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Chemistry

D-Index
89
Citations
35424
World Ranking
2135
National Ranking
773

Overview

Tsutomu Arakawa is affiliated with Amgen in the United States and has contributed extensively to the field of biochemistry, genetics, and molecular biology. Their work primarily focuses on molecular biology, with additional engagement in spectroscopy, materials chemistry, biomedical engineering, and radiology, nuclear medicine, and imaging.

Arakawa's research covers several key topics, including:

  • Protein purification and stability
  • Protein structure and dynamics
  • Enzyme structure and function
  • Protein interaction studies and fluorescence analysis
  • Monoclonal and polyclonal antibodies research
  • Analytical chemistry and chromatography
  • Microfluidic and capillary electrophoresis applications

They have published papers in various scientific venues, with a notable concentration in the International Journal of Biological Macromolecules and the SSRN Electronic Journal. Other frequent venues include Biophysical Chemistry, Protein Expression and Purification, and The Protein Journal.

The most recent publications by Tsutomu Arakawa include:

  • Sodium Dodecyl Sulfate Analogs as a Potential Molecular Biology Reagent, 2024, Current Issues in Molecular Biology
  • Analysis of protein denaturation, aggregation and post-translational modification by agarose native gel electrophoresis, 2021, International Journal of Biological Macromolecules
  • Agarose native gel electrophoresis for characterization of antibodies, 2020, International Journal of Biological Macromolecules
  • Structural insights into assembly and function of the RSC chromatin remodeling complex, 2020, Nature Structural & Molecular Biology
  • Western blotting analysis of proteins separated by agarose native gel electrophoresis, 2020, International Journal of Biological Macromolecules

The scientist frequently collaborates with several coauthors, including Teruo Akuta, Yui Tomioka, Masataka Nakagawa, Yasunori Kurosawa, and Chiaki Sakuma, reflecting a network of researchers engaged in related biochemical and molecular biology studies.

Best Publications

  • Stabilization of protein structure by sugars.

    Tsutomu Arakawa;Serge N. Timasheff

  • The stabilization of proteins by osmolytes.

    T. Arakawa;S.N. Timasheff

  • Dehydration-induced conformational transitions in proteins and their inhibition by stabilizers

    S.J. Prestrelski;N. Tedeschi;T. Arakawa;J.F. Carpenter

  • Preferential interactions of proteins with salts in concentrated solutions

    Tsutomu Arakawa;Serge N. Timasheff

  • Factors affecting short-term and long-term stabilities of proteins

    Tsutomu Arakawa;Steven J. Prestrelski;William C. Kenney;John F. Carpenter

  • The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis.

    Junseo Oh;Rei Takahashi;Shunya Kondo;Akira Mizoguchi

  • Mechanism of protein salting in and salting out by divalent cation salts: balance between hydration and salt binding.

    Tsutomu Arakawa;Serge N. Timasheff

  • Molecular Characterization of ALK, a Receptor Tyrosine Kinase Expressed Specifically in the Nervous System

    Toshinori Iwahara;Jiro Fujimoto;Duanzhi Wen;Rod Cupples

  • Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK.

    Chiaki Takahashi;Zeqi Sheng;Thomas P. Horan;Hitoshi Kitayama

  • Suppression of protein interactions by arginine: a proposed mechanism of the arginine effects.

    Tsutomu Arakawa;Daisuke Ejima;Kouhei Tsumoto;Noriyuki Obeyama

  • Size-Exclusion Chromatography with On-Line Light-Scattering, Absorbance, and Refractive Index Detectors for Studying Proteins and Their Interactions

    Jie Wen;Tsutomu Arakawa;John S. Philo

  • Mechanism of poly(ethylene glycol) interaction with proteins.

    Tsutomu Arakawa;Serge N. Timasheff

  • Role of Arginine in Protein Refolding, Solubilization, and Purification

    Kouhei Tsumoto;Mitsuo Umetsu;Izumi Kumagai;Daisuke Ejima

  • Practical considerations in refolding proteins from inclusion bodies

    Kouhei Tsumoto;Daisuke Ejima;Izumi Kumagai;Tsutomu Arakawa

  • Structural characterization of human erythropoietin.

    Por-Hsiung Lai;R. Everett;Fung-Fang Wang;T. Arakawa

  • Three-dimensional structures of acidic and basic fibroblast growth factors.

    X. Zhu;H. Komiya;A. Chirino;S. Faham

  • The effects of arginine on refolding of aggregated proteins: not facilitate refolding, but suppress aggregation.

    Tsutomu Arakawa;Kouhei Tsumoto

  • Theory of protein solubility.

    Tsutomu Arakawa;Serge N. Timasheff

  • Interactions of formulation excipients with proteins in solution and in the dried state.

    Unknown

  • Contribution of the surface free energy perturbation to protein-solvent interactions

    Yoshiko Kita;Tsutomu Arakawa;Tsutomu Arakawa;Tiao-Yin Lin;Serge N. Timasheff

  • Protein--solvent interactions in pharmaceutical formulations.

    Tsutomu Arakawa;Yoshiko Kita;John F. Carpenter

Frequent Co-Authors

Linda O. Narhi
Linda O. Narhi Amgen (United States)
John F. Carpenter
John F. Carpenter University of Colorado Anschutz Medical Campus
John H. Crowe
John H. Crowe University of California, Davis
Carl Nathan
Carl Nathan Cornell University
Keith Langley
Keith Langley University College London
Tadashi Yamamoto
Tadashi Yamamoto Okinawa Institute of Science and Technology
Douglas C. Rees
Douglas C. Rees California Institute of Technology
Nobuyuki Itoh
Nobuyuki Itoh Kyoto University
Akio Adachi
Akio Adachi Kansai Medical University
Eleanor N. Fish
Eleanor N. Fish University of Toronto

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