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Chaim M. Roifman

Chaim M. Roifman

D-Index & Metrics

Immunology

D-Index
82
Citations
22283
World Ranking
1517
National Ranking
27

Overview

Chaim M. Roifman is affiliated with the University of Toronto in Canada and has contributed extensively to the fields of Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Their research spans multiple subfields including Immunology, Genetics, Infectious Diseases, Hematology, and Molecular Biology.

Roifman's work frequently addresses topics such as Immunodeficiency and Autoimmune Disorders, Immune Cell Function and Interaction, T-cell and B-cell Immunology, as well as SARS-CoV-2 and COVID-19 related research, including clinical studies. The research also touches on NF-κB Signaling Pathways and interferon and immune responses.

They have published in a variety of scientific venues, with a concentration of publications in LymphoSign Journal, Journal of Allergy and Clinical Immunology, npj Genomic Medicine, Frontiers in Immunology, and Clinical Immunology.

Among Roifman's recent papers are:

  • "Characterization of the clinical and immunologic phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations" (2020, Journal of Allergy and Clinical Immunology)
  • "Prevalence and Clinical Features of Inflammatory Bowel Diseases Associated With Monogenic Variants, Identified by Whole-Exome Sequencing in 1000 Children at a Single Center" (2020, Gastroenterology)
  • "Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns" (2021, Nucleic Acids Research)
  • "STAT1 gain-of-function heterozygous cell models reveal diverse interferon-signature gene transcriptional responses" (2021, npj Genomic Medicine)
  • "Combined immunodeficiency caused by a novel homozygous NFKB1 mutation" (2020, Journal of Allergy and Clinical Immunology)

Roifman has collaborated frequently with several co-authors, including Linda Vong, Ori Scott, Daniele Merico, Laura Abrego Fuentes, and Jenny Garkaby.

Best Publications

  • Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

    N Meydan;T Grunberger;H Dadi;M Shahar

  • Defective T cell receptor signaling and CD8+ thymic selection in humans lacking Zap-70 kinase

    Enrico Arpaia;Michal Shahar;Harjit Dadi;Amos Cohen

  • Primary Immunodeficiency Diseases: An Update on the Classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency

    Waleed Al-Herz;Aziz Bousfiha;Jean-Laurent Casanova;Jean-Laurent Casanova;Helen Chapel

  • Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I

    Anne Puel;Anne Puel;Rainer Döffinger;Angels Natividad;Angels Natividad;Maya Chrabieh;Maya Chrabieh

  • Primary immunodeficiencies: 2009 update

    Luigi D. Notarangelo;Alain Fischer;Raif S. Geha;Jean-Laurent Casanova

  • Primary immunodeficiency diseases: An update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee

    Raif S. Geha;Luigi D. Notarangelo;Jean Laurent Casanova;Helen Chapel

  • Human immune disorder arising from mutation of the α chain of the interleukin-2 receptor

    Nigel Sharfe;Harjit K. Dadi;Michal Shahar;Chaim M. Roifman

  • Mutations in STAT3 and IL12RB1 impair the development of human IL-17–producing T cells

    Ludovic de Beaucoudrey;Ludovic de Beaucoudrey;Anne Puel;Anne Puel;Orchidée Filipe-Santos;Orchidée Filipe-Santos;Aurélie Cobat;Aurélie Cobat

  • Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency

    Capucine Picard;Capucine Picard;Horst Von Bernuth;Horst Von Bernuth;Horst Von Bernuth;Pegah Ghandil;Pegah Ghandil;Pegah Ghandil;Maya Chrabieh;Maya Chrabieh

  • Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity

    Cheng Lung Ku;Horst Von Bernuth;Horst Von Bernuth;Capucine Picard;Shen Ying Zhang

  • Human TLR-7-, -8-, and -9-Mediated Induction of IFN-α/β and -λ Is IRAK-4 Dependent and Redundant for Protective Immunity to Viruses

    Kun Yang;Kun Yang;Anne Puel;Shenying Zhang;Shenying Zhang;Céline Eidenschenk

  • Omenn syndrome: inflammation in leaky severe combined immunodeficiency.

    Anna Villa;Luigi D. Notarangelo;Chaim M. Roifman

  • Primary immunodeficiency diseases: An update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee Meeting in Budapest, 2005

    Luigi Notarangelo;Jean-Laurent Casanova;Mary Ellen Conley;Helen Chapel

  • IL-10R polymorphisms are associated with very-early-onset ulcerative colitis

    Christopher J. Moran;Christopher J. Moran;Thomas D. Walters;Cong‐Hui Guo;Subra Kugathasan

  • Bone marrow transplantation for severe combined immune deficiency.

    Eyal Grunebaum;Evelina Mazzolari;Fulvio Porta;Daniela Dallera

  • Effect of CD3δ Deficiency on Maturation of α/β and γ/δ T-Cell Lineages in Severe Combined Immunodeficiency

    Harjit K. Dadi;Amos J. Simon;Chaim M. Roifman

  • Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature.

    Tracy A. Briggs;Gillian I. Rice;Sarah Daly;Jill Urquhart

  • Health-related quality of life and treatment satisfaction in North American patients with primary immunedeficiency diseases receiving subcutaneous IgG self-infusions at home

    Uwe Nicolay;Peter Kiessling;Melvin Berger;Sudhir Gupta

  • A partial deficiency of interleukin-7Rα is sufficient to abrogate T-cell development and cause severe combined immunodeficiency

    Chaim M. Roifman;Junyan Zhang;David Chitayat;Nigel Sharfe

  • Increased susceptibility to mycoplasma infection in patients with hypogammaglobulinemia

    Chaim M. Roifman;C. Pandu Rao;Howard M. Lederman;Sasson Lavi

  • IL-2 receptor alpha deficiency and features of primary biliary cirrhosis.

    Christopher A Aoki;Chaim M Roifman;Zhe-Xiong Lian;Christopher L Bowlus

Frequent Co-Authors

Luigi D. Notarangelo
Luigi D. Notarangelo National Institutes of Health
Erwin W. Gelfand
Erwin W. Gelfand University of Colorado Anschutz Medical Campus
Mary Ellen Conley
Mary Ellen Conley Rockefeller University
Jean-Laurent Casanova
Jean-Laurent Casanova The University of Texas Southwestern Medical Center
Daniele Merico
Daniele Merico University of Toronto
Jennifer M. Puck
Jennifer M. Puck University of California, San Francisco
Hans D. Ochs
Hans D. Ochs University of Washington
Gordon B. Mills
Gordon B. Mills Oregon Health & Science University
Rebecca H. Buckley
Rebecca H. Buckley Duke University
Anne M. Griffiths
Anne M. Griffiths University of Toronto

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