World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
90
Citations
24488
World Ranking
2112
National Ranking
765

Research.com Recognitions

  • 2007 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

John D. Lipscomb is affiliated with the University of Minnesota in the United States. Their research spans primarily the fields of Chemistry and Biochemistry, Genetics and Molecular Biology, with a focus on inorganic chemistry and molecular biology as subfields.

The scientist's publications reveal a strong emphasis on metal-catalyzed oxygenation mechanisms and metal complexes synthesis and properties, alongside topics related to microbial bioremediation and biosurfactants, as well as radioactive element chemistry and processing. Their work also touches on microbial metabolism and enzyme function, atmospheric and environmental gas dynamics, and petroleum processing and analysis.

Recent papers include:

  • High-Resolution XFEL Structure of the Soluble Methane Monooxygenase Hydroxylase Complex with its Regulatory Component at Ambient Temperature in Two Oxidation States, 2020, Journal of the American Chemical Society
  • Small-Molecule Tunnels in Metalloenzymes Viewed as Extensions of the Active Site, 2021, Accounts of Chemical Research
  • Nuclear Resonance Vibrational Spectroscopic Definition of the Fe(IV)2 Intermediate Q in Methane Monooxygenase and Its Reactivity, 2021, Journal of the American Chemical Society
  • Structural Studies of the Methylosinus trichosporium OB3b Soluble Methane Monooxygenase Hydroxylase and Regulatory Component Complex Reveal a Transient Substrate Tunnel, 2020, Biochemistry
  • Soluble Methane Monooxygenase Component Interactions Monitored by 19F NMR, 2021, Biochemistry

Frequently publishing in venues such as Biochemistry and the Journal of the American Chemical Society, Lipscomb has contributed to multiple articles in these journals as well as in Accounts of Chemical Research, JBIC Journal of Biological Inorganic Chemistry, and Biopolymers.

Collaborations have often involved researchers including R. Banerjee, Melanie S. Rogers, Jason C. Jones, Kyle D. Sutherlin, and Dory E. DeWeese.

Recognition of Lipscomb's scientific contributions includes their status as a Fellow of the American Association for the Advancement of Science (AAAS), awarded in 2007.

Best Publications

  • Dioxygen activation by enzymes containing binuclear non-heme iron clusters

    Bradley J. Wallar;John D. Lipscomb

  • An Fe2IVO2 Diamond Core Structure for the Key Intermediate Q of Methane Monooxygenase

    Lijin Shu;Jeremy C. Nesheim;Karl Kauffmann;Eckard Münck

  • Versatility of biological non-heme Fe(II) centers in oxygen activation reactions

    Elena G Kovaleva;John D Lipscomb

  • Haloalkene oxidation by the soluble methane monooxygenase from Methylosinus trichosporium OB3b: Mechanistic and environmental implications

    Brian G. Fox;James G. Borneman;Lawrence P. Wackett;John D. Lipscomb

  • Biochemistry of the Soluble Methane Monooxygenase

    John D. Lipscomb

  • Methane monooxygenase from Methylosinus trichosporium OB3b. Purification and properties of a three-component system with high specific activity from a type II methanotroph.

    B. G. Fox;W. A. Froland;J. E. Dege;John D Lipscomb

  • Transient intermediates of the methane monooxygenase catalytic cycle.

    Sang Kyu Lee;Jeremy C. Nesheim;John D Lipscomb

  • Crystal structures of Fe2+ dioxygenase superoxo, alkylperoxo, and bound product intermediates.

    Elena G. Kovaleva;John D. Lipscomb

  • A Transient Intermediate of the Methane Monooxygenase Catalytic Cycle Containing an FeIVFeIV Cluster

    Sang Kyu Lee;Brian G. Fox;Wayne A. Froland;John D. Lipscomb

  • Crystal structure of the hydroxylase component of methane monooxygenase from Methylosinus trichosporium OB3b.

    Nates An Elango;Ramaswamy Radhakrishnan;Wayne A. Froland;Bradley J. Wallar

  • Structure and assembly of protocatechuate 3,4-dioxygenase

    Douglas H Ohlendorf;John D Lipscomb;P. C. Weber

  • Large kinetic isotope effects in methane oxidation catalyzed by methane monooxygenase: evidence for C-H bond cleavage in a reaction cycle intermediate.

    Jeremy C. Nesheim;John D. Lipscomb

  • Structure of the key species in the enzymatic oxidation of methane to methanol

    Rahul Banerjee;Yegor Proshlyakov;John D. Lipscomb;Denis A. Proshlyakov

  • The Roles of Putidaredoxin and P450cam in Methylene Hydroxylation

    Charles A. Tyson;John D. Lipscomb;I.C. Gunsalus

  • Finding Intermediates in the O2 Activation Pathways of Non-Heme Iron Oxygenases

    E. G. Kovaleva;M. B. Neibergall;S. Chakrabarty;John D. Lipscomb

  • Evidence for a mu-oxo-bridged binuclear iron cluster in the hydroxylase component of methane monooxygenase. Mössbauer and EPR studies.

    B G Fox;K K Surerus;E Münck;J D Lipscomb

  • Autooxidation and hydroxylation reactions of oxygenated cytochrome P-450cam.

    J. D. Lipscomb;Stephen G. Sligar;M. J. Namtvedt;I. C. Gunsalus

  • Mechanism of extradiol aromatic ring-cleaving dioxygenases

    John D Lipscomb

  • Structure of protocatechuate 3,4-dioxygenase from Pseudomonas aeruginosa at 2.15 A resolution.

    Douglas H. Ohlendorf;Allen M. Orville;John D. Lipscomb

  • OXYGEN ACTIVATION CATALYZED BY METHANE MONOOXYGENASE HYDROXYLASE COMPONENT: PROTON DELIVERY DURING THE O-O BOND CLEAVAGE STEPS

    Sang-Kyu Lee;John D. Lipscomb

Frequent Co-Authors

Eckard Münck
Eckard Münck Carnegie Mellon University
Lawrence Que
Lawrence Que University of Minnesota
Brian G. Fox
Brian G. Fox University of Wisconsin–Madison
Edward I. Solomon
Edward I. Solomon Stanford University
Douglas H. Ohlendorf
Douglas H. Ohlendorf University of Minnesota
Michael P. Hendrich
Michael P. Hendrich Carnegie Mellon University
Irwin C. Gunsalus
Irwin C. Gunsalus University of Illinois at Urbana-Champaign
Alan B. Hooper
Alan B. Hooper University of Minnesota
Stephen G. Sligar
Stephen G. Sligar University of Illinois at Urbana-Champaign
Heinz G. Floss
Heinz G. Floss University of Washington

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