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Molecular Biology

D-Index
50
Citations
10465
World Ranking
2555
National Ranking
5

Overview

Jan Trka is affiliated with Charles University in the Czech Republic and has a research focus spanning Medicine, Biochemistry, Genetics, and Molecular Biology. Their work covers several subfields including Public Health, Environmental and Occupational Health, Hematology, Molecular Biology, Genetics, and Pediatrics, Perinatology and Child Health.

Their research topics primarily emphasize Acute Lymphoblastic Leukemia research, Acute Myeloid Leukemia Research, and Chronic Myeloid Leukemia Treatments. Other significant areas include Childhood Cancer Survivors' Quality of Life, Chronic Lymphocytic Leukemia Research, Cancer Genomics and Diagnostics, and Lymphoma Diagnosis and Treatment.

Frequent coauthors collaborating with Jan Trka include Markéta Žaliová, Jan Starý, Jan Zuna, Eva Froňková, and Lucie Šrámková. Their publications have appeared predominantly in the journals Blood, Leukemia, HemaSphere, Haematologica, and Blood Advances.

Notable recent papers authored or coauthored by Jan Trka highlight various aspects of leukemia research:

  • "The KMT2A recombinome of acute leukemias in 2023" (2023, Leukemia)
  • "DUX4r, ZNF384r and PAX5-P80R mutated B-cell precursor acute lymphoblastic leukemia frequently undergo monocytic switch" (2020, Haematologica)
  • "Minimal residual disease in BCR::ABL1-positive acute lymphoblastic leukemia: different significance in typical ALL and in CML-like disease" (2022, Leukemia)
  • "The Gene Expression Classifier ALLCatchR Identifies B-cell Precursor ALL Subtypes and Underlying Developmental Trajectories Across Age" (2023, HemaSphere)
  • "NGS better discriminates true MRD positivity for the risk stratification of childhood ALL treated on an MRD-based protocol" (2022, Blood)

Best Publications

  • Analysis of minimal residual disease by Ig/TCR gene rearrangements: guidelines for interpretation of real-time quantitative PCR data.

    V H J van der Velden;G Cazzaniga;A Schrauder;J Hancock

  • The MLL recombinome of acute leukemias in 2017

    C Meyer;T Burmeister;D Gröger;G Tsaur

  • The MLL recombinome of acute leukemias in 2013

    C. Meyer;J. Hofmann;T. Burmeister;D. Gröger

  • New insights to the MLL recombinome of acute leukemias

    C. Meyer;E. Kowarz;J. Hofmann;A. Renneville

  • Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome

    Dani Bercovich;Ithamar Ganmore;Linda M. Scott;Gilad Wainreb

  • Intensive Chemotherapy for Childhood Acute Lymphoblastic Leukemia: Results of the Randomized Intercontinental Trial ALL IC-BFM 2002

    Jan Stary;Martin Zimmermann;Myriam Campbell;Luis Castillo

  • Standardized flow cytometry for highly sensitive MRD measurements in B-cell acute lymphoblastic leukemia

    Prisca Theunissen;Ester Mejstrikova;Lukasz Sedek;Alita J. van der Sluijs-Gelling

  • NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern.

    Iris H.I.M. Hollink;Marry M. van den Heuvel-Eibrink;Susan T.C.J.M. Arentsen-Peters;Marta Pratcorona

  • Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21.

    Liat Rainis;Dan Bercovich;Sabine Strehl;Andrea Teigler-Schlegel

  • The MLL recombinome of acute leukemias.

    C. Meyer;B. Schneider;S. Jakob;S. Strehl

  • Standardized next-generation sequencing of immunoglobulin and T-cell receptor gene recombinations for MRD marker identification in acute lymphoblastic leukaemia; a EuroClonality-NGS validation study

    Monika Brüggemann;Michaela Kotrová;Henrik Knecht;Jack Bartram

  • NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX gene expression pattern.

    J D E de Rooij;I H I M Hollink;S T C J M Arentsen-Peters;J F van Galen

  • IKZF1 status as a prognostic feature in BCR-ABL1-positive childhood ALL

    Arian van der Veer;Marketa Zaliova;Marketa Zaliova;Federica Mottadelli;Paola De Lorenzo

  • Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia.

    Iris H. I. M. Hollink;Marry M. van den Heuvel-Eibrink;Martin Zimmermann;Brian V. Balgobind

  • BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations

    Anindita Basak;Miroslava Hancarova;Jacob C. Ulirsch;Tugce B. Balci

  • Real-time quantitative PCR detection of WT1 gene expression in children with AML: prognostic significance, correlation with disease status and residual disease detection by flow cytometry.

    J Trka;M Kalinová;O Hrusák;J Zuna

  • Detectable minimal residual disease before allogeneic hematopoietic stem cell transplantation predicts extremely poor prognosis in children with acute lymphoblastic leukemia

    Lucie Sramkova;Katerina Muzikova;Eva Fronkova;Ondrej Krejci

  • Evaluation of gene expression signatures predictive of cytogenetic and molecular subtypes of pediatric acute myeloid leukemia.

    Brian V. Balgobind;Marry M. Van den Heuvel-Eibrink;Renee X. De Menezes;Dirk Reinhardt

  • Identification of germline susceptibility loci in ETV6 - RUNX1 -rearranged childhood acute lymphoblastic leukemia

    E Ellinghaus;M Stanulla;G Richter;D Ellinghaus

  • Hsa-mir-125b-2 is highly expressed in childhood ETV6/RUNX1 (TEL/AML1) leukemias and confers survival advantage to growth inhibitory signals independent of p53

    Nir Gefen;Vera Binder;Vera Binder;Marketa Zaliova;Yvonne Linka

Frequent Co-Authors

Rob Pieters
Rob Pieters Princess Máxima Center
Dirk Reinhardt
Dirk Reinhardt University of Duisburg-Essen
Martin Zimmermann
Martin Zimmermann Hannover Medical School
Marry M. van den Heuvel-Eibrink
Marry M. van den Heuvel-Eibrink University Medical Center Utrecht
Martin Stanulla
Martin Stanulla Hannover Medical School
Rolf Marschalek
Rolf Marschalek Goethe University Frankfurt
Giovanni Cazzaniga
Giovanni Cazzaniga University of Milano-Bicocca
Martin Schrappe
Martin Schrappe Kiel University
André Baruchel
André Baruchel Hôpital Robert-Debré

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