Daniel V. Santi spends much of his time researching Biochemistry, Stereochemistry, Thymidylate synthase, Enzyme and Molecular biology. His study in Biochemistry concentrates on Dihydrofolate reductase, Mutant, Peptide sequence, Polyketide and Gene. His Stereochemistry study incorporates themes from Covalent bond, Active site, Adduct, Cysteine and Nucleophile.
His biological study spans a wide range of topics, including Mutagenesis and Biochemical Pharmacology. His Enzyme research is multidisciplinary, relying on both Transfer RNA and DNA. His study in the field of Gel electrophoresis also crosses realms of MAP2K7.
Daniel V. Santi mainly investigates Biochemistry, Stereochemistry, Thymidylate synthase, Enzyme and Molecular biology. His is involved in several facets of Biochemistry study, as is seen by his studies on Escherichia coli, Dihydrofolate reductase, Transfer RNA, Gene and Mutant. His work is dedicated to discovering how Stereochemistry, Covalent bond are connected with Nucleophile and other disciplines.
His Thymidylate synthase study combines topics from a wide range of disciplines, such as Lactobacillus casei, Catalysis, Deoxyuridine and Ternary complex. His Enzyme research incorporates elements of Moiety, Methyltransferase and Binding site. The Molecular biology study combines topics in areas such as Heterologous expression, DNA and Expression vector.
Daniel V. Santi mostly deals with Combinatorial chemistry, Prodrug, Drug delivery, Pharmacology and Pharmacokinetics. He interconnects Stereochemistry and Drug in the investigation of issues within Prodrug. The concepts of his Self-healing hydrogels study are interwoven with issues in Somatostatin, Biodegradation, Polymer and Biochemistry.
His Biochemistry research is multidisciplinary, incorporating perspectives in Computational biology and Rational design. His Leishmania tropica study combines topics in areas such as Thymidylate synthase and Molecular biology. Thymidylate synthase is frequently linked to DNA in his study.
His primary areas of investigation include Combinatorial chemistry, Prodrug, Drug, Self-healing hydrogels and Drug delivery. His study in Prodrug is interdisciplinary in nature, drawing from both Macromolecule, Drug release, Controlled release, Stereochemistry and In vivo. His Stereochemistry research incorporates themes from Transferase, Binding site, Hypothemycin and Cytotoxicity.
His study looks at the relationship between Drug and fields such as Covalent bond, as well as how they intersect with chemical problems. His Methyl group study frequently links to adjacent areas such as Biochemistry. He is interested in Yeast, which is a branch of Biochemistry.
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The Catalytic Mechanism and Structure of Thymidylate Synthase
Christopher W. Carreras;Daniel V. Santi.
Annual Review of Biochemistry (1995)
Ribosomal RNA sequence shows Pneumocystis carinii to be a member of the Fungi
Jeffrey C. Edman;Joseph A. Kovacs;Henry Masur;Daniel V. Santi.
Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate.
Daniel V. Santi;Charles S. McHenry;Hans Sommer.
Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine
Daniel V. Santi;Anne Norment;Charles E. Garrett.
Proceedings of the National Academy of Sciences of the United States of America (1984)
On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs.
Daniel V. Santi;Charles E. Garrett;Philip J. Barr.
Kinetic and catalytic mechanism of HhaI methyltransferase.
John C. Wu;Daniel V. Santi.
Journal of Biological Chemistry (1987)
Structure-based discovery of inhibitors of thymidylate synthase
Brian K. Shoichet;Robert M. Stroud;Daniel V. Santi;Irwin D. Kuntz.
A Model of Structure and Catalysis for Ketoreductase Domains in Modular Polyketide Synthases
Ralph Reid;Misty Piagentini;Eduardo Rodriguez;Gary Ashley.
Atomic structure of thymidylate synthase: target for rational drug design
Larry W. Hardy;Janet S. Finer-Moore;William R. Montfort;Melvin O. Jones.
ANTIFOLATE-RESISTANT MUTANTS OF PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE
Worachart Sirawaraporn;Tanajit Sathitkul;Rachada Sirawaraporn;Yongyuth Yuthavong.
Proceedings of the National Academy of Sciences of the United States of America (1997)
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