World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
71
Citations
15235
World Ranking
6767
National Ranking
3135

Overview

Chen Yan is affiliated with the University of Rochester in the United States and has an extensive research profile primarily within the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans a variety of subfields including Molecular Biology, Pulmonary and Respiratory Medicine, Cardiology and Cardiovascular Medicine, Epidemiology, and Immunology.

The scientist's research topics cover significant ground with emphasis on areas such as Phosphodiesterase function and regulation, Hematopoietic Stem Cell Transplantation, Acute Myeloid Leukemia Research, Epigenetics and DNA Methylation, Mitochondrial Function and Pathology, RNA modifications and cancer, as well as Inflammasome and immune disorders.

Chen Yan has contributed to multiple papers, notable among which are:

  • SPIRou: NIR velocimetry and spectropolarimetry at the CFHT (2020), published in Monthly Notices of the Royal Astronomical Society
  • Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice (2020), published in PLoS Biology
  • The lipid peroxidation product 4-hydroxynonenal inhibits NLRP3 inflammasome activation and macrophage pyroptosis (2022), published in Cell Death and Differentiation
  • Dihydroquercetin suppresses cigarette smoke induced ferroptosis in the pathogenesis of chronic obstructive pulmonary disease by activating Nrf2-mediated pathway (2021), published in Phytomedicine
  • Exosome-mediated pyroptosis of miR-93-TXNIP-NLRP3 leads to functional difference between M1 and M2 macrophages in sepsis-induced acute kidney injury (2021), published in Journal of Cellular and Molecular Medicine

The scientist frequently collaborates with several researchers, including Si Chen, Lan-Ping Xu, Xiao-Jun Huang, Xiao-Dong Mo, and Hangchuan Shi.

Chen Yan's work has appeared often in various publication venues, with a significant number of papers published in:

  • PubMed
  • Circulation
  • bioRxiv (Cold Spring Harbor Laboratory)
  • SSRN Electronic Journal
  • Circulation Research

Best Publications

  • Cyclic GMP Phosphodiesterases and Regulation of Smooth Muscle Function

    Sergei D. Rybalkin;Chen Yan;Karin E. Bornfeldt;Joseph A. Beavo

  • Double-layer nanoparticle-based coatings for efficient terrestrial radiative cooling

    Hua Bao;Chen Yan;Boxiang Wang;Xing Fang

  • Cyclophilin A Is a Secreted Growth Factor Induced by Oxidative Stress

    Zheng-Gen Jin;Matthew G. Melaragno;Duan-Fang Liao;Chen Yan

  • Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms.

    Kimio Satoh;Patrizia Nigro;Tetsuya Matoba;Michael R. O'Dell

  • Fluid shear stress inhibits TNF-α activation of JNK but not ERK1/2 or p38 in human umbilical vein endothelial cells: Inhibitory crosstalk among MAPK family members

    James Surapisitchat;Ryan J. Hoefen;Xinchun Pi;Masanori Yoshizumi

  • Endothelial Atheroprotective and Anti-inflammatory Mechanisms

    Bradford C. Berk;Jun Ichi Abe;Wang Min;James Surapisitchat

  • Vinpocetine inhibits NF-κB–dependent inflammation via an IKK-dependent but PDE-independent mechanism

    Kye Im Jeon;Xiangbin Xu;Toru Aizawa;Jae Hyang Lim

  • Upregulation of Phosphodiesterase 1A1 Expression Is Associated With the Development of Nitrate Tolerance

    Dongsoo Kim;Sergei D. Rybalkin;Xinchun Pi;Yining Wang

  • Differential Regulation of Mitogen-Activated Protein Kinases ERK1/2 and ERK5 by Neurotrophins, Neuronal Activity, and cAMP in Neurons

    Jane E. Cavanaugh;James Ham;Michal Hetman;Steve Poser

  • Fluid shear stress stimulates big mitogen-activated protein kinase 1 (BMK1) activity in endothelial cells. Dependence on tyrosine kinases and intracellular calcium

    Chen Yan;Masafumi Takahashi;Masanori Okuda;Jiing-Dwan Lee

  • Insulin-Like Growth Factor-1 Enhances Inflammatory Responses in Endothelial Cells: Role of Gab1 and MEKK3 in TNF-α–Induced c-Jun and NF-κB Activation and Adhesion Molecule Expression

    Wenyi Che;Nicole Lerner-Marmarosh;Qunhua Huang;Masaki Osawa

  • Cyclophilin A Mediates Vascular Remodeling by Promoting Inflammation and Vascular Smooth Muscle Cell Proliferation

    Kimio Satoh;Tetsuya Matoba;Jun Suzuki;Michael R. O'Dell

  • Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons

    Chen Yan;A. Z. Zhao;J. K. Bentley;K. Loughney

  • Functional interplay between angiotensin II and nitric oxide: cyclic GMP as a key mediator.

    Chen Yan;Dong Soo Kim;Toru Aizawa;Bradford C. Berk

  • The Calmodulin-dependent Phosphodiesterase Gene PDE1C Encodes Several Functionally Different Splice Variants in a Tissue-specific Manner

    Chen Yan;Allan Z. Zhao;J. Kelley Bentley;Joseph A. Beavo

  • Functional Role of Phosphodiesterase 3 in Cardiomyocyte Apoptosis Implication in Heart Failure

    Bo Ding;Jun Ichi Abe;Heng Wei;Qunhua Huang

  • Distinct positive and negative elements control the limited hepatocyte and choroid plexus expression of transthyretin in transgenic mice.

    Chen Yan;R. H. Costa;J. E. Darnell;Jiandong Chen

  • Big Mitogen-Activated Protein Kinase (BMK1)/ERK5 Protects Endothelial Cells From Apoptosis

    Xinchun Pi;Chen Yan;Bradford C. Berk

  • Opposing Effects of Reactive Oxygen Species and Cholesterol on Endothelial Nitric Oxide Synthase and Endothelial Cell Caveolae

    Timothy E. Peterson;Veronica Poppa;Hiroto Ueba;Albert Wu

  • Smooth muscle cell plasticity: fact or fiction?

    Anh T. Nguyen;Delphine Gomez;Robert D. Bell;Julie H. Campbell

Frequent Co-Authors

Bradford C. Berk
Bradford C. Berk University of Rochester
Jun Ichi Abe
Jun Ichi Abe The University of Texas MD Anderson Cancer Center
Jian-Dong Li
Jian-Dong Li Georgia State University
Wenyuan Xu
Wenyuan Xu Zhejiang University
Joseph A. Beavo
Joseph A. Beavo University of Washington
Carlos A. Molina
Carlos A. Molina Montclair State University
Xin-Hua Feng
Xin-Hua Feng Zhejiang University
Kevin Fu
Kevin Fu University of Michigan–Ann Arbor
Keigi Fujiwara
Keigi Fujiwara The University of Texas MD Anderson Cancer Center
Paul S. Brookes
Paul S. Brookes University of Rochester Medical Center

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