M. Cloonan;Kiichi Nakahira;Kiichi Nakahira;Abhiram R. Bhashyam

  • Egr-1 Regulates Autophagy in Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease

    Zhi Hua Chen;Hong Pyo Kim;Hong Pyo Kim;Frank C. Sciurba;Seon Jin Lee;Seon Jin Lee

  • Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation

    Kiichi Nakahira;Sun-Young Kyung;Angela J. Rogers;Lee Gazourian

  • Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts

    Kiichi Nakahira;Hong Pyo Kim;Xue Hui Geng;Atsunori Nakao

  • mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation

    Jong Seok Moon;Jong Seok Moon;Shu Hisata;Shu Hisata;Mi Ae Park;Gina M. DeNicola

  • The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases.

    Kiichi Nakahira;Shu Hisata;Shu Hisata;Augustine M.K. Choi;Augustine M.K. Choi

  • The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1.

    Xiao Mei Wang;Hong Pyo Kim;Kiichi Nakahira;Stefan W. Ryter

  • NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages

    Jong Seok Moon;Kiichi Nakahira;Kiichi Nakahira;Kuei Pin Chung;Kuei Pin Chung;Kuei Pin Chung;Gina M. DeNicola

  • Carbon monoxide protects against hyperoxia-induced endothelial cell apoptosis by inhibiting reactive oxygen species formation.

    Xue Wang;Yong Wang;Hong Pyo Kim;Kiichi Nakahira

  • Comparison of qSOFA and SIRS for predicting adverse outcomes of patients with suspicion of sepsis outside the intensive care unit.

    Eli J. Finkelsztein;Daniel S. Jones;Kevin C. Ma;Maria A. Pabón

  • UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis

    Jong Seok Moon;Jong Seok Moon;Seonmin Lee;Seonmin Lee;Mi Ae Park;Ilias I. Siempos;Ilias I. Siempos;Ilias I. Siempos

  • BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension.

    Isabel Diebold;Jan K. Hennigs;Kazuya Miyagawa;Caiyun G. Li

  • Metabolomic derangements are associated with mortality in critically ill adult patients.

    Angela J. Rogers;Michael McGeachie;Rebecca M. Baron;Lee Gazourian

  • Mitochondria in lung biology and pathology: more than just a powerhouse

    Paul T. Schumacker;Mark N. Gillespie;Kiichi Nakahira;Augustine M. K. Choi

Frequent Co-Authors

Augustine M. K. Choi
Augustine M. K. Choi Cornell University
Stefan W. Ryter
Stefan W. Ryter Cornell University
Fernando J. Martinez
Fernando J. Martinez University of Massachusetts Chan Medical School
Jeffrey L. Curtis
Jeffrey L. Curtis University of Michigan–Ann Arbor
MeiLan K. Han
MeiLan K. Han University of Michigan–Ann Arbor
Stephen P. Peters
Stephen P. Peters Wake Forest University
Karla V. Ballman
Karla V. Ballman Cornell University
Noriko Murase
Noriko Murase University of Pittsburgh
Nadia N. Hansel
Nadia N. Hansel Johns Hopkins University
Shigeru Sassa
Shigeru Sassa Rockefeller University

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