World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
60
Citations
17888
World Ranking
1934
National Ranking
961

Overview

Brian L. Black is affiliated with the University of California, San Francisco in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with significant contributions also in Medicine. Within these broader fields, their work focuses on subfields such as Molecular Biology, Surgery, Pulmonary and Respiratory Medicine, Cancer Research, and Epidemiology.

The scientist's research topics cover a range of areas including Congenital heart defects research, RNA modifications and cancer, RNA research and splicing, single-cell and spatial transcriptomics, epigenetics and DNA methylation, congenital heart disease studies, and RNA and protein synthesis mechanisms.

Brian L. Black has contributed numerous publications, with some frequently appearing venues including bioRxiv (Cold Spring Harbor Laboratory), The American Journal of Gastroenterology, Circulation Research, Circulation, and Cell Reports.

Recent representative papers include:

  • Comprehensive cell type decomposition of circulating cell-free DNA with CelFiE, 2021, Nature Communications
  • Transcription factor protein interactomes reveal genetic determinants in heart disease, 2022, Cell
  • ATAC-Seq Reveals an Isl1 Enhancer That Regulates Sinoatrial Node Development and Function, 2020, Circulation Research
  • An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair, 2022, Cell stem cell
  • Presynaptic Homeostasis Opposes Disease Progression in Mouse Models of ALS-Like Degeneration: Evidence for Homeostatic Neuroprotection, 2020, Neuron

Frequent coauthors collaborating with Brian L. Black include:

  • Tanvi Sinha
  • Benoit G. Bruneau
  • Deepak Srivastava
  • Barbara Celona
  • Reuben Thomas

Best Publications

  • TRANSCRIPTIONAL CONTROL OF MUSCLE DEVELOPMENT BY MYOCYTE ENHANCER FACTOR-2 (MEF2) PROTEINS

    Brian L. Black;Eric N. Olson

  • In vivo enhancer analysis of human conserved non-coding sequences

    Len A. Pennacchio;Len A. Pennacchio;Nadav Ahituv;Alan M. Moses;Shyam Prabhakar

  • Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins

    Jeffery D. Molkentin;Brian L. Black;James F. Martin;Eric N. Olson

  • Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

    Stephen C. J. Parker;Michael L. Stitzel;D. Leland Taylor;Jose Miguel Orozco

  • An Nkx2-5/Bmp2/Smad1 Negative Feedback Loop Controls Heart Progenitor Specification and Proliferation

    Owen W.J. Prall;Mary K. Menon;Mark J. Solloway;Yusuke Watanabe

  • The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary/anterior heart field

    Michael P. Verzi;David J. McCulley;Sarah De Val;Evdokia Dodou

  • TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3.

    Dong Liu;Brian L. Black;Rik Derynck

  • ChIP-Seq identification of weakly conserved heart enhancers

    Matthew J Blow;David J McCulley;Zirong Li;Tao Zhang

  • Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development

    Evdokia Dodou;Michael P. Verzi;Joshua P. Anderson;Shan-Mei Xu

  • Transcriptional Control of Endothelial Cell Development

    Sarah De Val;Brian L. Black

  • Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor

    Francisco J. Naya;Brian L. Black;Hai Wu;Rhonda S Bassel-Duby

  • Foxn4 directly regulates tbx2b expression and atrioventricular canal formation

    Neil C. Chi;Robin M. Shaw;Sarah De Val;Guson Kang

  • Combinatorial regulation of endothelial gene expression by ets and forkhead transcription factors

    Sarah De Val;Neil C. Chi;Stryder M. Meadows;Simon Minovitsky

  • Transcription Factor Pathways and Congenital Heart Disease

    David J. McCulley;Brian L. Black

  • Required, Tissue-Specific Roles for Fgf8 in Outflow Tract Formation and Remodeling

    Eon Joo Park;Lisa A. Ogden;Amy Talbot;Sylvia Evans

  • Large-scale discovery of enhancers from human heart tissue

    Dalit May;Matthew J Blow;Matthew J Blow;Tommy Kaplan;Tommy Kaplan;David J McCulley

  • Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development

    Jun K. Takeuchi;Maria Mileikovskaia;Kazuko Koshiba-Takeuchi;Analeah B. Heidt

  • Modulation of tissue repair by regeneration enhancer elements

    Junsu Kang;Jianxin Hu;Ravi Karra;Amy L. Dickson

  • Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation.

    Fiona A Stennard;Mauro W Costa;Mauro W Costa;Donna Lai;Christine Biben

  • Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C.

    Jeffery D. Molkentin;Brian L. Black;James F. Martin;Eric N. Olson

Frequent Co-Authors

Len A. Pennacchio
Len A. Pennacchio Lawrence Berkeley National Laboratory
Eric N. Olson
Eric N. Olson The University of Texas Southwestern Medical Center
Benoit G. Bruneau
Benoit G. Bruneau Gladstone Institutes
Axel Visel
Axel Visel Lawrence Berkeley National Laboratory
Jeffery D. Molkentin
Jeffery D. Molkentin Cincinnati Children's Hospital Medical Center
James F. Martin
James F. Martin Baylor College of Medicine
Didier Y. R. Stainier
Didier Y. R. Stainier Max Planck Society
Edward M. Rubin
Edward M. Rubin Joint Genome Institute
Nevan J. Krogan
Nevan J. Krogan University of California, San Francisco
Deepak Srivastava
Deepak Srivastava King's College London

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