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Overview

Douglas S. Lyles is affiliated with Wake Forest University in the United States. Their research primarily focuses on virus-based gene therapy, bacteriophages and microbial interactions, virology and viral diseases, RNA research and splicing, and viral infections and outbreaks research. The scientist's work spans the fields of biochemistry, genetics and molecular biology, as well as medicine.

Within these broad fields, their subfield expertise includes genetics, epidemiology, ecology, molecular biology, and immunology. The main topics addressed in their work are virus-based gene therapy research, bacteriophages and microbial interactions, virology and viral diseases, RNA research and splicing, viral infections and outbreaks research, interferon and immune responses, and animal virus infections studies.

Douglas S. Lyles has been involved in multiple recent publications, contributing to the study of vesicular stomatitis virus and related viral mechanisms. Notable recent papers include:

  • MAP3K7 and CHD1 Are Novel Mediators of Resistance to Oncolytic Vesicular Stomatitis Virus in Prostate Cancer Cells, 2020, Molecular Therapy - Oncolytics
  • Vesicular stomatitis virus nucleocapsids diffuse through cytoplasm by hopping from trap to trap in random directions, 2020, Scientific Reports
  • Diversity in responses to oncolytic Lassa-vesicular stomatitis virus in patient-derived glioblastoma cells, 2021, Molecular Therapy - Oncolytics
  • Dynamic Actin Filament Traps Mediate Active Diffusion of Vesicular Stomatitis Virus Ribonucleoproteins, 2022, Journal of Virology
  • Mechanisms of active diffusion of vesicular stomatitis virus inclusion bodies and cellular early endosomes in the cytoplasm of mammalian cells, 2024, PLoS ONE

The venues in which they have published frequently include:

  • Molecular Therapy - Oncolytics (3 publications)
  • Biophysical Journal (2 publications)
  • Scientific Reports (1 publication)
  • Journal of Virology (1 publication)
  • PLoS ONE (1 publication)

Lyles has collaborated often with a group of co-authors including G. Holzwarth, Jed C. Macosko, David A. Ornelles, Steven J. Moran, and Shelby Puckett. These frequent collaborators have contributed to the development of the scientific themes and findings presented in their joint research.

Best Publications

  • The interaction of antibody with the major surface glycoprotein of vesicular stomatitis virus I. Analysis of neutralizing epitopes with monoclonal antibodies

    Leo Lefrancois;Douglas S. Lyles

  • Ability of the Matrix Protein of Vesicular Stomatitis Virus To Suppress Beta Interferon Gene Expression Is Genetically Correlated with the Inhibition of Host RNA and Protein Synthesis

    Maryam Ahmed;Margie O. McKenzie;Shelby Puckett;Michael Hojnacki

  • Cytopathogenesis and Inhibition of Host Gene Expression by RNA Viruses

    Douglas S. Lyles

  • Matrix Protein and Another Viral Component Contribute to Induction of Apoptosis in Cells Infected with Vesicular Stomatitis Virus

    Sarah A. Kopecky;Mark C. Willingham;Douglas S. Lyles

  • Vesicular Stomatitis Virus Infection Alters the eIF4F Translation Initiation Complex and Causes Dephosphorylation of the eIF4E Binding Protein 4E-BP1

    John H. Connor;Douglas S. Lyles

  • The interaction of antibody with the major surface glycoprotein of vesicular stornatitis virus II. Monoclonal antibodies to nonneutralizing and cross-reactive epitopes of Indiana and New Jersey serotypes☆

    Leo Lefrancois;Douglas S. Lyles

  • Vesicular stomatitis virus matrix protein inhibits host cell-directed transcription of target genes in vivo.

    B L Black;D S Lyles

  • Sensitivity of prostate tumors to wild type and M protein mutant vesicular stomatitis viruses.

    Maryam Ahmed;Scott D. Cramer;Douglas S. Lyles

  • Recognition of cloned vesicular stomatitis virus internal and external gene products by cytotoxic T lymphocytes.

    J W Yewdell;J R Bennink;M Mackett;L Lefrancois

  • Vesicular Stomatitis Viruses Expressing Wild-Type or Mutant M Proteins Activate Apoptosis through Distinct Pathways

    Daniel F. Gaddy;Douglas S. Lyles

  • Effect of vesicular stomatitis virus matrix protein on transcription directed by host RNA polymerases I, II, and III.

    Maryam Ahmed;Douglas S. Lyles

  • Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand viruses.

    John H. Connor;Margie O. McKenzie;Griffith D. Parks;Douglas S. Lyles

  • Mitochondria in eosinophils: Functional role in apoptosis but not respiration

    Kristina K. Peachman;Douglas S. Lyles;David A. Bass

  • The role of vesicular stomatitis virus matrix protein in inhibition of host-directed gene expression is genetically separable from its function in virus assembly.

    B L Black;R B Rhodes;M McKenzie;D S Lyles

  • Interplay between Innate Immunity and Negative-Strand RNA Viruses: towards a Rational Model

    Denis Gerlier;Douglas S. Lyles

  • Inhibition of neutrophil lysosome-phagosome fusion associated with influenza virus infection in vitro. Role in depressed bactericidal activity.

    Jon S. Abramson;Jon C. Lewis;Douglas S. Lyles;Kelley A. Heller

  • Contrasting Effects of Matrix Protein on Apoptosis in HeLa and BHK Cells Infected with Vesicular Stomatitis Virus Are due to Inhibition of Host Gene Expression

    Sarah A. Kopecky;Douglas S. Lyles

  • Structural Determination of Lipid-bound ApoA-I Using Fluorescence Resonance Energy Transfer

    Hui-hua Li;Douglas S. Lyles;Michael J. Thomas;Wei Pan

  • Inhibition of host and viral translation during vesicular stomatitis virus infection. eIF2 is responsible for the inhibition of viral but not host translation.

    John H. Connor;Douglas S. Lyles

  • Subunit interactions of vesicular stomatitis virus envelope glycoprotein stabilized by binding to viral matrix protein.

    D S Lyles;M McKenzie;J W Parce

  • Inhibition of host RNA polymerase II-dependent transcription by vesicular stomatitis virus results from inactivation of TFIID.

    Hang Yuan;Barbara K. Yoza;Douglas S. Lyles

  • ApoA-I structure on discs and spheres. Variable helix registry and conformational states.

    Hui-hua Li;Douglas S. Lyles;Wei Pan;Eric Alexander

Frequent Co-Authors

David A. Bass
David A. Bass Wake Forest University
Mark C. Willingham
Mark C. Willingham Wake Forest University
Michael J. Thomas
Michael J. Thomas Medical College of Wisconsin
Barry I. Freedman
Barry I. Freedman Wake Forest University
Carl D. Langefeld
Carl D. Langefeld Wake Forest University
Karl Skorecki
Karl Skorecki Technion – Israel Institute of Technology
Mark Krystal
Mark Krystal ViiV Healthcare (United Kingdom)
Peter Palese
Peter Palese Icahn School of Medicine at Mount Sinai
Steven B. Mizel
Steven B. Mizel Wake Forest University
Matthias J. Schnell
Matthias J. Schnell Thomas Jefferson University

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