What is he best known for?
The fields of study he is best known for:
His primary scientific interests are in Biochemistry, Molecular biology, Cell culture, Transformation and Carcinogenesis.
His Biochemistry study frequently links to adjacent areas such as Thymidylate synthase.
His work deals with themes such as Cell division and Thymidine, which intersect with Molecular biology.
His Cell culture research incorporates elements of In vitro and Embryo.
He has researched Transformation in several fields, including Methylcholanthrene, Clone, Hamster and Tissue culture.
His research in Carcinogenesis intersects with topics in Cell, Oncology and Chemotherapy Cancer.
His most cited work include:
- Fluorinated Pyrimidines, A New Class of Tumour-Inhibitory Compounds (1201 citations)
- Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division. (955 citations)
- Quantitative and qualitative studies of chemical transformation of cloned C3H mouse embryo cells sensitive to postconfluence inhibition of cell division. (764 citations)
What are the main themes of his work throughout his whole career to date?
Charles Heidelberger mainly focuses on Biochemistry, Molecular biology, Carcinogenesis, Carcinogen and Cell culture.
Enzyme and Ehrlich ascites carcinoma is closely connected to Thymidylate synthase in his research, which is encompassed under the umbrella topic of Biochemistry.
Charles Heidelberger combines subjects such as Neoplasm, Cytotoxicity, Transformation, Embryo and Tissue culture with his study of Molecular biology.
His studies in Carcinogenesis integrate themes in fields like Cancer research and Hydrocarbon.
His work in Cell culture tackles topics such as In vitro which are related to areas like Antigen.
The study incorporates disciplines such as HeLa, Nucleic acid and Stereochemistry in addition to DNA.
He most often published in these fields:
- Biochemistry (41.52%)
- Molecular biology (24.57%)
- Carcinogenesis (13.49%)
What were the highlights of his more recent work (between 1977-2017)?
- Molecular biology (24.57%)
- Biochemistry (41.52%)
- Cell culture (13.49%)
In recent papers he was focusing on the following fields of study:
His primary areas of study are Molecular biology, Biochemistry, Cell culture, Carcinogen and Transformation.
His Molecular biology research integrates issues from Mutation, Clone, Cytotoxicity, Embryo and Tissue culture.
His studies link Thymidylate synthase with Biochemistry.
His Cell culture study combines topics in areas such as Epithelium, Pyrene, Phenotype, Cell division and Cytotoxic T cell.
His research integrates issues of Glutathione and Mutant in his study of Carcinogen.
His Transformation research is multidisciplinary, incorporating elements of Carcinogenesis, Cell and Cell biology.
Between 1977 and 2017, his most popular works were:
- In Vivo Kinetics of Thymidylate Synthetase Inhibition in 5-Fluorouracil-sensitive and -resistant Murine Colon Adenocarcinomas (248 citations)
- Cell transformation by chemical agents--a review and analysis of the literature. A report of the U.S. Environmental Protection Agency Gene-Tox Program. (194 citations)
- Biochemical determinants of tumor sensitivity to 5-fluorouracil: Ultrasensitive methods for the determination of 5-fluoro-2′-deoxyuridylate, 2′-deoxyuridylate, and thymidylate synthetase (113 citations)
In his most recent research, the most cited papers focused on:
Charles Heidelberger mostly deals with Molecular biology, Biochemistry, Cell culture, Thymidylate synthase and Genetics.
His biological study spans a wide range of topics, including Neoplasm, Enzyme, Clone, Cytotoxicity and Tissue culture.
His study in the fields of Deoxyuridine, DNA, Nucleotide and Nucleoside under the domain of Biochemistry overlaps with other disciplines such as 12-O-Tetradecanoylphorbol-13-acetate.
Charles Heidelberger interconnects Inducer, Benzopyrene, Anthracene, Microsome and Cytochrome in the investigation of issues within Cell culture.
His Fluorodeoxyuridylate study in the realm of Thymidylate synthase interacts with subjects such as Ligand binding assay.
Charles Heidelberger has included themes like Cell and In vitro in his Embryo study.
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