World's Best Scientists 2026 revealed!

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Chemistry

D-Index
72
Citations
25515
World Ranking
5159
National Ranking
59

Biology and Biochemistry

D-Index
74
Citations
26057
World Ranking
5486
National Ranking
79

Overview

Pär Nordlund is affiliated with the Karolinska Institute in Sweden, with a research portfolio centered primarily in the fields of biochemistry, genetics, molecular biology, and medicine. Their work spans a range of subfields including molecular biology, computational theory and mathematics, public health, environmental and occupational health, oncology, and biophysics.

The scientist's research focuses on several main topics:

  • Computational Drug Discovery Methods
  • Malaria Research and Control
  • Protein Structure and Dynamics
  • Cell Image Analysis Techniques
  • RNA modifications and cancer
  • Biochemical and Molecular Research
  • Trypanosoma species research and implications

Nordlund's recent scholarly output includes publications such as:

  • "Cellular thermal shift assay for the identification of drug-target interactions in the Plasmodium falciparum proteome" (2020, Nature Protocols)
  • "CETSA interaction proteomics define specific RNA-modification pathways as key components of fluorouracil-based cancer drug cytotoxicity" (2021, Cell chemical biology)
  • "Target identification and validation of natural products with label-free methodology: A critical review from 2005 to 2020" (2020, Pharmacology & Therapeutics)
  • "New ideas for non-animal approaches to predict repeated-dose systemic toxicity: Report from an EPAA Blue Sky Workshop" (2020, Regulatory Toxicology and Pharmacology)
  • "Recent advances in proteome-wide label-free target deconvolution for bioactive small molecules" (2021, Medicinal Research Reviews)

Frequent co-authors collaborating with Nordlund include:

  • Nayana Prabhu
  • Lingyun Dai
  • Ying Liang
  • Wai Leong Tam
  • Marc-Antoine Gerault

The scientist has published multiple articles in the following venues on more than one occasion:

  • Cancer Research
  • Cell chemical biology
  • Nature Communications
  • Cell Death and Disease
  • 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)

Best Publications

  • Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

    Daniel Martinez Molina;Rozbeh Jafari;Marina Ignatushchenko;Takahiro Seki

  • The cellular thermal shift assay for evaluating drug target interactions in cells

    Rozbeh Jafari;Helena Almqvist;Hanna Axelsson;Marina Ignatushchenko

  • Crystal structure of a bacterial non-haem iron hydroxylase that catalyses the biological oxidation of methane

    Amy C. Rosenzweig;Christin A. Frederick;Stephen J. Lippard;Pär Nordlund

  • Tracking cancer drugs in living cells by thermal profiling of the proteome

    Mikhail M. Savitski;Friedrich B. M. Reinhard;Holger Franken;Thilo Werner

  • Three-dimensional structure of the free radical protein of ribonucleotide reductase

    Pär Nordlund;Britt-Marie Sjöberg;Hans Eklund

  • Thermofluor-based high-throughput stability optimization of proteins for structural studies.

    Ulrika B. Ericsson;B. Martin Hallberg;B. Martin Hallberg;George T. DeTitta;Niek Dekker

  • Protein production and purification.

    S Gräslund

  • Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination.

    Masoud Vedadi;Frank H. Niesen;Abdellah Allali-Hassani;Oleg Y. Fedorov

  • Structure and function of the Escherichia coli ribonucleotide reductase protein R2.

    Pär Nordlund;Hans Eklund

  • Ribonucleotide reductases.

    Unknown

  • Geometry of the soluble methane monooxygenase catalytic diiron center in two oxidation states

    Amy C. Rosenzweig;Pär Nordlund;Patricia M. Takahara;Christin A. Frederick

  • Understanding transport by the major facilitator superfamily (MFS): structures pave the way

    Esben M. Quistgaard;Christian Löw;Fatma Guettou;Pär Nordlund

  • Structure and function of the radical enzyme ribonucleotide reductase.

    Hans Eklund;Ulla Uhlin;Mathias Färnegårdh;Derek T. Logan

  • Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation.

    Marjolein M.G.M. Thunnissen;Pär Nordlund;Jesper Z. Haeggström

  • Crystal structure of reduced protein R2 of ribonucleotide reductase: the structural basis for oxygen activation at a dinuclear iron site.

    Derek T. Logan;Xiao Dong Su;Anders Åberg;Karin Regnström

  • The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies

    Daniel Martinez Molina;Pär Nordlund;Pär Nordlund;Pär Nordlund

  • Di-iron-carboxylate proteins.

    Pär Nordlund;Hans Eklund

  • A saposin-lipoprotein nanoparticle system for membrane proteins

    Jens Frauenfeld;Robin Löving;Jean Paul Armache;Andreas F.P. Sonnen;Andreas F.P. Sonnen

  • Green fluorescent protein as an indicator to monitor membrane protein overexpression in Escherichia coli.

    David E Drew;Gunnar von Heijne;Pär Nordlund;Jan-Willem L de Gier

  • The crystal structure of a low-molecular-weight phosphotyrosine protein phosphatase

    Xiao-Dong Su;Niccolo' Taddei;Massimo Stefani;Giampietro Ramponi

  • New insight into the structure and function of the alternative oxidase.

    Deborah A Berthold;Martin E Andersson;Pär Nordlund

Frequent Co-Authors

Hans Eklund
Hans Eklund Swedish University of Agricultural Sciences
Britt-Marie Sjöberg
Britt-Marie Sjöberg Stockholm University
Giampietro Ramponi
Giampietro Ramponi University of Florence
Amy C. Rosenzweig
Amy C. Rosenzweig Northwestern University
Peter Reichard
Peter Reichard University of Padua
Jesper Z. Haeggström
Jesper Z. Haeggström Karolinska Institute
Niccolò Taddei
Niccolò Taddei University of Florence
Massimo Stefani
Massimo Stefani University of Florence
Philipp Kaldis
Philipp Kaldis Lund University

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