D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Chemistry D-index 76 Citations 20,219 358 World Ranking 2478 National Ranking 929
Biology and Biochemistry D-index 81 Citations 23,122 364 World Ranking 2435 National Ranking 1316

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • DNA
  • Gene

Daniel V. Santi spends much of his time researching Biochemistry, Stereochemistry, Thymidylate synthase, Enzyme and Molecular biology. His study in Biochemistry concentrates on Dihydrofolate reductase, Mutant, Peptide sequence, Polyketide and Gene. His Stereochemistry study incorporates themes from Covalent bond, Active site, Adduct, Cysteine and Nucleophile.

His biological study spans a wide range of topics, including Mutagenesis and Biochemical Pharmacology. His Enzyme research is multidisciplinary, relying on both Transfer RNA and DNA. His study in the field of Gel electrophoresis also crosses realms of MAP2K7.

His most cited work include:

  • Ribosomal RNA sequence shows Pneumocystis carinii to be a member of the Fungi (606 citations)
  • The Catalytic Mechanism and Structure of Thymidylate Synthase (598 citations)
  • Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate. (528 citations)

What are the main themes of his work throughout his whole career to date?

Daniel V. Santi mainly investigates Biochemistry, Stereochemistry, Thymidylate synthase, Enzyme and Molecular biology. His is involved in several facets of Biochemistry study, as is seen by his studies on Escherichia coli, Dihydrofolate reductase, Transfer RNA, Gene and Mutant. His work is dedicated to discovering how Stereochemistry, Covalent bond are connected with Nucleophile and other disciplines.

His Thymidylate synthase study combines topics from a wide range of disciplines, such as Lactobacillus casei, Catalysis, Deoxyuridine and Ternary complex. His Enzyme research incorporates elements of Moiety, Methyltransferase and Binding site. The Molecular biology study combines topics in areas such as Heterologous expression, DNA and Expression vector.

He most often published in these fields:

  • Biochemistry (46.25%)
  • Stereochemistry (33.17%)
  • Thymidylate synthase (27.12%)

What were the highlights of his more recent work (between 2006-2021)?

  • Combinatorial chemistry (7.26%)
  • Prodrug (3.63%)
  • Drug delivery (3.39%)

In recent papers he was focusing on the following fields of study:

Daniel V. Santi mostly deals with Combinatorial chemistry, Prodrug, Drug delivery, Pharmacology and Pharmacokinetics. He interconnects Stereochemistry and Drug in the investigation of issues within Prodrug. The concepts of his Self-healing hydrogels study are interwoven with issues in Somatostatin, Biodegradation, Polymer and Biochemistry.

His Biochemistry research is multidisciplinary, incorporating perspectives in Computational biology and Rational design. His Leishmania tropica study combines topics in areas such as Thymidylate synthase and Molecular biology. Thymidylate synthase is frequently linked to DNA in his study.

Between 2006 and 2021, his most popular works were:

  • Synthesis of methyl halides from biomass using engineered microbes. (198 citations)
  • Hydrogel drug delivery system with predictable and tunable drug release and degradation rates (193 citations)
  • Long-term stabilization of maleimide-thiol conjugates. (173 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • DNA
  • Gene

His primary areas of investigation include Combinatorial chemistry, Prodrug, Drug, Self-healing hydrogels and Drug delivery. His study in Prodrug is interdisciplinary in nature, drawing from both Macromolecule, Drug release, Controlled release, Stereochemistry and In vivo. His Stereochemistry research incorporates themes from Transferase, Binding site, Hypothemycin and Cytotoxicity.

His study looks at the relationship between Drug and fields such as Covalent bond, as well as how they intersect with chemical problems. His Methyl group study frequently links to adjacent areas such as Biochemistry. He is interested in Yeast, which is a branch of Biochemistry.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

The Catalytic Mechanism and Structure of Thymidylate Synthase

Christopher W. Carreras;Daniel V. Santi.
Annual Review of Biochemistry (1995)

1022 Citations

Ribosomal RNA sequence shows Pneumocystis carinii to be a member of the Fungi

Jeffrey C. Edman;Joseph A. Kovacs;Henry Masur;Daniel V. Santi.
Nature (1988)

978 Citations

Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate.

Daniel V. Santi;Charles S. McHenry;Hans Sommer.
Biochemistry (1974)

840 Citations

Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine

Daniel V. Santi;Anne Norment;Charles E. Garrett.
Proceedings of the National Academy of Sciences of the United States of America (1984)

658 Citations

On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs.

Daniel V. Santi;Charles E. Garrett;Philip J. Barr.
Cell (1983)

538 Citations

Kinetic and catalytic mechanism of HhaI methyltransferase.

John C. Wu;Daniel V. Santi.
Journal of Biological Chemistry (1987)

537 Citations

Structure-based discovery of inhibitors of thymidylate synthase

Brian K. Shoichet;Robert M. Stroud;Daniel V. Santi;Irwin D. Kuntz.
Science (1993)

430 Citations

A Model of Structure and Catalysis for Ketoreductase Domains in Modular Polyketide Synthases

Ralph Reid;Misty Piagentini;Eduardo Rodriguez;Gary Ashley.
Biochemistry (2003)

426 Citations

Atomic structure of thymidylate synthase: target for rational drug design

Larry W. Hardy;Janet S. Finer-Moore;William R. Montfort;Melvin O. Jones.
Science (1987)

424 Citations

ANTIFOLATE-RESISTANT MUTANTS OF PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE

Worachart Sirawaraporn;Tanajit Sathitkul;Rachada Sirawaraporn;Yongyuth Yuthavong.
Proceedings of the National Academy of Sciences of the United States of America (1997)

400 Citations

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