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Biology and Biochemistry

D-Index
45
Citations
7846
World Ranking
19109
National Ranking
7804

Overview

Roberta Faccio is affiliated with Washington University in St. Louis in the United States. Their research spans multiple areas within medicine and biochemistry, genetics, and molecular biology, with significant contributions in molecular biology, immunology, oncology, cancer research, and hematology.

Their work involves several principal topics, including:

  • Immune cells in cancer
  • Immune Cell Function and Interaction
  • Bone health and treatments
  • Inflammasome and immune disorders
  • Autoimmune and Inflammatory Disorders Research
  • Epigenetics and DNA Methylation
  • NF-κB Signaling Pathways

Faccio has published extensively, with frequent appearances in the following venues:

  • Journal of Bone and Mineral Research
  • JBMR Plus
  • Cancer Research
  • Journal of bone oncology
  • bioRxiv (Cold Spring Harbor Laboratory)

Among their recent scientific papers are:

  • TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy, 2020, Cell
  • Multi-tissue single-cell analysis deconstructs the complex programs of mouse natural killer and type 1 innate lymphoid cells in tissues and circulation, 2021, Immunity
  • Therapy-Induced Senescence Drives Bone Loss, 2020, Cancer Research
  • The tethering function of mitofusin2 controls osteoclast differentiation by modulating the Ca2+-NFATc1 axis, 2020, Journal of Biological Chemistry
  • The microbiome restrains melanoma bone growth by promoting intestinal NK and Th1 cell homing to bone, 2022, Journal of Clinical Investigation

Their frequent co-authors include:

  • Roberto Civitelli
  • Teresita Bellido
  • Johannes Van Leeuwen
  • Kristine E. Ensrud
  • Marja M. Hurley

Best Publications

  • TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy

    Martina Molgora;Ekaterina Esaulova;William Vermi;Jinchao Hou

  • Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

    Megan K. Ruhland;Andrew J. Loza;Aude Helene Capietto;Xianmin Luo

  • Vav3 regulates osteoclast function and bone mass

    Roberta Faccio;Roberta Faccio;Steven L Teitelbaum;Keiko Fujikawa;Keiko Fujikawa;Jean Chappel

  • Oxytocin is an anabolic bone hormone

    Roberto Tamma;Graziana Colaianni;Ling Ling Zhu;Adriana DiBenedetto

  • Vav1/2/3-null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells

    Keiko Fujikawa;Ana V. Miletic;Frederick W. Alt;Frederick W. Alt;Roberta Faccio

  • The Crosstalk between the Bone and the Immune System: Osteoimmunology

    Giacomina Brunetti;Giorgio Mori;Patrizia D'Amelio;Roberta Faccio

  • c-Fms and the αvβ3 integrin collaborate during osteoclast differentiation

    Roberta Faccio;Sunao Takeshita;Alberta Zallone;F. Patrick Ross

  • PLCγ2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2

    Dailing Mao;Holly Epple;Brian Uthgenannt;Deborah V. Novack

  • Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by β3 integrin

    Roberta Faccio;Deborah V. Novack;Alberta Zallone;F. Patrick Ross

  • RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice

    Sergio Vaira;Muhammad Alhawagri;Imani Anwisye;Hideki Kitaura

  • Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance.

    Melissa A. Meyer;John M. Baer;Brett L. Knolhoff;Timothy M. Nywening

  • TREM2 and β-Catenin Regulate Bone Homeostasis by Controlling the Rate of Osteoclastogenesis

    Karel Otero;Masahiro Shinohara;Haibo Zhao;Marina Cella

  • RelB is the NF-κB subunit downstream of NIK responsible for osteoclast differentiation

    Sergio Vaira;Trevor Johnson;Angela C. Hirbe;Muhammad Alhawagri

  • The Interplay between the Bone and the Immune System

    Giorgio Mori;Patrizia D'Amelio;Roberta Faccio;Giacomina Brunetti

  • T cells support osteoclastogenesis in an in vitro model derived from human multiple myeloma bone disease: the role of the OPG/TRAIL interaction

    Silvia Colucci;Giacomina Brunetti;Giacomina Brunetti;Rita Rizzi;Rita Rizzi;Antonia Zonno;Antonia Zonno

  • A Glanzmann’s mutation in β3 integrin specifically impairs osteoclast function

    Xu Feng;Deborah V. Novack;Roberta Faccio;Daniel S. Ory

  • Cortactin has an essential and specific role in osteoclast actin assembly

    Shandiz Tehrani;Roberta Faccio;Indra Chandrasekar;F. Patrick Ross

  • The HIV protease inhibitor ritonavir blocks osteoclastogenesis and function by impairing RANKL-induced signaling

    Michael W.-H. Wang;Shi Wei;Roberta Faccio;Sunao Takeshita

  • Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCγ2 signaling axis in mice

    Daniel B. Graham;Charles M. Robertson;Jhoanne Bautista;Francesca Mascarenhas

  • Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer

    Lucia D'Amico;Sahil Mahajan;Aude Hélène Capietto;Zhengfeng Yang

Frequent Co-Authors

Steven L. Teitelbaum
Steven L. Teitelbaum Washington University in St. Louis
F. Patrick Ross
F. Patrick Ross Hospital for Special Surgery
Maria Grano
Maria Grano University of Bari Aldo Moro
Wojciech Swat
Wojciech Swat Washington University in St. Louis
Silvia Colucci
Silvia Colucci University of Luxembourg
Hiroshi Takayanagi
Hiroshi Takayanagi University of Tokyo
Gregory D. Longmore
Gregory D. Longmore Washington University in St. Louis
Vito Quaranta
Vito Quaranta Vanderbilt University
Elizabeth D. Mellins
Elizabeth D. Mellins Stanford University
Walter Reith
Walter Reith University of Geneva

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