World's Best Scientists 2026 revealed!

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Chemistry

D-Index
79
Citations
24008
World Ranking
3581
National Ranking
1159

Biology and Biochemistry

D-Index
84
Citations
27086
World Ranking
3295
National Ranking
1669

Overview

Daniel V. Santi is affiliated with the University of California, San Francisco in the United States. Their research primarily spans the fields of medicine as well as biochemistry, genetics, and molecular biology. Their work concentrates on several subfields, including molecular biology, oncology, immunology, biomedical engineering, and biomaterials.

Their publication record includes papers focused on cancer therapeutics, drug delivery systems, immunotherapy, and DNA repair mechanisms. Recent papers include:

  • Does sacituzumab-govitecan act as a conventional antibody drug conjugate (ADC), a prodrug of SN-38 or both?, 2021, Annals of Translational Medicine

Daniel V. Santi has collaborated frequently with other researchers with whom they have coauthored multiple publications. Some of their most frequent collaborators are Gary W. Ashley, John A. Hangasky, Shaun D. Fontaine, Eric L. Schneider, and Niranjan Meher.

The scientist's work appears regularly in several journals where they have contributed multiple publications. The top venues featuring their research include:

  • Cancer Research
  • Engineering Reports
  • Frontiers in Immunology
  • Molecular Cancer Therapeutics
  • Bioconjugate Chemistry

Daniel V. Santi's research topics cover a range of areas with a focus on therapeutic approaches and mechanisms in oncology and immunology. These topics include:

  • Cancer therapeutics and mechanisms
  • Nanoparticle-Based Drug Delivery
  • CAR-T cell therapy research
  • PARP inhibition in cancer therapy
  • DNA Repair Mechanisms
  • Immune Cell Function and Interaction
  • Nanoplatforms for cancer theranostics

Their work in the biomedical engineering and biomaterials subfields has supported investigations into improved drug delivery systems and novel therapeutic platforms. The focus on molecular biology and oncology topics indicates an interdisciplinary approach toward understanding cancer biology and treatment strategies.

Best Publications

  • Peptoids: a modular approach to drug discovery.

    R J Simon;R S Kania;R N Zuckermann;V D Huebner

  • The Catalytic Mechanism and Structure of Thymidylate Synthase

    Christopher W. Carreras;Daniel V. Santi

  • Ribosomal RNA sequence shows Pneumocystis carinii to be a member of the Fungi

    Jeffrey C. Edman;Joseph A. Kovacs;Henry Masur;Daniel V. Santi

  • Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate.

    Daniel V. Santi;Charles S. McHenry;Hans Sommer

  • Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine

    Daniel V. Santi;Anne Norment;Charles E. Garrett

  • On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs.

    Daniel V. Santi;Charles E. Garrett;Philip J. Barr

  • Kinetic and catalytic mechanism of HhaI methyltransferase.

    John C. Wu;Daniel V. Santi

  • Long-term stabilization of maleimide-thiol conjugates.

    Shaun D. Fontaine;Ralph Reid;Louise Robinson;Gary W. Ashley

  • Hydrogel drug delivery system with predictable and tunable drug release and degradation rates

    Gary W. Ashley;Jeff Henise;Ralph Reid;Daniel V. Santi

  • A Model of Structure and Catalysis for Ketoreductase Domains in Modular Polyketide Synthases

    Ralph Reid;Misty Piagentini;Eduardo Rodriguez;Gary Ashley

  • Structure-based discovery of inhibitors of thymidylate synthase

    Brian K. Shoichet;Robert M. Stroud;Daniel V. Santi;Irwin D. Kuntz

  • ANTIFOLATE-RESISTANT MUTANTS OF PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE

    Worachart Sirawaraporn;Tanajit Sathitkul;Rachada Sirawaraporn;Yongyuth Yuthavong

  • Atomic structure of thymidylate synthase: target for rational drug design

    Larry W. Hardy;Janet S. Finer-Moore;William R. Montfort;Melvin O. Jones

  • Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes

    Hugo G Menzella;Ralph Reid;John R Carney;Sunil S Chandran

  • A rapid and sensitive high pressure liquid chromatography assay for deoxyribonucleoside triphosphates in cell extracts.

    Charles Garrett;Daniel V. Santi

  • Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts

    James T. Kealey;Lu Liu;Daniel V. Santi;Mary C. Betlach

  • Total synthesis of long DNA sequences: Synthesis of a contiguous 32-kb polyketide synthase gene cluster

    Sarah J. Kodumal;Kedar G. Patel;Ralph Reid;Hugo G. Menzella

  • Unstable DNA amplifications in methotrexate-resistant Leishmania consist of extrachromosomal circles which relocalize during stabilization.

    Stephen M. Beverley;Jeffrey A. Coderre;Daniel V. Santi;Robert T. Schimke

  • Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica.

    Jeffrey A. Coderre;Stephen M. Beverley;Robert T. Schimke;Daniel V. Santi

  • Synthesis of methyl halides from biomass using engineered microbes.

    Travis S. Bayer;Daniel M. Widmaier;Karsten Temme;Ethan A. Mirsky

Frequent Co-Authors

Robert M. Stroud
Robert M. Stroud University of California, San Francisco
Chaitan Khosla
Chaitan Khosla Stanford University
Philip J. Barr
Philip J. Barr BayMedica, Inc.
Padmanabhan Balaram
Padmanabhan Balaram Indian Institute of Science
Akira Matsuda
Akira Matsuda Juntendo University
Peter V. Danenberg
Peter V. Danenberg University of Southern California
Ronald N. Zuckermann
Ronald N. Zuckermann Lawrence Berkeley National Laboratory
Irwin D. Kuntz
Irwin D. Kuntz University of California, San Francisco
Brian K. Shoichet
Brian K. Shoichet University of California, San Francisco
Leonard Katz
Leonard Katz Haskins Laboratories

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