World's Best Scientists 2026 revealed!

Overview

Philip L. Grover is affiliated with the Institute of Cancer Research in the United Kingdom. Their research primarily focuses on molecular mechanisms underlying protein misfolding and aggregation, with a significant concentration on prion diseases and related neurodegenerative conditions.

Their publications span various respected journals and platforms, including Nature Communications, Brain, Proceedings of the National Academy of Sciences, ACS Chemical Neuroscience, and bioRxiv (Cold Spring Harbor Laboratory). Recent papers include:

  • "NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62" (2023, Nature Communications)
  • "Cross-seeding by prion protein inactivates TDP-43" (2023, Brain)
  • "NEMO reshapes the protein aggregate interface and promotes aggrephagy by co-condensation with p62" (2023, bioRxiv)
  • "Topological confinement by a membrane anchor suppresses phase separation into protein aggregates: Implications for prion diseases" (2024, Proceedings of the National Academy of Sciences)
  • "Soluble N-Terminal Domain of the Prion Protein Interferes with Fibrillization of α-Synuclein to Form Off-Pathway Assemblies that Lack Cellular Seeding Activity" (2025, ACS Chemical Neuroscience)

The scientist has collaborated frequently with several co-authors, including Jörg Tatzelt, Konstanze F. Winklhofer, Verian Bader, Laura J. Krause, and Markus Glatzel. This network suggests a focus on multidisciplinary approaches involving protein biology, neurobiology, and related fields.

Philip L. Grover's work is primarily situated within the broader fields of biochemistry, genetics, molecular biology, and medicine. Their key subfields of study encompass molecular biology, neurology, epidemiology, oncology, and nutrition and dietetics.

The main research topics covered across their publications include:

  • Prion Diseases and Protein Misfolding
  • Autophagy in Disease and Therapy
  • Ubiquitin and Proteasome Pathways
  • Neurological Diseases and Metabolism
  • RNA Regulation and Disease
  • Amyotrophic Lateral Sclerosis Research
  • Peptidase Inhibition and Analysis

Best Publications

  • Formation of K-region epoxides as microsomal metabolites of pyrene and benzo(a)pyrene.

    P.L. Grover;A. Hewer;P. Sims

  • Fluorescence spectral evidence that benzo(a)pyrene-DNA products in mouse skin arise from diol-epoxides

    Pascaline Daudel;Maurice Duquesne;Paul Vigny;Philip L. Grover

  • In Vitro Transformation of Rodent Cells by K-Region Derivatives of Polycyclic Hydrocarbons

    Philip L. Grover;Peter Sims;Eliezer Huberman;Hans Marquardt

  • Mutagenicity of non-K-region diols and diol-epoxides of benz(a)anthracene and benzo(a)pyrene in S. typhimurium TA 100.

    C. Malaveille;H. Bartsch;P.L. Grover;P. Sims

  • Malignant transformation of cells derived from mouse prostate by epoxides and other derivatives of polycyclic hydrocarbons.

    Hans Marquardt;Toshio Kuroki;Eliezer Huberman;James K. Selkirk

  • Mutagenicity to Mammalian Cells of Epoxides and Other Derivatives of Polycyclic Hydrocarbons

    Eliezer Huberman;Lourdes Aspiras;Charles Heidelberger;Philip L. Grover

  • Monitoring occupational exposure to carcinogens: detection by 32P-postlabelling of aromatic DNA adducts in white blood cells from iron foundry workers

    David H. Phillips;Kari Hemminki;Anneli Alhonen;Alan Hewer

  • Studies on the Formation of Hydrocarbon-Deoxyribonucleoside Products by the Binding of Derivatives of 7-Methylbenz[a]anthracene to DNA in Aqueous Solution and in Mouse Embryo Cells in Culture

    William M. Baird;Anthony Dipple;Philip L. Grover;Peter Sims

  • Transformation of Hamster Embryo Cells by Epoxides and Other Derivatives of Polycyclic Hydrocarbons

    Eliezer Huberman;Toshio Kuroki;Hans Marquardt;James K. Selkirk

  • Interactions of the k-region epoxides of phenanthrene and dibenz[a,h]anthracene with nucleic acids and histone

    P.L. Grover;P. Sims

  • Polycyclic Hydrocarbon Activation: Bay Regions and Beyond

    David H. Phillips;Philip L. Grover

  • Aromatic DNA adducts in human bone marrow and peripheral blood leukocytes.

    David H. Phillips;Alan Hewer;Philip L. Grover

  • In Vitro Malignant Transformation of Mouse Fibroblasts by Non-K-Region Dihydrodiols Derived from 7-Methylbenz(a)anthracene, 7,12-Dimethylbenz(a)anthracene, and Benzo(a)pyrene

    Hans Marquardt;Philip L. Grover;Peter Sims

  • The covalent binding of polycyclic hydrocarbons to DNA in the skin of mice of different strains.

    David H. Phillips;Philip L. Grover;Peter Sims

  • The initiation of breast and prostate cancer.

    Philip L. Grover;Francis L. Martin

  • Heterocyclic aromatic amines induce DNA strand breaks and cell transformation.

    Wolfgang Pfau;Francis L. Martin;Kathleen J. Cole;Stanley Venitt

  • The metabolic activation of 7-methylbenz(a)anthracene in mouse skin.

    Brian Tierney;Alan Hewer;Christine Walsh;Philip L. Grover

  • Mutagenicity of isomeric diol-epoxides of benzo[a]pyrene and benz[a]anthracene in S. typhimurium TA98 and TA100 and in V79 Chinese hamster cells.

    C. Malaveille;T. Kuroki;P. Sims;P.L. Grover

  • The DNA repair inhibitors hydroxyurea and cytosine arabinoside enhance the sensitivity of the alkaline single-cell gel electrophoresis (`comet') assay in metabolically-competent MCL-5 cells

    Francis L Martin;Kathleen J Cole;Mariam H Orme;Philip L Grover

  • 3 – Involvement of Dihydrodiols and Diol Epoxides in the Metabolic Activation of Polycyclic Hydrocarbons Other than Benzo[a]pyrene

    Peter Sims;Philip L. Grover

Frequent Co-Authors

David H. Phillips
David H. Phillips King's College London
Peter J. Sims
Peter J. Sims University of Rochester
Francis Martin
Francis Martin University of Lorraine
Charles Heidelberger
Charles Heidelberger University of Southern California
Eliezer Huberman
Eliezer Huberman University of Illinois at Chicago
Helmut Bartsch
Helmut Bartsch German Cancer Research Center
Franz Oesch
Franz Oesch Johannes Gutenberg University of Mainz
Toshio Kuroki
Toshio Kuroki Showa University
Hansruedi Glatt
Hansruedi Glatt Federal Institute for Risk Assessment
Bridget T. Hill
Bridget T. Hill The Honourable Society of Lincoln's Inn

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

If you're considering a future in Biology or Biochemistry, there are several related online degree options and career pathways worth exploring. Fields like medical billing and coding, is medical coding a dying career, have adapted to technology-driven healthcare but may face evolving job prospects due to automation. It's important to weigh both the opportunities and challenges in these areas.

Health information continues to be a critical part of modern medicine, making roles in health information management schools online a popular choice. These programs blend healthcare and technology, offering flexible learning for future professionals.

Interested in nutrition science? Earning a masters in nutrition online can open doors to roles in research, clinical settings, or health education.

Diagnostic imaging is another growing area. If technology and patient care appeal to you, explore accredited online ultrasound tech school programs that prepare you for a rewarding career in healthcare.

Best Scientists Citing Philip L. Grover

Trending Scientists