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Neuroscience

D-Index
47
Citations
10907
World Ranking
6349
National Ranking
178

Overview

Henk Karst is affiliated with Utrecht University in the Netherlands. Their research spans key areas in neuroscience, medicine, and molecular biology, indicating a multidisciplinary approach to biological and neurological sciences.

Karst's primary fields of study include:

  • Neuroscience
  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these fields, they focus on several subfields, with particular attention to behavioral and cellular neuroscience, molecular biology, social psychology, and neurology. These subfields indicate a comprehensive engagement with both the molecular mechanisms and behavioral outcomes of neurological processes.

Research topics covered by Karst highlight areas such as:

  • Stress Responses and Cortisol
  • Neuroendocrine regulation and behavior
  • Neuroscience and Neuropharmacology Research
  • Hormonal Regulation and Hypertension
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Amyotrophic Lateral Sclerosis Research
  • Genetic Neurodegenerative Diseases

Karst has contributed to several recent publications, all reflecting aspects of neuroendocrinology, neuropharmacology, and neuroscience:

  • Non-genomic steroid signaling through the mineralocorticoid receptor: Involvement of a membrane-associated receptor? (2021), Molecular and Cellular Endocrinology
  • Age-dependent shift in spontaneous excitation-inhibition balance of infralimbic prefrontal layer II/III neurons is accelerated by early life stress, independent of forebrain mineralocorticoid receptor expression (2020), Neuropharmacology
  • Acceleration of GABA-switch after early life stress changes mouse prefrontal glutamatergic transmission (2023), Neuropharmacology

Although Karst is not the first author on all papers encountered in their network, such as the 2024 Nature Communications paper on ATAXIN-2 intermediate-length polyglutamine expansions impacting ALS-related metabolic and immune phenotypes, these works are connected to their research environment.

Frequent co-authors of Karst include:

  • Marian Joëls
  • Oliver Harschnitz
  • Sandra Kling
  • Suzy Varderidou-Minasian
  • R. Jeroen Pasterkamp

Their work has appeared multiple times in specialized venues such as:

  • Neuropharmacology
  • Nature Communications
  • Molecular and Cellular Endocrinology
  • ACS Omega
  • Frontiers in Neuroendocrinology

Best Publications

  • Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone

    Henk Karst;Stefan Berger;Marc Turiault;Francois Tronche

  • The course of paraventricular hypothalamic efferents to autonomic structures in medulla and spinal cord

    P.G.M. Luiten;ter Gert Horst;H. Karst;A.B. Steffens

  • Microglia innately develop within cerebral organoids.

    Paul R. Ormel;Renata Vieira de Sá;Emma J. van Bodegraven;Henk Karst

  • The coming out of the brain mineralocorticoid receptor

    Marian Joëls;Henk Karst;Roel DeRijk;E. Ronald de Kloet

  • Unraveling the time domains of corticosteroid hormone influences on brain activity: rapid, slow, and chronic modes.

    Marian Joëls;R. Angela Sarabdjitsingh;Henk Karst

  • Corticosteroid hormones in the central stress response: quick-and-slow.

    E. Ronald de Kloet;Henk Karst;Marian Joëls

  • Chronic stress: Implications for neuronal morphology, function and neurogenesis.

    Marian Joëls;Henk Karst;Harmen J. Krugers;Paul J. Lucassen

  • Metaplasticity of amygdalar responses to the stress hormone corticosterone

    Henk Karst;Stefan Berger;Gitta Erdmann;Günther Schütz

  • Effects of chronic stress on structure and cell function in rat hippocampus and hypothalamus

    Marian Joëls;Henk Karst;Deborah Alfarez;Vivi M Heine

  • Rapid non-genomic effects of corticosteroids and their role in the central stress response

    Femke L Groeneweg;Henk Karst;E Ronald de Kloet;Marian Joëls

  • Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling.

    Femke L. Groeneweg;Henk Karst;E. Ron de Kloet;Marian Joëls

  • Corticosterone Slowly Enhances Miniature Excitatory Postsynaptic Current Amplitude in Mice CA1 Hippocampal Cells

    Henk Karst;Marian Joëls

  • Corticosteroid actions in hippocampus require DNA binding of glucocorticoid receptor homodimers.

    H. Karst;Y. J G Karten;H. M. Reichardt;E. R. De Kloet

  • Acute Activation of Hippocampal Glucocorticoid Receptors Results in Different Waves of Gene Expression Throughout Time

    M.C. Morsink;P.J. Steenbergen;J.B. Vos;H. Karst

  • Rapid changes in hippocampal CA1 pyramidal cell function via pre- as well as postsynaptic membrane mineralocorticoid receptors.

    J.E. Olijslagers;J.E. Olijslagers;E.R. de Kloet;Y. Elgersma;G.M. van Woerden

  • The stressed brain of humans and rodents

    M. Joëls;M. Joëls;H. Karst;R. A. Sarabdjitsingh

  • Corticosteroid receptor-dependent modulation of calcium currents in rat hippocampal CA1 neurons

    H. Karst;W.J. Wadman;M. Joëls

  • Glucocorticoids alter calcium conductances and calcium channel subunit expression in basolateral amygdala neurons.

    Henk Karst;Suresh Nair;Els Velzing;Lisette Rumpff-van Essen

  • Effect of Chronic Stress on Synaptic Currents in Rat Hippocampal Dentate Gyrus Neurons

    Henk Karst;Marian Joëls

  • Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior

    C. P. Fitzsimons;C. P. Fitzsimons;L. W. A. van Hooijdonk;M. Schouten;I. Zalachoras

Frequent Co-Authors

Marian Joëls
Marian Joëls University of Groningen
Wytse J. Wadman
Wytse J. Wadman University of Amsterdam
Harm J. Krugers
Harm J. Krugers University of Amsterdam
Paul J. Lucassen
Paul J. Lucassen University of Amsterdam
Onno C. Meijer
Onno C. Meijer Leiden University Medical Center
Laurent Groc
Laurent Groc University of Bordeaux
Sabine Spijker
Sabine Spijker Vrije Universiteit Amsterdam
Elly M. Hol
Elly M. Hol Utrecht University
Frank C. P. Holstege
Frank C. P. Holstege Utrecht University
Edwin Cuppen
Edwin Cuppen Utrecht University

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