Keith Langley

Overview

Best Publications

• Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

  Krisztina M. Zsebo;David A. Williams;Edwin N. Geissler;Virginia C. Broudy

  1774
  Citations

• Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium

  Krisztina M. Zsebo;Jette Wypych;Ian K. McNiece;Hsieng S. Lu

  1186
  Citations

• Primary structure and functional expression of rat and human stem cell factor DNAs

  Francis H. Martin;Sidney V. Suggs;Keith E. Langley;Hsieng S. Lu

  1120
  Citations

• Recombinant human stem cell factor synergises with GM-CSF, G-CSF, IL-3 and epo to stimulate human progenitor cells of the myeloid and erythroid lineages.

  I. K. McNiece;K. E. Langley;K. M. Zsebo

  657
  Citations

• Inhibition of Invasion and Metastasis in Cells Transfected with an Inhibitor of Metalloproteinases

  Yves A. DeClerck;Norma Perez;Hiroyuki Shimada;Thomas C. Boone

  638
  Citations

• Induction of mast cell proliferation, maturation, and heparin synthesis by the rat c-kit ligand, stem cell factor.

  Mindy Tsai;Takashi Takeishi;Helen Thompson;Keith E. Langley

  515
  Citations

• The rat c-kit ligand, stem cell factor, induces the development of connective tissue-type and mucosal mast cells in vivo. Analysis by anatomical distribution, histochemistry, and protease phenotype.

  M. Tsai;Li-Sun Shih;G. F. J. Newlands;T. Takeishi

  409
  Citations

• TISSUE INHIBITOR OF METALLOPROTEINASE-2 (TIMP-2) BINDS TO THE CATALYTIC DOMAIN OF THE CELL SURFACE RECEPTOR, MEMBRANE TYPE 1-MATRIX METALLOPROTEINASE 1 (MT1-MMP)

  Stanley Zucker;Stanley Zucker;Michelle Drews;Cathleen Conner;Hussein D. Foda;Hussein D. Foda

  362
  Citations

• A cytokine-based neuroimmunologic mechanism of cancer-related symptoms

  Bang-Ning Lee;Robert Dantzer;Keith E. Langley;Gary J. Bennett

  360
  Citations

• The role of recombinant stem cell factor in early B cell development: Synergistic interaction with IL-7

  Ian K. McNiece;Keith E. Langley;Krisztina M. Zsebo

  294
  Citations

• Chymase cleavage of stem cell factor yields a bioactive, soluble product

  B J Longley;L Tyrrell;Y Ma;D A Williams

  279
  Citations

• cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases.

  T C Boone;M J Johnson;Y A De Clerck;K E Langley

  279
  Citations

• Purification and characterization of two related but distinct metalloproteinase inhibitors secreted by bovine aortic endothelial cells.

  Y A De Clerck;T D Yean;B J Ratzkin;H S Lu

  274
  Citations

• Molecular basis of beta-galactosidase alpha-complementation.

  Keith E. Langley;Merna R. Villarejo;Audree V. Fowler;Patrice J. Zamenhof

  267
  Citations

• The c-kit Ligand, Stem Cell Factor, Can Enhance Innate Immunity Through Effects on Mast Cells

  Marcus Maurer;Bernd Echtenacher;Lothar Hültner;George Kollias

  224
  Citations

• Inhibition of autoproteolytic activation of interstitial procollagenase by recombinant metalloproteinase inhibitor MI/TIMP-2.

  Y A DeClerck;T D Yean;H S Lu;J Ting

  214
  Citations

• Soluble stem cell factor in human serum.

  Keith E. Langley;Larry G. Bennett;Jette Wypych;Susan A. Yancik

  213
  Citations

• Clustering of Activating Mutations in c-KIT’s Juxtamembrane Coding Region in Canine Mast Cell Neoplasms

  Yongsheng Ma;B. Jack Longley;Xiaomei Wang;John L. Blount

  205
  Citations

• Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential.

  Suyun Huang;Mario Luca;Mordechai Gutman;David J. McConkey

  200
  Citations

• Direct activation of human neutrophil procollagenase by recombinant stromelysin

  V Knäuper;S M Wilhelm;P K Seperack;Y A DeClerck

  196
  Citations