World's Best Scientists 2026 revealed!
Award Badge
Medicine
Netherlands
2023

D-Index & Metrics

Medicine

D-Index
144
Citations
76742
World Ranking
1445
National Ranking
48

Research.com Recognitions

  • 2023 - Research.com Medicine in Netherlands Leader Award

Overview

E. Ronald de Kloet is affiliated with Leiden University Medical Center in the Netherlands. Their research primarily spans the fields of Neuroscience and Medicine, with a notable focus on Behavioral Neuroscience, Endocrinology, Diabetes and Metabolism, Social Psychology, Clinical Psychology, and Biological Psychiatry.

Their scientific investigations concentrate on several main topics, including:

  • Stress Responses and Cortisol
  • Hormonal Regulation and Hypertension
  • Neuroendocrine regulation and behavior
  • Tryptophan and brain disorders
  • Circadian rhythm and melatonin
  • Maternal Mental Health During Pregnancy and Postpartum
  • Child and Adolescent Psychosocial and Emotional Development

The research output of E. Ronald de Kloet is published across various specialized venues. Frequent publication outlets include:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Psychoneuroendocrinology
  • Archives of Veterinary Science and Medicine
  • Molecular Neurobiology
  • Molecular Psychiatry

Among recent papers featuring de Kloet's work are:

  • "The cortisol switch between vulnerability and resilience," 2023, Molecular Psychiatry
  • "Forced swim stressor: Trends in usage and mechanistic consideration," 2021, European Journal of Neuroscience
  • "Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress," 2020, Scientific Reports
  • "Mineralocorticoid receptor and glucocorticoid receptor work alone and together in cell-type-specific manner: Implications for resilience prediction and targeted therapy," 2022, Neurobiology of Stress
  • "Insights into the Therapeutic Potential of Glucocorticoid Receptor Modulators for Neurodegenerative Diseases," 2020, International Journal of Molecular Sciences

The scientist has collaborated frequently with several coauthors, including:

  • Onno C. Meijer
  • Marc Molendijk
  • Alejandro F. De Nicola
  • María Meyer
  • Megan Galbally

The scope of their work reflects an interdisciplinary approach combining elements of stress physiology, neuroendocrinology, and psychological processes with molecular and cellular insights. This body of research contributes to understanding the complex mechanisms underlying stress vulnerability, resilience, and hormonal regulation.

Best Publications

  • Stress and the brain: from adaptation to disease

    E. Ron de Kloet;Marian Joëls;Florian Holsboer

  • Brain corticosteroid receptor balance in health and disease.

    E R De Kloet;E Vreugdenhil;M S Oitzl;M Joëls

  • Two Receptor Systems for Corticosterone in Rat Brain: Microdistribution and Differential Occupation

    J. M. H. M. Reul;E. R. De Kloet

  • Stress and cognition: are corticosteroids good or bad guys?

    E. Ron de Kloet;Melly S. Oitzl;Marian Joëls

  • Adrenal steroid receptors and actions in the nervous system

    B. S. McEwen;E. R. De Kloet;W. Rostene

  • LOCALISATION OF 11β-HYDROXYSTEROID DEHYDROGENASE—TISSUE SPECIFIC PROTECTOR OF THE MINERALOCORTICOID RECEPTOR

    C.R.W. Edwards;D. Burt;M.A. Mcintyre;E.R. De Kloet

  • Feedback action and tonic influence of corticosteroids on brain function: a concept arising from the heterogeneity of brain receptor systems

    E.R. De Kloet;J.M.H.M. Reul

  • The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome.

    Nikolaos P. Daskalakis;Nikolaos P. Daskalakis;Nikolaos P. Daskalakis;Rosemary C. Bagot;Rosemary C. Bagot;Karen J. Parker;Christiaan H. Vinkers

  • Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress

    Danielle L. Champagne;Rosemary C. Bagot;Felisa van Hasselt;Ger Ramakers

  • Differences in corticosterone and dexamethasone binding to rat brain and pituitary

    Ronald De Kloet;Gislaine Wallach;Bruce S. McEWEN

  • On the role of brain mineralocorticoid (type I) and glucocorticoid (type II) receptors in neuroendocrine regulation.

    Anna Ratka;Winardi Sutanto;Margreet Bloemers;Ronald de Kloet

  • The coming out of the brain mineralocorticoid receptor

    Marian Joëls;Henk Karst;Roel DeRijk;E. Ronald de Kloet

  • Do corticosteroids damage the brain

    J. Herbert;I. M. Goodyer;A. B. Grossman;M. H. Hastings

  • Control of neuronal excitability by corticosteroid hormones.

    Marian Joëls;E.Ronald de Kloet

  • Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems

    M. Joëls;E.R. de Kloet

  • Corticosteroid hormones in the central stress response: quick-and-slow.

    E. Ronald de Kloet;Henk Karst;Marian Joëls

  • The influence of ovarian steroids on hypothalamic-pituitary-adrenal regulation in the female rat.

    M P Carey;C H Deterd;J de Koning;F Helmerhorst

  • Altered reactivity of the hypothalamic-pituitary-adrenal axis in the primary fibromyalgia syndrome.

    E N Griep;J W Boersma;E R de Kloet

  • Cellular Localization of Interleukin 6 mRNA and Interleukin 6 Receptor mRNA in Rat Brain

    B. Schöbitz;E. R. de Kloet;W. Sutanto;F. Holsboer

  • Stress, genes and the mechanism of programming the brain for later life.

    E. Ronald de Kloet;Rosana M. Sibug;Frans M. Helmerhorst;Mathias Schmidt

Frequent Co-Authors

Melly S. Oitzl
Melly S. Oitzl University of Amsterdam
Onno C. Meijer
Onno C. Meijer Leiden University Medical Center
Marian Joëls
Marian Joëls University of Groningen
Alejandro F. De Nicola
Alejandro F. De Nicola University of Buenos Aires
Dirk H.G. Versteeg
Dirk H.G. Versteeg Utrecht University
Béla Bohus
Béla Bohus University of Groningen
Mathias V. Schmidt
Mathias V. Schmidt Max Planck Society
Henk Karst
Henk Karst Utrecht University
Seymour Levine
Seymour Levine Stanford University
Frans G. Zitman
Frans G. Zitman Leiden University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Considering a career in medicine doesn’t have to follow a traditional MD track. There are a variety of related online degrees and alternative routes in the healthcare field, each offering different specializations and career opportunities.

If you’re interested in mental health and nursing, the fastest psych np program options allow registered nurses to quickly advance and become Psychiatric Mental Health Nurse Practitioners. This path offers a flexible and in-demand career choice, especially for those passionate about mental wellness.

For those looking to move into the business side of healthcare, pursuing an online degree in healthcare administration can open doors. The healthcare administration degrees are designed for aspiring leaders who want to manage health services or facilities. There are even cheap mha programs that provide a cost-effective route to a Master’s in Healthcare Administration.

Additionally, professionals seeking the highest level of nursing education should consider the best online dnp programs. These Doctor of Nursing Practice programs help nurses move into critical leadership, policy, or advanced clinical roles.

Best Scientists Citing E. Ronald de Kloet

Trending Scientists