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Immunology

D-Index
72
Citations
15957
World Ranking
2245
National Ranking
88

Overview

Kelli P. A. MacDonald is affiliated with the QIMR Berghofer Medical Research Institute in Australia. Their research spans across multiple disciplines including medicine, immunology and microbiology, and biochemistry, genetics, and molecular biology. Within these broad areas, their work focuses on several subfields such as immunology, molecular biology, hematology, neurology, and hepatology.

The scientist's studies address a range of topics, including:

  • Hematopoietic Stem Cell Transplantation
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Immune cells in cancer
  • Protein Degradation and Inhibitors
  • Liver physiology and pathology

MacDonald has contributed to multiple recent publications that highlight the diversity of their research interests. Some of these papers include:

  • "Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner," 2020, published in Cell
  • "BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection," 2021, published in Cell
  • "ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis," 2021, published in JHEP Reports
  • "Toward a Better Understanding of the Atypical Features of Chronic Graft-Versus-Host Disease: A Report from the 2020 National Institutes of Health Consensus Project Task Force," 2022, published in Transplantation and Cellular Therapy
  • "National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: III. The 2020 Treatment of Chronic GVHD Report," 2021, published in Transplantation and Cellular Therapy

Frequent collaboration has been established with several co-authors, including:

  • Bruce R. Blazar
  • Geoffrey R. Hill
  • Jana Vukovic
  • Christian Engwerda
  • Robert Zeiser

The scientist's work is commonly published in prominent venues such as Blood, bioRxiv (Cold Spring Harbor Laboratory), The Journal of Immunology, Cell, and Transplantation and Cellular Therapy.

Best Publications

  • Characterization of human blood dendritic cell subsets.

    Kelli P A MacDonald;David J Munster;Georgina J Clark;Andrzej Dzionek

  • Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling

    David A Hume;Kelli P A MacDonald

  • An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation

    Kelli P. A. MacDonald;James S. Palmer;Stephen Cronau;Elke Jane Seppanen

  • Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner

    Emily F. Willis;Kelli P.A. MacDonald;Quan H. Nguyen;Adahir Labrador Garrido

  • Chronic graft-versus-host disease: biological insights from preclinical and clinical studies

    Kelli P. A. MacDonald;Geoffrey R. Hill;Geoffrey R. Hill;Bruce R. Blazar

  • Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease

    Motoko Koyama;Rachel D Kuns;Stuart D Olver;Neil C Raffelt

  • Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions

    Lynette Beattie;Lynette Beattie;Amy Sawtell;Jason L. Mann;Teija C.M. Frame

  • CSF-1–dependant donor-derived macrophages mediate chronic graft-versus-host disease

    Kylie A. Alexander;Ryan Flynn;Katie E. Lineburg;Rachel D. Kuns

  • Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

    Ryan P Flynn;Jing Du;Rachelle G. Veenstra;Dawn K Reichenbach

  • A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment

    Frederic Sierro;Maximilien Evrard;Simone Rizzetto;Michelle Melino

  • The Colony-Stimulating Factor 1 Receptor Is Expressed on Dendritic Cells during Differentiation and Regulates Their Expansion

    Kelli P A MacDonald;Vanessa Rowe;Helen M Bofinger;Ranjeny Thomas

  • Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial.

    Glen A. Kennedy;Glen A. Kennedy;Antiopi Varelias;Slavica Vuckovic;Laetitia Le Texier

  • Ibrutinib treatment ameliorates murine chronic graft-versus-host disease

    Jason A. Dubovsky;Ryan P Flynn;Jing Du;Bonnie K. Harrington

  • Expression of human DEC-205 (CD205) multilectin receptor on leukocytes.

    Masato Kato;Kylie J. McDonald;Seema Khan;Ian L. Ross

  • Functional CD40 ligand is expressed by T cells in rheumatoid arthritis.

    K. P. A. MacDonald;Y. Nishioka;P. E. Lipsky;R. Thomas

  • Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism.

    Ryan Flynn;Katelyn Paz;Jing Du;Dawn K. Reichenbach

  • BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection.

    Richard J. Mills;Sean J. Humphrey;Patrick R.J. Fortuna;Mary Lor

  • The biology of graft-versus-host disease: experimental systems instructing clinical practice

    Kate A. Markey;Kate A. Markey;Kelli P. A. MacDonald;Geoffrey R. Hill;Geoffrey R. Hill

  • Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma

    Geoffrey R. Hill;Stuart D. Olver;Rachel D. Kuns;Antiopi Varelias

  • NKT cell–dependent leukemia eradication following stem cell mobilization with potent G-CSF analogs

    Edward S. Morris;Edward S. Morris;Kelli P.A. MacDonald;Vanessa Rowe;Tatjana Banovic

  • Host B cells produce IL-10 following TBI and attenuate acute GVHD after allogeneic bone marrow transplantation.

    Vanessa Rowe;Tatjana Banovic;Tatjana Banovic;Kelli P. MacDonald;Kelli P. MacDonald;Rachel Kuns;Rachel Kuns

Frequent Co-Authors

Geoffrey R. Hill
Geoffrey R. Hill Fred Hutchinson Cancer Research Center
Andrew D. Clouston
Andrew D. Clouston University of Queensland
Bruce R. Blazar
Bruce R. Blazar University of Minnesota
Mark J. Smyth
Mark J. Smyth QIMR Berghofer Medical Research Institute
Christian R. Engwerda
Christian R. Engwerda QIMR Berghofer Medical Research Institute
Ranjeny Thomas
Ranjeny Thomas University of Queensland
Jonathan S. Serody
Jonathan S. Serody University of North Carolina at Chapel Hill
Ivan Maillard
Ivan Maillard University of Pennsylvania
Angela Panoskaltsis-Mortari
Angela Panoskaltsis-Mortari University of Minnesota
Leo Luznik
Leo Luznik Johns Hopkins University

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